公开(公告)号：US20240360593A1

公开(公告)日：2024-10-31

申请号：US18292885

申请日：2022-11-15

申请人： SÜLEYMAN DEMIREL ÜNIVERSITESI IDARI VE MALI ISLER DAIRE BASKANLIGI GENELSEKRETERLIK

发明人： Funda CENGIZ ÇALLIOGLU ,  Hülya KESICI GÜLER

IPC分类号： D01F6/56 ,  A61K9/70 ,  A61K31/7052 ,  A61K47/42 ,  D01D5/00 ,  D06M13/372 ,  D06M23/10 ,  D06M101/18

CPC分类号： D01F6/56 ,  A61K9/7084 ,  A61K31/7052 ,  A61K47/42 ,  D01D5/0007 ,  D06M13/372 ,  D06M23/10 ,  D06M2101/18 ,  D06M2200/00 ,  D10B2211/20 ,  D10B2321/12 ,  D10B2509/00

摘要： Disclosed herein is the production of medical textile material with nanofiber surface that has transdermal drug release properties and that is coated with azithromycin active substance by using needle electrospinning method and ultrasonic spray pyrolysis (USP) technique. Specifically disclosed is a nanofiber medical textile material production method that includes the steps of preparing polymer solutions containing PVP (polyvinylpyrrolidone) with a concentration of 12 wt % and GEL (gelatin) with a concentration of 0.72 wt %; determining solution properties such as conductivity, viscosity, and surface tension, producing nanofibers from prepared polymer solutions by atmosphere-controlled horizontal needle fiber spinning (electrospinning) setup, obtaining PVP/GEL nanofibers after the fiber spinning process, thin film coating of the drug active substance on the obtained nanofibers, PVP/GEL nanofibers by the USP method, and cross-linking of both polymers to facilitate the final application processes of the drug-release material.

公开(公告)号：US12128080B2

公开(公告)日：2024-10-29

申请号：US17254373

申请日：2019-06-17

申请人： NSC PHARMA GMBH & CO. KG

发明人： Rolf Daniels ,  Francis Karnau Mwiiri

IPC分类号： A61K36/185 ,  A61K9/107 ,  A61K9/12 ,  A61K9/70 ,  A61K31/015 ,  A61K31/047 ,  A61K31/19 ,  A61K31/215 ,  A61K47/24 ,  A61K47/32 ,  A61K47/44 ,  A61P17/02 ,  D01D5/00 ,  D04H1/728

CPC分类号： A61K36/185 ,  A61K9/1075 ,  A61K9/122 ,  A61K9/7015 ,  A61K31/015 ,  A61K31/047 ,  A61K31/19 ,  A61K31/215 ,  A61K47/24 ,  A61K47/32 ,  A61K47/44 ,  A61P17/02 ,  D01D5/0007 ,  D04H1/728 ,  D10B2509/022

摘要： The present invention relates to compositions based on nanodispersions which are preferably further processed to electrospun fibers comprising such nanodispersions. The nanodispersions may optionally contain birch bark extract. The electrospun fibers can be used in particular for the treatment of wounds. For this purpose the compositions containing electrospun fibers are preferably applied as such or in a spray or a foam.

公开(公告)号：US12115275B2

公开(公告)日：2024-10-15

申请号：US17179971

申请日：2021-02-19

申请人： Boston Scientific Scimed, Inc.

发明人： Joseph Thomas Delaney, Jr. ,  Patrick Willoughby ,  David Robert Wulfman ,  Andrew J. Ro ,  Niraj Gurung

IPC分类号： A61L27/16 ,  A61L27/48 ,  C08J3/24 ,  C08L53/00 ,  D01D5/00 ,  D01D5/098

CPC分类号： A61L27/16 ,  A61L27/48 ,  C08J3/246 ,  C08L53/00 ,  D01D5/0023 ,  D01D5/003 ,  D01D5/0985 ,  A61L2430/20 ,  C08J2323/18 ,  C08J2323/22 ,  C08J2337/00 ,  C08J2479/02 ,  C08L2203/02 ,  D10B2509/06 ,  A61L27/48 ,  C08L23/22

摘要： Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.

