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公开(公告)号：US20230139301A1
公开(公告)日：2023-05-04
申请号：US17910927
申请日：2021-02-03
发明人： Daisuke EBIHARA , Shinya MATSUOKA
摘要： To provide an automatic analyzer capable of relaxing the effect of a previously created mixed liquid when a new mixed liquid is created. An automatic analyzer according to the present disclosure: is configured so as to create a second mixed liquid after a first mixed liquid is created; and introduces a relaxation reagent to relax the effect of a first reagent remaining in a mixed liquid chamber when the second mixed liquid is created into the mixed liquid chamber on the basis of characteristics of the first mixed liquid.
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公开(公告)号：US20230136020A1
公开(公告)日：2023-05-04
申请号：US17918447
申请日：2020-05-27
摘要： The present invention provides a nucleic acid analysis device that, even when a plurality of flow cells is handled, does not require an increase in the required movement amount, and can be reduced in size by reducing the size of a stage mechanism. This nucleic acid analysis device is characterized by having a sample container containing a nucleic acid sample to be analyzed, an imaging means for observing the nucleic acid sample, and a stage mechanism for moving the sample container, and is characterized in that the stage mechanism has two translation means and at least one rotation means, one of the two translation means is disposed on the upper surface of the rotation means, and the other is disposed on the lower surface of the rotation means.
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公开(公告)号：US11639942B2
公开(公告)日：2023-05-02
申请号：US17411720
申请日：2021-08-25
发明人： Zhihong Wang , Fating She , Peng Zhou
摘要： A sample analyzer, comprising a sample storage region, a sample-drawing channel, and a transport mechanism; the sample storage region being provided with a plurality of storage channels; the sample-drawing channel is provided with a sample-drawing position; the transport mechanism comprises an engagement slot, an actuation mechanism and a first moving mechanism; the engagement slot and the actuation mechanism are fixed on the first moving mechanism, the actuation mechanism comprises an actuator and a second moving mechanism, the actuator is drivable by at least one of the first moving mechanism and the second moving mechanism to realize the movement of the sample holder between the storage channels and the engagement slot; during sample drawing, the first moving mechanism drives the engagement slot to move to the sample-drawing channel, the actuation mechanism enables samples to pass through the sample-drawing position and to make a stop for sample drawing.
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公开(公告)号：US20230129016A1
公开(公告)日：2023-04-27
申请号：US18145185
申请日：2022-12-22
申请人： Clear Labs, Inc.
发明人： Sasan AMINI , Ramin KHAKSAR , Michael TAYLOR , Shadi SHOKRALLA , Christopher HANEY , Pavan VAIDYANATHAN , Stephanie POLLARD , Adam ALLRED , Sima MORTAZAVI , David TRAN , Hossein NAMAZI , Julius BARSI
IPC分类号： G16B35/10 , G16B25/20 , G16B30/20 , G16B35/20 , C12N15/10 , C12Q1/6806 , C12Q1/6869 , G01N35/00 , G01N35/10
摘要： Provided herein are automated apparatus and methods for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by library preparation and sequencing.
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公开(公告)号：US20230128571A1
公开(公告)日：2023-04-27
申请号：US17801672
申请日：2021-02-23
申请人： Biotage AB
发明人： Douglas T. GJERDE , Olof ERIKSSON , Juha ESALA , Johan ASPLUND
IPC分类号： G01N35/10
摘要： The present invention is an automated separation system comprised of a liquid handling device and one or more pipette tip columns, wherein the liquid handling device is equipped with two or more nozzles arranged to respectively receive a pipette tip column comprising separation media. Further, the system includes means for applying either high positive or negative pressure to the column inside chamber above the column bed, enabling aspiration and dispensing into and out of each pipette tip column. To enable sealing to the pressures used to move liquid through the column bed without inadvertently ejecting the column from the nozzle during the separation process, each nozzle has been provided with at least one annular protrusion arranged to engage with the inside of a substantially evenly tapered pipette tip column, without any corresponding recess. Each nozzle may be provided with slide ejector to enable the removal of a pipette tip column.
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公开(公告)号：US11635444B2
公开(公告)日：2023-04-25
申请号：US16737233
申请日：2020-01-08
申请人： JEOL Ltd.
