公开(公告)号：US20240361324A1

公开(公告)日：2024-10-31

申请号：US18586774

申请日：2024-02-26

申请人： Ahmed Fadiel-Metwaly ,  Frederick Naftolin

发明人： Ahmed Fadiel-Metwaly ,  Frederick Naftolin

IPC分类号： G01N33/574 ,  G01N21/59 ,  G01N33/543 ,  G01N33/58

CPC分类号： G01N33/57449 ,  G01N21/59 ,  G01N33/543 ,  G01N33/581 ,  G01N2333/7151 ,  G01N2470/06

摘要： p80 is a cancer/proliferation-related protein identified as being present in bodily fluids or tissues (including blood) of humans or animals afflicted with pre-malignant, malignant cells/tissues or proliferative conditions. The methods of the present disclosure provide a new diagnostic marker for screening of cancers and proliferative conditions. The present application discloses screening, diagnosis, and monitoring of these conditions by novel Point-of-Service tests. The addition of p80-bound tubulin testing is also claimed. Additionally, the present application discloses targeted treatment of cancer and proliferative conditions utilizing p80 binding agents, via a variety of delivery vehicles such as nanoparticles. The claims apply to application in domestic or wild animals.

公开(公告)号：US20240361308A1

公开(公告)日：2024-10-31

申请号：US18648822

申请日：2024-04-29

申请人： Microsensor Labs, LLC

发明人： Peng Liu ,  Zerikhun Filatov

IPC分类号： G01N33/543 ,  G01N33/569 ,  G01N35/00

CPC分类号： G01N33/54326 ,  G01N33/56916 ,  G01N35/0098

摘要： A system and method for detecting, enumerating, or extracting microorganisms in a sample is disclosed. Target microorganisms, such as Salmonella bacteria, may be of interest. Magnetic beads may be bound to the target microorganisms. After which, the bead-bound cells may be isolated. For example, a magnetic field may be applied in order to separate the target cells (with the magnetic beads attached thereto) and move then to a predetermined section of the well. Agar, or other immobilizing agent, may be added to the wells in order to immobilize the target cells. After which, the target cells are incubated and periodically analyzed to determine whether the target cells are growing, thereby indicating that the microorganisms are contained within the well.

公开(公告)号：US12131802B2

公开(公告)日：2024-10-29

申请号：US15443102

申请日：2017-02-27

申请人： OPKO Diagnostics, LLC ,  Oy Arctic Partners Ab

发明人： Andrew J. Vickers ,  Peter T. Scardino ,  Hans Lilja ,  Vincent Linder ,  David Steinmiller

IPC分类号： G16B20/00 ,  B01L3/00 ,  C12Q1/6886 ,  G01N33/543 ,  G01N33/574 ,  G01N33/68 ,  G16B40/00 ,  G16H10/40 ,  G16H50/20 ,  G16H50/30

CPC分类号： G16B20/00 ,  B01L3/502 ,  B01L3/502715 ,  B01L3/502761 ,  C12Q1/6886 ,  G01N33/54366 ,  G01N33/57434 ,  G01N33/6893 ,  G16B40/00 ,  G16H10/40 ,  G16H50/20 ,  G16H50/30 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0487 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N2333/96455

摘要： Methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided. More particularly, this disclosure relates to methods and apparatuses for providing the models and employing the models for predicting risk of prostate cancer and/or predicting prostate gland volume. The methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided using, at least in part, information from a panel of kallikrein markers.

公开(公告)号：US20240353405A1

公开(公告)日：2024-10-24

申请号：US18682794

申请日：2022-08-08

申请人： Agency for Science, Technology and Research ,  Singapore Heavy Engineering Pte Ltd

发明人： Laura SUTARLIE ,  Xiaodi SU ,  Alan Jenting SHE ,  Khin Moh Moh AUNG

IPC分类号： G01N33/569 ,  G01N33/543 ,  G01N35/10

CPC分类号： G01N33/56911 ,  G01N33/54386 ,  G01N35/1002 ,  G01N35/1067 ,  G01N35/1095

摘要： The disclosure concerns bacterial cell counting devices, systems and methods thereof. The bacterial cell counting device comprises at least one cartridge for containing reagents; an inlet for introducing a sample containing bacterial cells into the device; an optofluidic chip separately in fluid communication with the cartridge and the inlet; a filter strip passing through the optofluidic chip and in fluid communication with the cartridge and the inlet, the filter strip for trapping or retaining bacterial cells on its surface such that the bacterial cells can interact with the reagents as they flow through the filter strip; and a controller for controlling a sequential flow of reagents and sample to the filter strip via the optofluidic chip. The optofluidic chip is capable of detecting a colorimetric and/or fluorescence output emitted from the bacterial cells modified by the reagents in order for the bacterial cells to be quantified relative to a control.

公开(公告)号：US20240353339A1

公开(公告)日：2024-10-24

申请号：US18683345

申请日：2022-08-19

申请人： Agency for Science, Technology and Research

发明人： Malini Olivo ,  Jayakumar Perumal ,  Dinish Unnimadhava Kurup Soudamini Amma

IPC分类号： G01N21/65 ,  G01N33/543 ,  G01N33/68

CPC分类号： G01N21/658 ,  G01N33/54346 ,  G01N33/54373 ,  G01N33/6893 ,  G01N2333/525 ,  G01N2333/54 ,  G01N2333/96419

摘要： A biocompatible SERS-active polymer membrane configured to detect biomarkers in a sample. The biocompatible SERS-active polymer membrane includes a flexible and porous polymer membrane and SERS-active nanoparticles formed on the flexible and porous polymer membrane, where the flexible and porous polymer membrane includes cellulose or an elastomeric polymer. Also disclosed herein is a method of forming the biocompatible SERS-active polymer membrane and a method of determining a state of wound healing in a diabetic individual involving the use of the biocompatible SERS-active polymer membrane.

