公开(公告)号：US12130284B2

公开(公告)日：2024-10-29

申请号：US17318541

申请日：2021-05-12

申请人： Ventana Medical Systems, Inc.

发明人： Julia Ashworth-Sharpe ,  Brian D. Kelly ,  Mark Lefever ,  Nathan W. Polaske

IPC分类号： G01N33/533 ,  C09B11/24 ,  C09B23/08 ,  G01N33/532 ,  G01N33/58

CPC分类号： G01N33/533 ,  C09B11/24 ,  C09B23/083 ,  G01N33/532 ,  G01N33/582 ,  G01N33/583

摘要： Disclosed herein are novel chromogenic conjugates, the conjugates comprising at least two detectable moieties.

公开(公告)号：US12092635B2

公开(公告)日：2024-09-17

申请号：US18386066

申请日：2023-11-01

申请人： 10X GENOMICS, INC.

发明人： Tarjei Sigurd Mikkelsen ,  Eswar Prasad Ramachandran Iyer ,  Andrew Kohlway ,  Luigi Jhon Alvarado Martinez ,  Katherine Pfeiffer ,  Andrew D. Price

IPC分类号： G01N33/532 ,  C07K14/74 ,  C12N15/10 ,  C12N15/11 ,  C12N15/85 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6818 ,  C12Q1/6827 ,  C12Q1/6881 ,  C40B30/04 ,  C40B50/06 ,  C40B70/00 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/548 ,  G01N33/569 ,  G01N33/58

CPC分类号： G01N33/532 ,  C07K14/70539 ,  C12N15/1037 ,  C12N15/1055 ,  C12N15/1065 ,  C12N15/1075 ,  C12N15/11 ,  C12N15/85 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6818 ,  C12Q1/6827 ,  C12Q1/6881 ,  G01N33/5032 ,  G01N33/505 ,  G01N33/5304 ,  G01N33/5306 ,  G01N33/5308 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/548 ,  G01N33/56977 ,  G01N33/58 ,  C12N2310/20 ,  C12N2320/10 ,  C12Q2537/164 ,  C12Q2563/179 ,  C12Q2563/185 ,  C12Q2565/1015 ,  C40B30/04 ,  C40B50/06 ,  C40B70/00

摘要： The present disclosure provides methods of processing or analyzing a sample. A method for processing a sample may comprise hybridizing a probe molecule to a target region of a nucleic acid molecule (e.g., a ribonucleic acid (RNA) molecule), barcoding the probe-nucleic acid molecule complex, and performing extension, denaturation, and amplification processes. A method for processing a sample may comprise hybridizing first and second probes to adjacent or non-adjacent target regions of a nucleic acid molecule (e.g., an RNA molecule), linking the first and second probes to provide a probe-linked nucleic acid molecule, and barcoding the probe-linked nucleic acid molecule. One or more processes of the methods described herein may be performed within a partition, such as a droplet or well. One or more processes of the methods described herein may be performed on a cell, such as a permeabilized cell.

公开(公告)号：US11965877B2

公开(公告)日：2024-04-23

申请号：US14874553

申请日：2015-10-05

申请人： Bio-Rad Laboratories, Inc.

发明人： Michael Samuels ,  Jeffrey Charles Olson ,  Andrew Watson ,  Keith Brown ,  Darren R. Link

IPC分类号： G01N33/53 ,  C12N15/10 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6874 ,  C40B50/08 ,  G01N33/532 ,  G01N33/543 ,  G01N33/58

CPC分类号： G01N33/53 ,  C12N15/1075 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6874 ,  C40B50/08 ,  G01N33/532 ,  G01N33/5436 ,  G01N33/58 ,  C12Q2521/10 ,  C12Q2563/179 ,  C12Q2565/30 ,  G01N2458/10

摘要： The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.