公开(公告)号：US12109730B2

公开(公告)日：2024-10-08

申请号：US17591447

申请日：2022-02-02

申请人： Aladdin Manufacturing Corporation

发明人： Thomas R. Clark

IPC分类号： B29B7/46 ,  B01D29/00 ,  B29B7/72 ,  B29B9/06 ,  B29B17/00 ,  B29B17/02 ,  B29C48/00 ,  B29C48/05 ,  B29C48/14 ,  B29C48/255 ,  B29C48/38 ,  B29C48/385 ,  B29C48/425 ,  B29C48/43 ,  B29C48/44 ,  B29C48/70 ,  B29C48/76 ,  B29C48/80 ,  B29C48/88 ,  B29C48/92 ,  B29C69/00 ,  B29D99/00 ,  C08J11/04 ,  C08J11/06 ,  D01D1/10 ,  D01D5/00 ,  D01D5/08 ,  D01F6/62 ,  B29B13/00 ,  B29C48/435 ,  B29K67/00 ,  B29K105/00 ,  B29K105/26

CPC分类号： B29B17/02 ,  B01D29/0095 ,  B29B7/726 ,  B29B9/065 ,  B29B17/00 ,  B29C48/0022 ,  B29C48/05 ,  B29C48/145 ,  B29C48/255 ,  B29C48/2552 ,  B29C48/38 ,  B29C48/385 ,  B29C48/425 ,  B29C48/43 ,  B29C48/44 ,  B29C48/70 ,  B29C48/765 ,  B29C48/767 ,  B29C48/802 ,  B29C48/92 ,  B29C69/001 ,  B29D99/0078 ,  C08J11/04 ,  C08J11/06 ,  D01D1/103 ,  D01D1/106 ,  D01D5/00 ,  D01D5/08 ,  D01F6/62 ,  B29B2013/002 ,  B29B2013/005 ,  B29B2017/0015 ,  B29B2017/0224 ,  B29C48/144 ,  B29C48/435 ,  B29C48/766 ,  B29C2791/006 ,  B29C2793/00 ,  B29C2948/922 ,  B29C2948/9238 ,  B29C2948/92514 ,  B29C2948/92876 ,  B29K2067/003 ,  B29K2105/0067 ,  B29K2105/26 ,  C08J2367/02 ,  D10B2503/04 ,  Y02P20/143 ,  Y02W30/62

摘要： A method for manufacturing pellets from polymer, comprising: (1) melting polymer flakes in a first section of a melt processing unit to create a first single stream of polymer melt; (2) separating the first single stream of polymer melt into multiple streams of polymer melt by means of a separation element; (3) passing the multiple streams through a multiple stream section of said melt processing unit and exposing the multiple streams to a pressure within the multiple stream section of the melt processing unit as the multiple streams pass through the multiple stream section; (4) recombining the multiple streams into at least one combined stream of polymer melt; and (5) cooling the polymer melt and forming said pellets from the at least one combined stream. The intrinsic viscosity of the at least one combined stream may be determined and, in response, the chamber pressure within the multiple stream section adjusted.

公开(公告)号：US12109317B2

公开(公告)日：2024-10-08

申请号：US17564096

申请日：2021-12-28

申请人： NATIONAL CHENG KUNG UNIVERSITY

发明人： Ping-Ching Wu ,  Cheng-Hsin Chuang ,  Po-Heng Chen ,  Yu-Yi Chiang

IPC分类号： A61K9/70 ,  A61K9/16 ,  A61K31/573 ,  A61K35/15 ,  A61K35/33 ,  A61K47/32 ,  A61K47/34 ,  A61L15/26 ,  A61L15/44 ,  A61L27/38 ,  A61L27/56 ,  C08L29/04 ,  C08L67/04 ,  D01D5/00 ,  D01F1/10 ,  A61P17/02