发明人： Tsuyoshi Yaita
摘要： A feature amount extraction unit outputs, as a data series, a feature amount of time-series data of an oscillation frequency of an AC signal of an oscillation circuit until a certain time elapses from when a dispensing probe starts to be lowered. Then, a bubble contact determination processing unit determines whether a liquid level has been normally detected based on a correlation between a waveform of the data series of the feature amount and an abnormal waveform model. Further, based on a determination result, a second controller determines a deviation between a tip portion of the dispensing probe and the liquid level in a container and a factor of the deviation.
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公开(公告)号：US20230109714A1
公开(公告)日：2023-04-13
申请号：US18056680
申请日：2022-11-17
申请人： HOLOGIC, INC.
发明人： Barry F. Hunt , Raymond Jenoski , Ryan Oliva , Michael Cordeiro , Eric Grimes
摘要： An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, an analytic element positioner having an analytic element holder configured to releasably grip an analytic element, and a specimen transfer device carried by the tool head, wherein the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample container held in the sample container holder, and to transfer the obtained specimen to an analytic element held by the analytic element holder, respectively, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.
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公开(公告)号：US20230095937A1
公开(公告)日：2023-03-30
申请号：US18075707
申请日：2022-12-06
IPC分类号： G01N35/10
摘要： To provide a high-throughput automatic analysis apparatus at a lower cost. The automatic analysis apparatus includes an incubator which accommodates a plurality of reaction vessels; a specimen dispensing mechanism which dispenses a specimen into each of the plurality of reaction vessels; a mounting unit which mounts a dispensing tip on the specimen dispensing mechanism; a suction unit which sucks a specimen from a specimen vessel containing the specimen by means of the specimen dispensing mechanism having the dispensing mounted thereon; a discharging unit which is provided in the incubator and discharges the specimen from the specimen dispensing mechanism to the reaction vessel; a disposal unit which discards the dispensing tip; a sensor which detects whether the dispensing tip is mounted to the specimen dispensing mechanism; and a control unit which controls the specimen dispensing mechanism. The mounting unit, the suction unit, the discharging unit, and the disposal unit are arranged along a movement path of the specimen dispensing mechanism. The sensor is arranged so as to be able to detect the dispensing tip at a position sandwiched between any two of the mounting unit, the suction unit, the discharging unit, and the disposal unit.
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公开(公告)号：US11614454B2
公开(公告)日：2023-03-28
申请号：US17129522
申请日：2020-12-21
发明人： Rolf Silbert , David Opalsky , David Aaron Buse , Robert J. Rosati , Olev Tammer , Richard Capella , Matthias Merten
IPC分类号： G01N1/28 , G01N1/31 , G01N35/10 , G01N35/02 , G01N35/00 , G01F23/263 , G01N35/04 , C40B60/12
摘要： A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and an elevator with a chuck guide that contact the container holder as the chuck is lowered by the elevator to position the chuck with respect to the cap of the container held in the holder and to hold jaws of the container holder in a closed position. In embodiment, the chuck guide includes a yoke with opposed arms and spindles located near distal ends of the arms that engage beveled shoulders of the container holder.
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公开(公告)号：US11613427B2
公开(公告)日：2023-03-28
申请号：US15768759
申请日：2016-10-28
申请人： BODITECH MED INC.
发明人： Byeong Chul Kim , Young Haeng Lee , Kyong Hwa Chong , Min Hwan Lee , Yu Jin Park
IPC分类号： B65G47/06 , B65G47/26 , B65G47/82 , G01N21/25 , G01N35/04 , G01N21/17 , G01N35/02 , G01N1/10 , G01N1/18 , G16H10/40 , G01N35/00 , G01N35/10
摘要： The present invention relates to a horizontal-flow-type apparatus for automatically transporting reagent cartridges. The apparatus includes: a magazine (110) in which a plurality of reagent cartridges (1) is stacked; a conveyer belt (120) having a plurality of separating projections (121) arranged in a conveying direction to horizontally separately convey the reagent cartridges (1); a driving motor (130) for driving the conveyer belt (120); a feeding unit (140) for feeding the reagent cartridges (1) stacked in the magazine (110) onto the conveyer belt (120); an examining unit (150) disposed over the front end of the conveyer belt (120) to examine the reagent cartridges (1); and reagent cartridge aligning members (161, 162) disposed in the conveying line of the conveyer belt (120), opposite to the examining unit (150), to align the reagent cartridges (1) in position.
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