CELL ANALYSIS USING CHEMFET SENSOR ARRAY-BASED SYSTEMS

    公开(公告)号:US20230129295A1

    公开(公告)日:2023-04-27

    申请号:US18145688

    申请日:2022-12-22

    摘要: Various cell analysis systems of the present teachings can measure the electrical and metabolic activity of single, living cells with subcellular addressability and simultaneous data acquisition for between about 10 cells to about 500,000 cells in a single analysis. Various sensor array devices of the present teachings can have sensor arrays with between 20 million to 660 million ChemFET sensors built into a massively paralleled array and can provide for simultaneous measurement of cells with data acquisition rates in the kilohertz (kHz) range. As various ChemFET sensor arrays of the present teachings can detect chemical analytes as well detect changes in cell membrane potential, various cell analysis systems of the present teachings also provide for the controlled chemical and electrical interrogation of cells.

    ION CONCENTRATION PROBE WITH ENHANCED SHIELDING

    公开(公告)号:US20220404306A1

    公开(公告)日:2022-12-22

    申请号:US17777698

    申请日:2020-11-17

    申请人: Thermo Orion Inc.

    摘要: A probe for measuring a sample solution includes an outer body configured to receive an operational amount of a reference solution, and a sensor assembly including an inner body at least a portion of which is located inside the outer body. A shield is positioned between the outer surface of the inner body and the inner surface of the outer body. The shield is configured to be in contact with the reference solution and extends above the top surface of the reference solution when the probe is filled with an operational amount of the reference solution.

    SANITARY SINGLE-USE PROCESS CONNECTION WITH INTEGRAL WET STORAGE FOR USE WITH PROCESS SENSORS

    公开(公告)号:US20220373496A1

    公开(公告)日:2022-11-24

    申请号:US17749481

    申请日:2022-05-20

    申请人: Rosemount Inc.

    摘要: A process fluid connector for a single-use process fluid sensing system is provided. The process fluid connector includes a pair of process fluid connections, each process fluid connection being configured to couple to a cooperative process fluid coupling. A process fluid conduit section is operably coupled to each of the process fluid connections. A sensor attachment port is coupled to the process fluid conduit section and is configured to receive and mount a process fluid sensor. A retractable fluid chamber is coupled to the process fluid conduit section and configured to provides wet storage for sensing component(s) of the process fluid sensor. A process fluid sensing system using the process fluid connector is also provided.

    DEVICE FOR ELECTROCHEMICAL MEASUREMENTS

    公开(公告)号:US20220291162A1

    公开(公告)日:2022-09-15

    申请号:US17629492

    申请日:2020-07-24

    IPC分类号: G01N27/28 G01N27/30

    摘要: The invention relates to a device for electrochemical measurements comprising an electrolytic fluid vessel characterized in that tire electrolytic fluid vessel (1) composes an electrolytic fluid chamber (5) having a lower opening (4) below which there is an essentially cylindrical portion (3) of the vessel with an essentially cylindrical closure (11), wherein the walls of the cylindrical portion (3) and the closure (11) are threaded in such a way that the closure can move in the cylindrical portion approaching the lower opening (4) and moving away from it, wherein the electrolytic fluid vessel has a side recess (6) for inserting between the closure (11) and the lower opening (4) the working electrode (12) with dimensions allowing the lower opening (4) to be closed with it.

    Inline sensor arrangement, and method for producing and commissioning said inline sensor arrangement

    公开(公告)号:US11339416B2

    公开(公告)日:2022-05-24

    申请号:US15986344

    申请日:2018-05-22

    摘要: The present disclosure relates to an inline sensor arrangement for the detection of measurement values of a measurand representing an analyte content of a measuring medium, which arrangement comprises: a sensor which is designed to generate and output a measurement signal correlated with the measurand, wherein the sensor has at least one sterile sensor element provided for contact with the measurement medium; and a housing surrounding the at least one sensor element, which housing encloses the sensor element in a chamber sealed tightly against an environment of the housing, and wherein the chamber contains inside it a gas volume that is designed such that an influence of harmful substances—in particular, of reactive nitrogen and/or oxygen species—on the at least one sensor element is largely prevented. The present disclosure further relates to a method for the production of said inline sensor arrangement, and for its commissioning.