CPC分类号： A61K9/70 ,  A61K31/573 ,  A61K35/15 ,  A61K35/33 ,  A61K47/32 ,  A61K47/34 ,  A61L15/26 ,  A61L15/44 ,  C08L29/04 ,  C08L67/04 ,  D01D5/0015 ,  D01F1/10 ,  A61P17/02 ,  C08L2203/02 ,  C08L2203/12

摘要： Disclosed herein are electrospun fibrous matrix and its production method. The method mainly includes the steps of, mixing a first polymer and a drug to form a first mixture, and sonicating the first mixture until a plurality of microparticles are formed with the drug encapsulated therein; and mixing the plurality of microparticles with a second polymer to form a second mixture, subjecting the second mixture to a wet electrospinning process to form the electrospun fibrous matrix. The thus-produced electrospun fibrous matrix is characterized by having a plurality of first and second fibrils woven together, in which each second fibril has a plurality of drug-encapsulated microparticles independently integrated and disposed along the longitudinal direction of the second fibril. Also disclosed herein is a method for treating a wound of a subject. The method includes applying the present electrospun fibrous matrix to the wound of the subject.

公开(公告)号：US12091778B2

公开(公告)日：2024-09-17

申请号：US17629644

申请日：2020-07-24

申请人： NANOSHIELDS TECHNOLOGY LIMITED

发明人： Siu Wah Wong

IPC分类号： D01D5/00 ,  D04H1/4382 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： D01D5/0084 ,  D01D5/003 ,  D01D5/0069 ,  D04H1/43838 ,  B82Y30/00 ,  B82Y40/00

摘要： It provides a device for applying nanofibers and/or microfibers onto a substrate (S). It also provides a system comprising a plurality of such devices which are controlled to operate independently. The system allows for depositing of a gradient material in various parameters including material thickness, fiber pore size, fiber diameter, fiber content and the like. It also relates to a method for applying nanofibers and/or microfibers onto a substrate (S).

公开(公告)号：US20240304779A1

公开(公告)日：2024-09-12

申请号：US18567888

申请日：2021-12-06

申请人： VANDERBILT UNIVERSITY

发明人： Peter N. Pintauro ,  Ryszard Wycisk

IPC分类号： H01M4/04 ,  B05B5/025 ,  D01D1/02 ,  D01D5/00 ,  D01F1/09 ,  D01F6/12 ,  D01F6/16 ,  D01F6/18 ,  D01F6/60 ,  D04H1/4282 ,  D04H1/43 ,  D04H1/4318 ,  D04H1/4334 ,  D04H1/728 ,  H01M4/02 ,  H01M4/134 ,  H01M4/1395 ,  H01M4/38 ,  H01M4/62 ,  H01M10/0525

CPC分类号： H01M4/0404 ,  B05B5/0255 ,  D01D1/02 ,  D01D5/0038 ,  D01D5/0076 ,  D01F1/09 ,  D01F6/12 ,  D01F6/16 ,  D01F6/18 ,  D01F6/60 ,  D04H1/4282 ,  D04H1/43 ,  D04H1/4318 ,  D04H1/4334 ,  D04H1/728 ,  H01M4/0419 ,  H01M4/134 ,  H01M4/1395 ,  H01M4/386 ,  H01M4/622 ,  D10B2321/042 ,  D10B2321/08 ,  D10B2321/10 ,  D10B2331/02 ,  D10B2505/00 ,  H01M2004/027 ,  H01M10/0525

摘要： An ink and electrodes fabricated with the ink. The ink includes a dispersion of fibers in at least one solvent. Said fibers have one or more fiber types, where at least one type of said fibers comprises at least one catalyst for an electrochemical reaction and at least one binder polymer.

