-
公开(公告)号:US11442072B2
公开(公告)日:2022-09-13
申请号:US16459524
申请日:2019-07-01
发明人: Katariina Öörni , Maija Ruuth , Petri Kovanen
摘要: The present disclosure relates to a method for measuring aggregation of low-density lipoprotein (LDL). The susceptibility of LDL to aggregate is an important factor regarding prognosis, diagnosis and surveillance of atherosclerotic cardiovascular diseases and cardiometabolic diseases, such as type 2 diabetes and related conditions, at various stages of their development. Also provided are methods of treatment of such diseases in subjects in need thereof.
-
公开(公告)号:US20210003562A1
公开(公告)日:2021-01-07
申请号:US17023946
申请日:2020-09-17
申请人: SYSMEX CORPORATION
发明人: Keiko YOSHIKAWA , Amane HARADA , Katsuhiro MURAKAMI , Maria KIRIYAMA , Keiko MIWA , Takuya KUBO
摘要: The present invention relates to a method for measuring the cholesterol uptake capacity of lipoproteins. The present invention also relates to a reagent kit for measuring the cholesterol uptake capacity of lipoproteins. The present invention further relates to a tagged cholesterol which can be used in the method and the reagent kit.
-
公开(公告)号:US10293043B2
公开(公告)日:2019-05-21
申请号:US15313465
申请日:2015-05-06
发明人: John Brian Mumm , Ivan Ho Chan
IPC分类号: C12Q1/60 , C07K14/47 , A61K38/00 , A61K38/17 , A61K38/20 , G01N33/50 , A61K39/385 , A61K49/00 , C07K14/715 , C07K17/02 , A61K47/60 , G01N33/92 , A61K48/00
摘要: Methods of treating subjects having diseases, disorders, or conditions, including disorders associated with cholesterol homeostasis, responsive to agents modulating Kupffer cell function, including methods of administration and dosing regimens associated therewith, are provided. Methods of treating subjects having liver diseases, disorders, or conditions, including non-alcoholic steatohepatitis and non-alcoholic fatty liver disease, with an IL-10 agent are also provided.
-
公开(公告)号:US10156579B2
公开(公告)日:2018-12-18
申请号:US15054510
申请日:2016-02-26
发明人: Ian Gibbons , Shaunak Roy , Edmond Ku
摘要: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
-
公开(公告)号:US09989542B2
公开(公告)日:2018-06-05
申请号:US14952015
申请日:2015-11-25
IPC分类号: G01N33/92 , G01N33/48 , G01N33/52 , G01N33/80 , G01N33/96 , G01N21/78 , G01N27/27 , G01N27/416 , C12Q1/60 , G01N33/49 , G01N21/84 , G01N27/327
CPC分类号: G01N33/92 , C12Q1/60 , G01N21/78 , G01N21/8483 , G01N27/27 , G01N27/3274 , G01N33/492 , G01N33/52 , G01N33/80 , G01N33/96
摘要: A system for determining a level of a lipid analyte corrected for hematocrit includes a test strip configured to receive a sample and a meter configured to receive the test strip. The system further includes circuitry and a microprocessor, the circuitry and microprocessor configured to read the test strip and the sample and determine a level of a lipid analyte and correct the level of the lipid analyte based on a hematocrit level of the sample.
-
公开(公告)号:US09890412B2
公开(公告)日:2018-02-13
申请号:US14391897
申请日:2013-04-10
发明人: Yasuki Itoh , Hitoshi Chiba
CPC分类号: C12Q1/60 , G01N33/92 , G01N2333/775
摘要: Provided is a method for separately or simultaneously quantifying whole HDL-C and cholesterol in HDL subfractions: ApoE-Containing HDL-C and ApoE-deficient HDL-C. A method for enzymatically and separately quantifying cholesterol in the ApoE-deficient HDL comprising: adding a surfactant composed of a polyoxyethylene benzyl phenyl ether derivative to a test sample in a final concentration of 0.05 to 0.10%, reacting the test sample with cholesterol esterase and cholesterol oxidase, and quantifying hydrogen peroxide generated. A method for enzymatically and separately quantifying cholesterol in ApoE-Containing HDL comprising: adding a surfactant composed of a polyoxyethylene benzyl phenyl ether derivative so as to obtain a final concentration of 0.15 to 0.75%, reacting the test sample with cholesterol esterase and cholesterol oxidase, and quantifying hydrogen peroxide generated.