公开(公告)号：US11958898B2

公开(公告)日：2024-04-16

申请号：US17176374

申请日：2021-02-16

申请人： New York University

发明人： Einar Sigurdsson

IPC分类号： C07K16/18 ,  A61K38/00 ,  A61P25/28 ,  G01N33/532

CPC分类号： C07K16/18 ,  A61P25/28 ,  G01N33/532 ,  A61K38/00 ,  C07K2317/622 ,  C07K2317/92 ,  G01N2800/2821

摘要： The present invention relates to antibody-based molecules (including single domain antibody fragment, scFv molecules, antibodies, antibody fragments, diabodies, and the epitope-binding domains thereof) that are capable of immunospecifically and selectively binding to the truncated Asp421 epitope of Tau. Such antibody-based molecules are useful to detect pathological Tau protein conformer if present in a biological sample, especially in conjunction with the diagnosis and/or treatment of Alzheimer's disease or other tauopathy, and thus provide a diagnostic for Alzheimer's disease and other Tau pathologies. The antibody-based molecules of the present invention have particular utility as diagnostic markers for, Alzheimer's disease and related tauopathies and as pharmaceutical compositions for the treatment of such conditions.

公开(公告)号：US20240102996A1

公开(公告)日：2024-03-28

申请号：US18516629

申请日：2023-11-21

申请人： BECTON, DICKINSON AND COMPANY

发明人： Olaf Zoellner ,  Eric Jensen ,  John Archdeacon ,  Brent S. Gaylord

IPC分类号： G01N33/532 ,  G01N33/58 ,  G06F7/10 ,  G06F16/248 ,  G06Q90/00 ,  G16B50/30 ,  G16C20/90

CPC分类号： G01N33/532 ,  G01N33/58 ,  G06F7/10 ,  G06F16/248 ,  G06Q90/00 ,  G16B50/30 ,  G16C20/90 ,  G16C20/10

摘要： Aspects of the present disclosure include systems for use in preparing a labelled biomolecule reagent. Systems according to certain embodiments include an input manager for receiving a request for a labelled biomolecule reagent, a memory for storing a dataset having a plurality of labelled biomolecule reagent storage identifiers, a processing module communicatively coupled to the memory and configured to identify one or more labelled biomolecule reagent storage identifiers from the dataset that corresponds to the labelled biomolecule reagent request and an output manager for providing the one or more identified labelled biomolecule reagent storage identifiers. A reagent preparatory apparatus for preparing the labelled biomolecule reagent from an activated biomolecule and activated label is also described. Methods for communicating and receiving a labelled biomolecule reagent request and preparing the subject labelled biomolecule reagents are also provided.

公开(公告)号：US20240093279A1

公开(公告)日：2024-03-21

申请号：US18467085

申请日：2023-09-14

申请人： SUREDX LLC

发明人： Claire Tianen MENG ,  Allan Haotian FANG ,  Yan ZHOU

IPC分类号： C12Q1/6848 ,  C12Q1/70 ,  G01N33/53 ,  G01N33/532 ,  G01N33/569

CPC分类号： C12Q1/6848 ,  C12Q1/70 ,  G01N33/5306 ,  G01N33/532 ,  G01N33/56983 ,  G01N2333/4712

摘要： An antibody-DNA conjugate set for detection of a target protein, comprising a first antibody-DNA conjugate having a first antibody which is capable of binding to the target protein; and a first DNA oligo linked to the first antibody; a second antibody-DNA conjugate having a second antibody which is capable of binding to the target protein; and a second DNA oligo linked to the second antibody.

公开(公告)号：US20240085415A1

公开(公告)日：2024-03-14

申请号：US18307749

申请日：2023-04-26

申请人： Quidel Corporation

发明人： Peter Yan-Guo Ren ,  Stewart Hoelscher ,  Cristian Alberto ,  Stephanie Pinedo ,  Jason McClure ,  Hyunjin Kim

IPC分类号： G01N33/569 ,  G01N33/532

CPC分类号： G01N33/56944 ,  G01N33/532 ,  G01N2400/10 ,  G01N2469/10

摘要： An enzymatic extraction agent, as well as methods, compositions and kits for detecting Group A streptococcus in a biological sample, which involve the enzymatic agent, are described.

