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公开(公告)号：US12098403B2
公开(公告)日：2024-09-24
申请号：US17061741
申请日：2020-10-02
申请人： Inbiose N.V.
发明人： Jo Maertens , Joeri Beauprez , Marjan De Mey
IPC分类号： C12P19/14 , C12N9/10 , C12N9/26 , C12N9/90 , C12N15/52 , C12N15/70 , C12N15/81 , C12P19/18 , C12P19/30
CPC分类号： C12P19/14 , C12N9/1051 , C12N9/2431 , C12N9/90 , C12N15/52 , C12N15/70 , C12N15/81 , C12P19/18 , C12P19/305 , C12Y204/01007 , C12Y204/01008 , C12Y204/01022 , C12Y204/01069 , C12Y302/01026 , C12Y504/02002
摘要： The present invention relates to genetically engineered organisms, especially microorganisms such as bacteria and yeasts, for the production of added value bio-products such as specialty saccharide, activated saccharide, nucleoside, glycoside, glycolipid or glycoprotein. More specifically, the present invention relates to host cells that are metabolically engineered so that they can produce said valuable specialty products in large quantities and at a high rate by bypassing classical technical problems that occur in biocatalytical or fermentative production processes.
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2.发明公开公开(公告)号：US20240309416A1
公开(公告)日：2024-09-19
申请号：US18576640
申请日：2022-10-12
发明人： Yan WU , Jing TANG , Shu WANG , Zhenhua TIAN , Fei YAO , Miao LI , Hong XU , Chenxi HUANG , Yurou LIU
IPC分类号： C12P19/26 , C12N1/20 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/90 , C12N15/70 , C12P19/18 , C12R1/19
CPC分类号： C12P19/26 , C12N1/205 , C12N9/1029 , C12N9/1081 , C12N9/1085 , C12N9/1096 , C12N9/1241 , C12N9/1294 , C12N9/16 , C12N9/90 , C12N15/70 , C12P19/18 , C12R2001/19 , C12Y203/01004 , C12Y204/99001 , C12Y204/99004 , C12Y205/01056 , C12Y206/01016 , C12Y207/07043 , C12Y207/09002 , C12Y301/03 , C12Y501/03014
摘要： The invention discloses a genetically engineered bacterium and its application in the preparation of sialyllactose. The genetically engineered bacterium has an N-acetylneuraminic acid biosynthesis pathway, includes multiple copies of a gene neuB for encoding sialic acid synthase, and the gene neuB is initiated for expression by a strong promoter. Using the genetically engineered bacteria of the invention to produce sialyllactose has the advantages of high yield and low overall cost.
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公开(公告)号：US12071614B2
公开(公告)日：2024-08-27
申请号：US17049855
申请日：2018-04-23
申请人： INBIOSE N.V.
摘要： A fermentation broth which includes a microbial cell which has been subjected to a condition under which the activity an endogenous transporter for 2′ fucosyllactose is increased. Also provided are methods for increasing export of 2′ fucosyllactose from a microbial cell, methods for identifying an endogenous yeast transporter of 2′ fucosyllactose, and microbial cells genetically engineered to increase the activity of an endogenous transporter of 2′ fucosyllactose.
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公开(公告)号：US20240200112A1
公开(公告)日：2024-06-20
申请号：US18393339
申请日：2023-12-21
申请人： Chr. Hansen HMO GmbH
IPC分类号： C12P19/18 , C07K14/24 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/88 , C12N9/90 , C12N15/52 , C12N15/70
CPC分类号： C12P19/18 , C07K14/24 , C12N9/0006 , C12N9/1051 , C12N9/12 , C12N9/1205 , C12N9/1241 , C12N9/16 , C12N9/88 , C12N9/90 , C12N15/52 , C12N15/70 , C12Y101/01271 , C12Y204/01065 , C12Y207/01011 , C12Y207/07013 , C12Y301/03011 , C12Y401/02013 , C12Y402/01047 , C12Y504/02008
摘要： The present invention relates to a method for producing fucosylated oligosaccharides by using a recombinant prokaryotic host cell that is cultivated on a gluconeogenic substrate, as well as to the host cell and its use. The host cell is genetically modified in that the activity of a fructose-6-phosphate converting enzyme is abolished or lowered, and the transport of the produced fucosylated oligosaccharide through the cell membrane is facilitated by an exogenous transport protein.
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公开(公告)号：US20240174987A1
公开(公告)日：2024-05-30
申请号：US18525234
申请日：2023-11-30
申请人： AMYRIS, INC.