公开(公告)号：US12087911B2

公开(公告)日：2024-09-10

申请号：US17594650

申请日：2020-04-23

申请人： THE JAPAN STEEL WORKS, LTD. ,  NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY

发明人： Ryo Ishiguro ,  Satoru Nakamura ,  Midori Takasaki ,  Sotaro Nambu

IPC分类号： B29C48/36 ,  D01D5/00 ,  D01D10/02 ,  D04H3/007 ,  H01M6/18 ,  H01M10/0562 ,  H01M10/0585 ,  H01M50/403 ,  H01M50/406 ,  B29D99/00 ,  B29K23/00 ,  B29K401/00 ,  B29L31/00

CPC分类号： H01M10/0585 ,  D01D5/0023 ,  D01D5/0038 ,  D01D5/0061 ,  D01D5/0084 ,  D01D5/0092 ,  H01M6/187 ,  H01M6/188 ,  H01M10/0562 ,  B29D99/005 ,  B29K2023/06 ,  B29K2023/12 ,  B29K2401/00 ,  B29L2031/755 ,  D10B2321/021 ,  D10B2321/022

摘要： A method of manufacturing an all-solid-state battery and an apparatus for manufacturing the same are provided. The method of manufacturing the all-solid-state battery includes: (a) a step of forming a non-woven fabric having a fiber made of a resin; (b) a step of applying a slurry containing solid electrolyte particles onto the non-woven fabric; (c) a step of drying the slurry on the non-woven fabric by a heater; (d) a step of pressurizing the slurry on the non-woven fabric by a roller; (e) a step of forming a positive electrode member on one surface of the solid electrolyte membrane; and (f) a step of forming a negative electrode member on the other surface of the solid electrolyte membrane. The step (a) is a step of forming the non-woven fabric by making a resin containing a polar filler fibrous by a laser electrospinning method. By such a method, the all-solid-state battery (a laminated body of a positive electrode member, a solid electrolyte membrane, and a negative electrode member) can be efficiently manufactured.

公开(公告)号：US12077885B2

公开(公告)日：2024-09-03

申请号：US17627414

申请日：2020-07-15

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education ,  Ri.MED Foundation

发明人： Antonio D'Amore ,  Daniel McKeel ,  William R. Wagner

IPC分类号： D02G3/26 ,  A61F2/24 ,  D01D5/00 ,  D02G3/02 ,  D02G3/36 ,  D02G3/44 ,  D07B1/02 ,  D07B3/00

CPC分类号： D02G3/26 ,  D01D5/0076 ,  D02G3/02 ,  D02G3/36 ,  D02G3/448 ,  D07B1/02 ,  D07B3/00 ,  A61F2/2457 ,  D07B2201/104 ,  D07B2201/2057 ,  D07B2201/2066 ,  D07B2201/2092 ,  D07B2205/2039 ,  D07B2205/2064 ,  D10B2331/10 ,  D10B2509/04

摘要： Provided herein is an electrodeposition apparatus for producing long polymeric threads, yarns, or ropes. A method of preparing long polymeric threads, yarns or ropes also is provided.

公开(公告)号：US12060656B2

公开(公告)日：2024-08-13

申请号：US17317658

申请日：2019-11-11

申请人： E-SPIN NANOTECH PRIVATE LIMITED

发明人： Shivendu Ranjan ,  Mahesh Kumar ,  Ravindra Kumar ,  Upama Tiwari ,  Shivam Sachan ,  Sandip Patil

IPC分类号： D01D5/00 ,  D01D4/02

CPC分类号： D01D5/0069 ,  D01D4/02

摘要： A capillary type multi-jet nozzle is provided for fabricating high throughput nanofibers by an electrospinning technique. The capillary type multi-jet nozzle includes a cap system with one or more pores and a crew system with a screw groove system. The cap system and the crew system are connected through a cap and crew system. The pores in the cap system are customized in count based on a requirement. The angle between the pores is reduced to make multiple non-interfering and non-hindering jets in less time. A TEFLON® gasket is used for proper tightening and sealing of the cap system and screw system. The cap system includes knurling at an outer surface for grip. The capillary type multi-jet nozzle is made of a conducting material to with stand a high voltage and is fabricated using micro-machining process.