公开(公告)号：US11921021B2

公开(公告)日：2024-03-05

申请号：US17462997

申请日：2021-08-31

申请人： Kabushiki Kaisha Toshiba

发明人： Hiroshi Hamasaki ,  Yoshiaki Sugizaki

IPC分类号： G01N33/68 ,  A01N1/02 ,  B01L3/00 ,  C07C309/65 ,  C07C309/73 ,  G01N1/40 ,  G01N21/33 ,  G01N21/64 ,  G01N27/414 ,  G01N33/52 ,  G01N33/532 ,  G01N33/543 ,  G01N33/569 ,  G01N33/72

CPC分类号： G01N1/4077 ,  G01N27/4141

摘要： A gas concentration device includes a first container, a second container, a pressure control device, and a path. The first container includes a first space surrounded by a first partition wall and stores a specimen, and a pressure inside the first space is reduced. The second container is airtightly connected to the first container by a first path and has a second space surrounded by a second partition wall and stores a gas flowing in from the first space. The pressure control device reduces a volume of the second space. A gas inside the second space is discharged through a second path.

公开(公告)号：US20240060968A1

公开(公告)日：2024-02-22

申请号：US18386066

申请日：2023-11-01

申请人： 10X GENOMICS, INC.

发明人： Tarjei Sigurd Mikkelsen ,  Eswar Prasad Ramachandran Iyer ,  Andrew Kohlway ,  Luigi Jhon Alvarado Martinez ,  Katherine Pfeiffer ,  Andrew D. Price

IPC分类号： G01N33/532 ,  C07K14/74 ,  C12N15/10 ,  C12N15/11 ,  C12N15/85 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6818 ,  C12Q1/6827 ,  C12Q1/6881 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/548 ,  G01N33/569 ,  G01N33/58

CPC分类号： G01N33/532 ,  C07K14/70539 ,  C12N15/1037 ,  C12N15/1055 ,  C12N15/1065 ,  C12N15/1075 ,  C12N15/11 ,  C12N15/85 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6818 ,  C12Q1/6827 ,  C12Q1/6881 ,  G01N33/5032 ,  G01N33/505 ,  G01N33/5304 ,  G01N33/5306 ,  G01N33/5308 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/548 ,  G01N33/56977 ,  G01N33/58 ,  C12N2310/20 ,  C12N2320/10 ,  C12Q2537/164 ,  C12Q2563/179 ,  C12Q2563/185 ,  C12Q2565/1015 ,  C40B30/04

摘要： The present disclosure provides methods of processing or analyzing a sample. A method for processing a sample may comprise hybridizing a probe molecule to a target region of a nucleic acid molecule (e.g., a ribonucleic acid (RNA) molecule), barcoding the probe-nucleic acid molecule complex, and performing extension, denaturation, and amplification processes. A method for processing a sample may comprise hybridizing first and second probes to adjacent or non-adjacent target regions of a nucleic acid molecule (e.g., an RNA molecule), linking the first and second probes to provide a probe-linked nucleic acid molecule, and barcoding the probe-linked nucleic acid molecule. One or more processes of the methods described herein may be performed within a partition, such as a droplet or well. One or more processes of the methods described herein may be performed on a cell, such as a permeabilized cell.

公开(公告)号：US11867692B2

公开(公告)日：2024-01-09

申请号：US17240497

申请日：2021-04-26

申请人： DG Group S.P.A.

发明人： Dino Radice

IPC分类号： G01N33/68 ,  G01N21/33 ,  G01N21/64 ,  G01N33/52 ,  C07C309/65 ,  C07C309/73 ,  A01N1/02 ,  G01N1/40 ,  G01N33/543 ,  G01N33/532 ,  G01N33/569

CPC分类号： G01N33/521 ,  G01N33/532 ,  G01N33/56911

摘要： A colorimetric sensor for detecting bacteria and/or viruses includes one or more layers having a photonic crystal structure, a functional layer comprising a nanomaterial capable of generating bacteria- and/or viruses-bioresponsive surface plasmon overlapping the one or more layers having the photonic crystal structure. The bacteria- and/or viruses-bioresponsive nanomaterial of the functional layer is doped with proteinic substances or antibodies acting as virus receptors, or the colorimetric sensor comprises a receptor layer comprising proteinic substances or antibodies acting as virus receptors. The functional layer and receptor layer overlap each other. Alternatively, or in addition to, the colorimetric sensor comprises a plasmonic nanostructured layer comprising nanostructures such to generate plasmonic colors, overlapping the one or more layers having the photonic crystal structure.