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    CHEMILUMINESCENCE MICROFLUIDIC IMMUNOASSAY DEVICE AND METHODS OF USE THEREOF
    2.
    发明公开
    CHEMILUMINESCENCE MICROFLUIDIC IMMUNOASSAY DEVICE AND METHODS OF USE THEREOF 审中-公开

    公开(公告)号：US20240328957A1

    公开(公告)日：2024-10-03

    申请号：US18625514

    申请日：2024-04-03

    申请人： Burst Diagnostics LLC ,  Zymo Research Corporation

    发明人： Zach Call ,  Rose Nash ,  Alli Dolence ,  Charles Henry ,  Joseph Ollar ,  Xi Yu Jia

    IPC分类号： G01N21/76 ,  G01N33/58

    CPC分类号： G01N21/76 ,  G01N33/581

    摘要： A microfluidic assay device having a chemiluminescent testing assembly including a detection area, a sample inlet, and a microfluidic network including a first and second path extending to the detection area configured to capture a target analyte. When a fluid is provided to the sample inlet, a first portion of the fluid rehydrates a first dried reagent disposed along the first path to produce a first rehydrated reagent and a second portion of the fluid rehydrates a second dried reagent to produce a second rehydrated reagent. The first rehydrated reagent and the second rehydrated reagent are then sequentially delivered to the detection area by capillary-driven flow to perform the assay, where they react, optionally in the presence of a catalyst to form a chemiluminescent signal.

    Analysis control device, liquid chromatographic system and analysis execution method
    6.
    发明授权
    Analysis control device, liquid chromatographic system and analysis execution method 有权

    公开(公告)号：US11933771B2

    公开(公告)日：2024-03-19

    申请号：US17413808

    申请日：2018-12-20

    申请人： SHIMADZU CORPORATION

    发明人： Hiroyuki Minato ,  Masahide Gunji

    IPC分类号： G01N30/74 ,  G01N21/76 ,  G01N30/02 ,  G01N30/06 ,  G01N30/84 ,  G01N30/86

    CPC分类号： G01N30/74 ,  G01N30/8631 ,  G01N21/76 ,  G01N2030/027 ,  G01N30/06 ,  G01N30/84 ,  G01N30/86

    摘要： A first liquid sending controller of an analysis control device controls a first liquid sender such that a mobile phase is supplied to a fluorescence detector through an analysis column and a junction during an analysis of a sample. A sample introduction controller controls a sample introducer such that the sample is introduced into a mobile phase by the sample introducer at a position farther upstream than the analysis column during the analysis of the sample. The second liquid sending controller causes a second liquid sender to start supplying a fluorescent reaction liquid such that the fluorescent reaction liquid arrives at the junction later than a point in time at which supply of the mobile phase starts and before the sample introduced into the mobile phase arrives at the junction during the analysis of the sample. A generator generates a chromatogram based on an output signal of the fluorescence detector during the analysis of the sample.