BISPECIFIC BINDING MOLECULES THAT ARE CAPABLE OF BINDING CD137 AND TUMOR ANTIGENS, AND USES THEREOF

    公开(公告)号:US20240233818A1

    公开(公告)日:2024-07-11

    申请号:US18442857

    申请日:2024-02-15

    申请人: MacroGenics, Inc.

    IPC分类号: G11C13/00 G11C15/00

    摘要: The present invention is directed to binding molecules that possess one or more epitope-binding sites specific for an epitope of CD137 and one or more epitope-binding sites specific for an epitope of a tumor antigen (“TA”) (e.g., a “CD137×TA Binding Molecule”). In one embodiment, such CD137×TA Binding Molecules will be bispecific molecules, especially bispecific tetravalent diabodies, that are composed of two, three, four or more than four polypeptide chains and possessing two epitope-binding sites each specific for an epitope of CD137 and two epitope-binding sites each specific for an epitope of a TA. Alternatively, such CD137×TA Binding Molecules will be bispecific molecules, especially bispecific trivalent binding molecules composed of three or more polypeptide chains and possessing one or two epitope-binding sites each specific for an epitope of CD137 and one or two epitope-binding sites each specific for an epitope of a TA. The CD137×TA Binding Molecules of the invention are capable of simultaneous binding to CD137, and a TA. The invention is directed to pharmaceutical compositions that contain any such CD137×TA Binding Molecules. The invention is additionally directed to methods for the use of such molecules in the treatment of cancer and other diseases and conditions. The invention also provides novel CD137-binding molecules, and HER2/neu-binding molecules, as well as derivatives thereof and uses thereof.

    Firmware repair for three-dimensional NAND memory

    公开(公告)号:US11892902B2

    公开(公告)日:2024-02-06

    申请号:US17470342

    申请日:2021-09-09

    发明人: YanLan Liu

    摘要: The present disclosure provides a content addressable memory (CAM) for repairing firmware of multi-plane read operations in a flash memory device. The CAM comprises a set of CAM registers configured to store a mapping table. The mapping table comprises a plurality of old addresses, each old address corresponding to a new address. The CAM also comprises N comparators coupling to the set of CAM registers, and configured to compare the old addresses with N input signals for performing the multi-plane read operations on N memory planes, wherein N is an integer greater than 1. The CAM further comprises N multiplexers coupling to the N comparators respectively and to the set of CAM registers, and configured to generate N output signals for the multi-plane read operations. At least one of the N output signals comprises the new address according to the mapping table and a comparison output by the comparators.

    FIRMWARE REPAIR FOR THREE-DIMENSIONAL NAND MEMORY

    公开(公告)号:US20220391280A1

    公开(公告)日:2022-12-08

    申请号:US17470342

    申请日:2021-09-09

    发明人: YanLan Liu

    摘要: The present disclosure provides a content addressable memory (CAM) for repairing firmware of multi-plane read operations in a flash memory device. The CAM comprises a set of CAM registers configured to store a mapping table. The mapping table comprises a plurality of old addresses, each old address corresponding to a new address. The CAM also comprises N comparators coupling to the set of CAM registers, and configured to compare the old addresses with N input signals for performing the multi-plane read operations on N memory planes, wherein N is an integer greater than 1. The CAM further comprises N multiplexers coupling to the N comparators respectively and to the set of CAM registers, and configured to generate N output signals for the multi-plane read operations. At least one of the N output signals comprises the new address according to the mapping table and a comparison output by the comparators.

    METHOD AND APPARATUS FOR EFFICIENT DEFLATE DECOMPRESSION USING CONTENT-ADDRESSABLE DATA STRUCTURES

    公开(公告)号:US20220200623A1

    公开(公告)日:2022-06-23

    申请号:US17133609

    申请日:2020-12-23

    申请人: Intel Corporation

    摘要: Apparatus and method for efficient compression block decoding using content-addressable structure for header processing. For example, one embodiment of an apparatus comprises: a header parser to extract a sequence of tokens and corresponding length values from a header of a compression block, the tokens and corresponding length values associated with a type of compression used to compress a payload of the compression block; and a content-addressable data structure builder to construct a content-addressable data structure based on the tokens and length values, the content-addressable data structure builder to write an entry in the content-addressable data structure comprising a length value and a count value, the count value indicating a number of times the length value was previously written to an entry in the content-addressable data structure.

    Ternary content addressable memory and memory cell thereof

    公开(公告)号:US11328775B2

    公开(公告)日:2022-05-10

    申请号:US17065516

    申请日:2020-10-07

    IPC分类号: G11C15/00 G11C15/04

    摘要: A ternary content addressable memory and a memory cell thereof are provided. The ternary content addressable memory cell includes a first transistor and a second transistor. The first transistor has a gate to receive a selection signal. A first end of the first transistor is coupled to a match line. A second end of the first transistor is coupled to a source line. The second transistor has a gate to receive an inverted selection signal. A first end of the second transistor is coupled to the match line. A second end of the second transistor is coupled to the source line. The first and second transistors have charge storage structures.