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公开(公告)号：US11624735B2
公开(公告)日：2023-04-11
申请号：US17199812
申请日：2021-03-12
申请人： DIONEX SOFTRON GMBH
摘要： A method performed in a liquid chromatography system includes a metering device pushing a sample into a trap column. The metering device sucks in the sample from a sample reservoir, wherein the sucking in the sample from a sample reservoir precedes the step of pushing the sample into the trap column. The liquid chromatography system also includes a trap column and a metering device, wherein the system is adapted to assume a configuration allowing the metering device to push a sample into the trap column and wherein the metering device is adapted to push the sample into the trap column in this configuration, wherein the system is adapted to assume a configuration allowing the sample to be sucked into the system by means of the metering device. Furthermore, the invention relates to a use of the liquid chromatography system for liquid chromatography, in particular of high-pressure liquid chromatography.
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公开(公告)号：US11624734B2
公开(公告)日：2023-04-11
申请号：US17360131
申请日：2021-06-28
发明人： Michael O. Fogwill
摘要： A system capable of performing both single and multidimensional liquid chromatography includes a solvent delivery system, a sample injection system, a first dimension column path configured to perform a separation process in a first dimension, a second dimension column path configured to perform a separation process in a second dimension that is different than the first dimension, a valve system; and a sample injection system fluidically connected to the valve system. The valve system is configured to direct flow from a sample injection system to a first dimension column path when the valve system is in a first position, and to direct flow from the sample injection system to the second dimension column path without the flow path flowing through the first dimension column path in the chromatography system when the valve system is in a second position.
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公开(公告)号：US11598431B2
公开(公告)日：2023-03-07
申请号：US17290645
申请日：2019-11-01
发明人： Michael Keller , Audrey Schrock , Mark Tschann , Ashna Sandhu
IPC分类号： F16K11/074 , G01N30/20 , G01N30/46
摘要： A multiple channel selector valve includes a stator and a rotor that is rotatable with respect to the stator. The rotor face includes first and second fluid flow paths for transferring fluids to selected sets of passages in the stator. The fluid flow paths in the rotor face are specifically configured to accommodate high fluid flow rate regimes while reducing flow restriction.
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公开(公告)号：US11573211B2
公开(公告)日：2023-02-07
申请号：US17209502
申请日：2021-03-23
摘要： A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.
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公开(公告)号：US11567040B2
公开(公告)日：2023-01-31
申请号：US16760429
申请日：2018-10-26
摘要： Injector (40) for injecting a fluidic sample into a mobile phase in a sample separation apparatus (10), the injector (40) comprising a main flow path (100) between a fluid drive (20) and a sample separation device (30), wherein the fluid drive (20) is adapted to drive the mobile phase and the sample separation device (30) is adapted to separate the fluidic sample that is injected into the mobile phase, a discharge device (104) for discharging an, in particular predetermined, amount of the mobile phase from the main flow path (100), and a supply device (102) for supplying an, in particular predetermined, amount of the fluidic sample and/or of a solvent into the main flow path (100), wherein the discharged amount and the supplied amount compensate each other at least partially.
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公开(公告)号：US20230028446A1
公开(公告)日：2023-01-26
申请号：US17785984
申请日：2020-12-16
发明人： Yves Gamache , André Lamontagne , André Cliche
摘要： A diaphragm valve for gas analysis applications is provided. The valve includes a valve cap provided with a plurality of process conduits extending therethrough, a valve body engageable with the valve cap and having a body interface provided with a recess, a diaphragm positioned between the valve cap and valve body and having a process groove for circulating fluid therein, the process groove engaging the recess, a plunger assembly provided within the valve body, the plunger assembly comprising a plurality of plungers movable between a closed position wherein the plunger engages the diaphragm, and an open position wherein the plunger is spaced from the diaphragm, and an actuating assembly comprising a gas inlet to allow the injection of actuating gas therein, the actuating assembly comprising a purging system for purging a region located between the diaphragm and the body interface, whereby the actuating gas is used for purging the region.
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公开(公告)号：US20220341897A1
公开(公告)日：2022-10-27
申请号：US17730553
申请日：2022-04-27
发明人： Thomas Ortmann , Martin Seifried , Sam Wouters , Irina Spuling
摘要： An injector is configured for injecting a fluidic sample from an injector path into a mobile phase in a separation path between a fluid drive and a sample separation unit of a sample separation device. The injector includes a control unit configured for generating a first overpressure in a blocked first partial path of the injector path by a first pressure source, for generating a second overpressure in a blocked second partial path of the injector path by a second pressure source, for subsequently fluidically coupling the first partial path with the second partial path for generating an expansion stroke for releasing a gas bubble in the injector path, and for rinsing the released gas bubble from the injector path.
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公开(公告)号：US11467138B2
公开(公告)日：2022-10-11
申请号：US17543128
申请日：2021-12-06
申请人： VAON, LLC
摘要： A sensor structure is disclosed comprising at least four planar layers subsuming at least one cavity housed but not contained by overlapping apertures through at least two of the planar layers, wherein the at least one cavity comprises a plurality of chambers, and wherein at least one chamber of the plurality of chambers is configured to be in fluid coupling with at least one other chamber. The plurality of chambers may be defined by overlapping apertures through a plurality of the planar layers. The plurality of chambers may include a Gas Chromatograph (GC) column. The planar layers may be flexible flat glass. The planar layers may be fused together. The layers may be made with apertures through the layers disposed in a desired pattern to define complex structures by the apertures overlapping between abutting layers when the layers are stacked. The planar layers may be configured to admit ultraviolet light.
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公开(公告)号：US11454962B2
公开(公告)日：2022-09-27
申请号：US16611950
申请日：2018-04-23
发明人： Tim Tiemeyer , John Ruf , Michael Brew
摘要： An apparatus for controlling fluid flow, and in particular fluid flow through a microfluidic multi-port control valve assembly of a High Pressure Liquid Chromatography (HPLC) unit includes a localized data repository for storing cumulative wear indications of components of the apparatus. The stored information may travel with the apparatus to enable predictive failure of components of the apparatus.
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公开(公告)号：US20220236234A1
公开(公告)日：2022-07-28
申请号：US17583559
申请日：2022-01-25
IPC分类号： G01N30/20
摘要： Described is a rotary valve that includes a stator, a rotor and a plurality of sample channels. The stator includes a stator surface having an inlet port, an outlet port and a plurality of selectable ports. The rotor includes a rotor surface having a first rotor channel and a second rotor channel. The rotor is configurable in a plurality of rotor positions, each of which couples the inlet port to one of the selectable ports through the first rotor channel and couples the outlet port to another one of the selectable ports through the second rotor channel. The two selectable ports are coupled to each other through one of the sample channels. The rotor has a bypass state defined by a rotor position, or angular range of rotor positions, at which the inlet port is coupled to the outlet port through the second rotor channel.
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