-
公开(公告)号:US20170349933A1
公开(公告)日:2017-12-07
申请号:US15629672
申请日:2017-06-21
申请人: AXIS-SHIELD AS
摘要: The invention provides an enzymatic method for measuring the concentration of one or more analytes in the plasma portion of a blood derived sample, containing a first and a second component, where said second component interferes with the measurement of said first component. The method includes: i) diluting the sample with a reagent mixture; ii) substantially removing blood cells; iii) using a reagent which serves to temporarily prevent reaction of the second component, to generate a blocked second component; iv) causing the selective reaction of a constituent of each analyte to directly or indirectly generate detectable reaction products, where one of the analytes is the first component; v) monitoring the detectable reaction product or products; vi) relating an amount of the detectable product or products and/or a rate of formation of the detectable product or products to the concentration of each analyte, where the concentration of at least the first component is related to a corresponding detectable reaction product by means of estimating an un-measurable (fictive) endpoint. Step iii) may be carried out at any stage up to and including step iv) but before steps v) or vi). The reagent of step iii) may be applied to the sample separately or may be included in a reagent mixture during steps i) or iv). A corresponding kit is also provided.
-
公开(公告)号:US20170281650A1
公开(公告)日:2017-10-05
申请号:US15508278
申请日:2014-09-02
申请人: Lei Guan , Youyou Zhao , Junkuan Wang , NESTEC S.A.
发明人: Lei Guan , Youyou Zhao , Junkuan Wang
IPC分类号: A61K31/575 , A61K9/00 , C12Q1/60
CPC分类号: A61K31/575 , A61K9/0053 , C12Q1/60
摘要: The use of dihydrocholesterol (DHC) in low doses of up to 50 mg per kg of body weight to treat or prevention excess weight or obesity and/or hyperlipidemia, and/or a disorders associated with any of the foregoing, and a composition comprising DHC.
-
9.
公开(公告)号:US20170211125A1
公开(公告)日:2017-07-27
申请号:US15481782
申请日:2017-04-07
申请人: Pop Test LLC
CPC分类号: C12Q1/52 , C12Q1/54 , C12Q1/60 , C12Q1/62 , C12Y206/01001 , C12Y206/01002 , G01N21/29 , G01N21/78 , G01N33/52 , G01N33/523 , G01N33/558 , G01N33/57438 , G01N33/66 , G01N33/92 , G01N33/98 , G01N2021/752 , G01N2333/91188 , G01N2800/085
摘要: A device is disclosed for conducting a non-invasive analysis of a bodily fluid to determine the presence and level of a certain constituent carried by the bodily fluid. An indicator formulation of the device changes color in response to exposure to the constituent to provide a visible indication of the presence and level of the constituent carried by the bodily fluid. A carrier substrate of the device is constructed of a material having voids providing a high void volume within the substrate. The device is made by applying a chromagen to the carrier substrate to create a chromagen-laden carrier member. Then, a selected reagent having a particular constituent-specific formulation is applied to the chromagen-laden member. The selected reagent then combines with the chromagen thereby establishing the indicator formulation within the carrier substrate in place for reception of a sample of the bodily fluid.
-
公开(公告)号:US09470698B2
公开(公告)日:2016-10-18
申请号:US14961634
申请日:2015-12-07
CPC分类号: G01N33/92 , C12Q1/60 , G01N21/78 , G01N33/48 , G01N33/525 , G01N2021/7759 , G01N2021/7773
摘要: In one embodiment, a test strip for testing for cholesterol-related blood analytes in whole blood includes a red blood cell separation layer, the red blood cell separation layer separating red blood cells from a blood sample applied to the test strip as the blood sample flows downward through the red blood cell separation layer. The test strip further includes a reaction layer receiving the blood sample from the red blood cell separation layer, the reaction layer including POE-POP-POE block copolymer, a surfactant, and a reflectivity changing reactant, the POE-POP-POE block copolymers solubilizing essentially only non-LDL cholesterol analytes, the non-LDL cholesterol analytes reacting with the reflectivity changing reactant in order to change a reflectivity of the blood sample.
-
-
-
-
-
-
-
-
-