发明人： Lishan ZHAO , Wenzong LI , Gale WICHMANN , Aditi KHANKHOJE , Chantal GARCIA DE GONZALO , Tina MAHATDEJKUL-MEADOWS , Shaina JACKSON , Michael LEAVELL , Darren PLATT
CPC分类号： C12N9/1051 , A23L2/60 , A23L27/36 , C12N15/52 , C12N15/81 , C12P19/18 , C12P19/56 , C12Y204/01017 , A23V2002/00
摘要： Provided herein are compositions and methods for improved production of steviol glycosides in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding a Setaria italica UDP-glycosyltransferase 40087 or its variant UDP-glycosyltransferase. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding a UDP-glycosyltransferase sr.UGT_9252778, Bd_UGT10850, and/or Ob_UGT91B1_like. In some embodiments, the host cell further comprises one or more heterologous nucleotide sequence encoding further enzymes of a pathway capable of producing steviol glycosides in the host cell. The compositions and methods described herein provide an efficient route for the heterologous production of steviol glycosides, including but not limited to, rebaudioside D and rebaudioside M.
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公开(公告)号：US11987694B2
公开(公告)日：2024-05-21
申请号：US17187968
申请日：2021-03-01
CPC分类号： C08L5/00 , C08B37/0009 , C12P19/04 , C12P19/18
摘要： Disclosed herein are compositions comprising polysaccharide particles with an average size of about 0.1-10 mm. These particles comprise at least (i) about 50%-90% by weight water or an aqueous solution, and (ii) about 10%-50% by weight insoluble alpha-glucan, or an insoluble cationic ether thereof, comprising alpha-1,3-glycosidic linkages and having a weight-average degree of polymerization (DPw) of at least about 100. Further disclosed are methods of preparing these compositions, as well as systems for storing and/or moving them.
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公开(公告)号：US20240124909A1
公开(公告)日：2024-04-18
申请号：US18277380
申请日：2022-02-28
发明人： Seon Won KIM , Seong Hee JEONG , Ji Bin PARK , Moon Hyuk KWON
CPC分类号： C12P19/18 , C12N9/1051 , C12P19/02 , C12Y204/01007
摘要： Provided is a composition and a fructose production method, wherein the composition contains: sucrose phosphorylase or a microorganism expressing same; or a culture or lysate of the microorganism whereby fructose can be produced at low cost with high yield.
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公开(公告)号：US11957144B2
公开(公告)日：2024-04-16
申请号：US16995434
申请日：2020-08-17
申请人： PureCircle Sdn Bhd
CPC分类号： A23L27/33 , A23L2/60 , A23L27/36 , A23L27/88 , A23V2002/00 , A23V2200/16 , A23V2250/258 , A23V2250/5114 , A23V2002/00 , A23V2200/16 , A23V2250/258 , A23V2250/5114
摘要： A taste and flavor profile modifying composition is described. The composition includes a blend of glucosylated steviol glycosides and residual steviol glycosides which can modify the intensity of a taste and/or flavor in a food or beverage product.
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公开(公告)号：US20240060056A1
公开(公告)日：2024-02-22
申请号：US18267928
申请日：2021-12-16
申请人： Amyris, Inc.
CPC分类号： C12N9/1051 , C12P19/18 , C12N1/165 , C12Y204/01146 , C12R2001/85
摘要： Provided herein are variant β-1,3-N-acetylglucosaminyltransferase polypeptides capable of producing lacto-n-neotetraose, yeast cells capable of producing one or more human milk oligosaccharides, and methods of making such cells. Also, provided are fermentation compositions including the disclosed genetically modified yeast cells, and related methods of producing and recovering HMOs generated by the yeast cells.
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公开(公告)号：US20240043891A1
公开(公告)日：2024-02-08
申请号：US18258770
申请日：2021-12-21
申请人： GLYCOM A/S
发明人： Margit PEDERSEN
CPC分类号： C12P19/18 , C12N9/1051 , C12Y204/01069 , C12Y204/01065
摘要： The present invention relates to a genetically modified cell expressing an α-1,2-fucosyltransferase and an α-1,3-fucosyltransferase, and a transporter protein of the major facilitator superfamily (MFS) and to a method for recombinant production of human milk oligosaccharides (HMOs) using said genetically modified cell. More particularly, the invention provides a method for recombinant production of and a genetically modified cell capable of producing difucosyllactose (DFL) as the most abundant HMO, with a relatively low content of 3-fucosyllactose (3FL) and/or 2′-fucosyllactose (2′FL).
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