公开(公告)号：US12123868B2

公开(公告)日：2024-10-22

申请号：US18167557

申请日：2023-02-10

申请人： Alentic Microscience Inc.

发明人： Alan Marc Fine

IPC分类号： G01N33/53 ,  G01N21/77 ,  G01N33/50 ,  G01N33/536 ,  G01N33/543 ,  G01N33/58

CPC分类号： G01N33/5302 ,  G01N21/77 ,  G01N33/5094 ,  G01N33/536 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/582 ,  G01N33/585

摘要： An indicator of a first type and an indicator of a second type are attached to a unit of a chemical component in a sample to form a first multi-indicator complex. The first multi-indicator complex includes the unit of the chemical component, the indicator of the first type, and the indicator of the second type. The indicator of the first type and the indicator of the second type have different discernible characteristics. An image of the sample, including the first multi-indicator complex corresponding to the unit of the chemical component, is captured by an image sensor. Based on a first image of the sample, a count is generated of multi-indicator complexes that include an indicator of the first type and an indicator of the second type, including the first multi-indicator complex. Based on the count, a presence or a level of the chemical component in the sample is identified.

公开(公告)号：US20240345021A1

公开(公告)日：2024-10-17

申请号：US18542582

申请日：2023-12-15

申请人： Richard POSTREL

发明人： Richard POSTREL

IPC分类号： G01N27/414 ,  G01N33/543

CPC分类号： G01N27/4141 ,  G01N33/5438

摘要： The present invention provides a portable handheld medical screening device designed to facilitate health, medical research, and health-security screening measures at hospitals, emergency rooms, medical facilities, offices, meeting rooms, sports training facilities, health clubs, restaurants, small shops and for service providers, etc., i.e., places associated with healthcare and interactions between persons unknown to each other in settings where disease, public health, research data collection, disease contagion, and/or disease detection and/or monitoring are a concern. The invention provides several formats of self-contained devices with flexible attachment that collects ambient emissions, especially volatile compounds, produced by a subject (medical patient or one or more persons interacting with each other). In a clinical setting, the device monitors gas compounds produced by the subject, analyzes the monitored gases to determine patterns of emitted gases, compares these patterns to libraries of patterns associated with a disease or condition, and reports the associations.

公开(公告)号：US20240344128A1

公开(公告)日：2024-10-17

申请号：US18750834

申请日：2024-06-21

申请人： FUNDACIÓN DEL SECTOR PÜBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS II

发明人： Manuel SERRANO MARUGAN ,  Susana LLANOS GIRÓN ,  Andy Selim CHAIB

IPC分类号： C12Q1/6876 ,  C07K16/28 ,  G01N33/543

CPC分类号： C12Q1/6876 ,  C07K16/2827 ,  G01N33/54306 ,  C07K2317/76 ,  C12Q2600/158

摘要： Identification and elimination of damaged and/or senescent cells.
This invention relates to methods of detecting cells over-expressing of Programmed Death Ligand 2 (PD-L2), in particular, damaged and/or senescent cells, and the identification thereof. The invention also extends to the use of antagonists of Programmed Death Ligand 2 (PD-L2) and Programmed Cell Death Protein 1 (PD-1) interaction, or inhibitors of PD-1 or PD-L2 expression to eliminate damaged and/or senescent cells, which are involved in numerous pathologies and aging, and are also produced as a result of exposure to toxic substances.

公开(公告)号：US20240342678A1

公开(公告)日：2024-10-17

申请号：US18620775

申请日：2024-03-28

申请人： Celldom, Inc. ,  The Regents of the University of California

发明人： Natalia Tkachenko ,  Eugene Tkachenko ,  Alexander Groisman ,  Edgar Gutierrez

IPC分类号： B01J19/00 ,  B01L3/00 ,  C12N15/10 ,  C12Q1/02 ,  C40B40/06 ,  G01N33/50 ,  G01N33/543

CPC分类号： B01J19/0046 ,  B01L3/5085 ,  C12N15/1013 ,  C12Q1/02 ,  C40B40/06 ,  G01N33/5005 ,  G01N33/54366 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00648 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858

摘要： The present invention provides methods, systems and kits for performing microwell analysis in sealed small volumes. The microwells of the invention are sealed through the pairing of microwell and bead geometry wherein the diameter of the beads is greater than the diameter of the bottom of the microwells. Loading the beads into the microwells seals samples within an analytical space between the bottom of a nested bead and the bottom of the subject microwell.

公开(公告)号：US20240337662A1

公开(公告)日：2024-10-10

申请号：US18747878

申请日：2024-06-19

申请人： Adeptrix Corp.

发明人： Vladislav B. Bergo

IPC分类号： G01N33/68 ,  C07K1/30 ,  G01N33/543

CPC分类号： G01N33/6848 ,  C07K1/306 ,  G01N33/54313 ,  C07K1/30

摘要： Methods for performing bead-based analytical assays for detecting changes in abundance of target analytes in biological samples are disclosed. In an embodiment, a method involves eluting bead-captured analytes from a bead array under conditions that preserve spatial localization of the eluted analytes.