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公开(公告)号：US11635610B2
公开(公告)日：2023-04-25
申请号：US17322903
申请日：2021-05-18
摘要： A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a micro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample.
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公开(公告)号：US20230100225A1
公开(公告)日：2023-03-30
申请号：US17802350
申请日：2020-03-09
发明人： Akira MASUYA , Tadao YABUHARA
摘要： A microscopic image capturing method includes: emitting a light beam from a light beam light source; detecting a spot image by a camera or a photodiode; focusing the spot image by an objective lens actuator moving an objective lens in the optical axis direction of the light beam with respect to a sample container; determining by a reflective surface identification unit whether the light beam has been applied to a defect on the basis of the spot image; when it is determined that the light beam has been applied to the defect, moving by an XY stage the sample container with respect to the objective lens in a direction orthogonal to the optical axis of the light beam in accordance with a prescribed condition; and, when the light beam has not been applied to the defect, capturing a microscopic image of a sample by using an illuminator.
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公开(公告)号：US11604200B2
公开(公告)日：2023-03-14
申请号：US17813877
申请日：2022-07-20
摘要： A power off delay system and method is configured to delay termination of electrical power to a digital pathology device in a power off condition. If the apparatus includes a UPS, the power off delay system and method delays termination of electrical power when a power switch is turned off and when a catastrophic power failure occurs. During the delay of the termination of electrical power, the digital pathology device is configured to control the scanning stage system and the glass slide conveyor system and the slide rack conveyor system to place each of these systems into a known state and position all glass slides into a known position prior to the termination of electrical power to the digital pathology device. This allows the digital pathology device to resume normal operation upon power up.
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公开(公告)号：US20230060037A1
公开(公告)日：2023-02-23
申请号：US17793926
申请日：2021-01-27
IPC分类号： G06V20/69 , H04N5/232 , G06V10/10 , G06V10/82 , H04N5/225 , C12Q1/04 , G02B21/36 , G02B21/26 , G03H1/00
摘要： A system for the detection and classification of live microorganisms in a sample includes a light source and an incubator holding one or more sample-containing growth plates. A translation stage moves the image sensor and/or the growth plate(s) along one or more dimensions to capture time-lapse holographic images of microorganisms. Image processing software executed by a computing device captures time-lapse holographic images of the microorganisms or clusters of microorganisms on the one or more growth plates. The image processing software is configured to detect candidate microorganism colonies in reconstructed, time-lapse holographic images based on differential image analysis. The image processing software includes one or more trained deep neural networks that process the time-lapsed image(s) of candidate microorganism colonies to detect true microorganism colonies and/or output a species associated with each true microorganism colony.
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公开(公告)号：US20230051082A1
公开(公告)日：2023-02-16
申请号：US17884983
申请日：2022-08-10
IPC分类号： G01N33/483 , C12M1/34 , C12M1/32 , G02B21/36 , G02B21/26
摘要： Devices and methods to measure cells and/or tissue's contractile force are disclosed. Included is a mount with rigid, and non-rigid posts sized to flex. Determined is force exerted by contractile cells and tissues in a multiwell plate. The device is designed to fit inside individual wells with posts directed downwards. Posts are attached to a 3D printed circular mount with tabs for depth within the well. The mount has a window for medium changes while the device is positioned inside the well. The cells are seeded within a hydrogel. As the hydrogel condenses, cells/tissue wrap around the post's outside pulling non-rigid post toward rigid post. Inverted light microscope is used to determine deflection of non-rigid post inside the multiwell plate. Movement of the non-rigid post is measured using an acrylic ruler on an underside of the multiwell plate. Contractile forces of cells/tissue are determined using cantilever mechanics.
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公开(公告)号：US20230048374A1
公开(公告)日：2023-02-16
申请号：US17792475
申请日：2020-12-23
申请人： IOLIGHT LIMITED
发明人： Andrew Monk , Richard Williams
IPC分类号： G02B21/26
摘要： A microscope stage comprising a planar base (1) with two or more parallel grooves (2) formed extending in a first direction (5). A carriage (3) is mounted on the base with at least two projections (4) that slide in the grooves. The carriage receives a microscope slide or other sample holder (6). The carriage includes at least one guide and a biasing means (7) to urge the sample holder against the guide while permitting it to move relative to the guide in a second direction (8) orthogonal to the first direction.
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公开(公告)号：US20230020684A1
公开(公告)日：2023-01-19
申请号：US17783315
申请日：2020-12-02
申请人： CORNING INCORPORATED
IPC分类号： G01N21/958 , G01N21/88 , G02B21/12 , G02B21/26
摘要： Apparatuses and methods are described for detecting inclusions in glass. The apparatuses and methods employ a laser that is configured to project a laser sheet at a first angle from one side of a glass sheet, and a camera configured to capture images from a second angle from another side of the glass sheet. The glass sheet is moved thorough the laser sheet while the camera captures images. One or more processing devices execute image processing algorithms to identify areas of the glass sheet containing inclusions based on the captured images. In some examples, the identified areas of the glass sheet are revisited to confirm they contain inclusions.
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公开(公告)号：US20230014074A1
公开(公告)日：2023-01-19
申请号：US17857061
申请日：2022-07-04
发明人： Stefan CHRIST
IPC分类号： G02B21/26
摘要： A microscope includes: a sample chamber; a microscope stage arranged below the sample chamber, the microscope stage having a top surface for receiving a sample carrier in an examining position, in which a sample arranged on the sample carrier is microscopically examinable; a sample carrier storing unit arranged within the sample chamber for receiving the sample carrier in at least one storing position; and a sample carrier handling device for moving the sample carrier between the storing position and the examination position.
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公开(公告)号：US11549955B2
公开(公告)日：2023-01-10
申请号：US16875665
申请日：2020-05-15
申请人： SCOPIO LABS LTD.
发明人： Itai Hayut , Erez Na'Aman , Eran Small
摘要： A microscope system may comprise a plurality of microscope modules, a cassette for holding a plurality of slides, a slide loader configured to move the plurality of slides between the cassette and the plurality of microscope modules, and a processor coupled to the slide loader. The processor may be configured with instructions which, when executed, cause the slide loader to move a slide into or from a selected microscope module among the plurality of microscope modules. Various other methods, systems, and computer-readable media are also disclosed.
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公开(公告)号：US20230003988A1
公开(公告)日：2023-01-05
申请号：US17808380
申请日：2022-06-23
发明人： Heiko Stegmann
摘要： A sample holder system for holding a microscopic sample in a microscope system comprises a first and a second rotation element, which are rotatably connected to one another. The side surfaces of the two rotation elements in each case enclose an angle α, with the result that the rotation elements have a wedge-shaped cross section. The second rotation element is configured to receive a sample, while the first rotation element can be rotatably connected to a holder receiving surface. The rotation elements are each rotatable by an angle β about a rotation axis. The inclination of the third side surface on which the sample can be received is settable by combining all of the involved angles α and β.
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