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公开(公告)号：US20240363323A1
公开(公告)日：2024-10-31
申请号：US18309565
申请日：2023-04-28
申请人： KARSA OY
CPC分类号： H01J49/049 , H01J49/0031
摘要： The present disclosure concerns a desorption device including a mesh structure forming a mesh filter the mesh being formed by back-bone material being coated by gas adsorbing and/or absorbing absorbent. The present disclosure concerns also a desorption device hosting device to hold such desorption device in sampling, and a system as well as a chemical analysis method using such desorption devices in the sampling of a sample being analyzed.
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公开(公告)号：US20240363321A1
公开(公告)日：2024-10-31
申请号：US18768828
申请日：2024-07-10
申请人： Micromass UK Limited
CPC分类号： H01J49/0031 , H01J49/0009 , H01J49/004 , H01J49/005 , H01J49/0072 , H01J49/025
摘要： A method of mass spectrometry is disclosed comprising: performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises: mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses transmitted therefrom is varied with time; and mass analysing ions.
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3.发明公开公开(公告)号：US20240355686A1
公开(公告)日：2024-10-24
申请号：US18759691
申请日：2024-06-28
申请人： Daniel Pierce RADIN
发明人： Daniel Pierce RADIN
CPC分类号： H01L22/12 , G01N21/94 , G01N21/9501 , H01J49/0036 , H01J49/0422 , H01J49/105
摘要： Disclosed herein are compositions and methods employing AMPA Receptor (AMPR) antagonist compounds to treat AMPAR positive cancers in mammalian subjects. In certain detailed embodiments the AMPAR antagonist is a Perampanel compound, effective to mediate potent oncolytic effects to prevent or reduce the severity or recurrence of a variety of cancer forms, including central nervous system (CNS) cancers.
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公开(公告)号：US12125693B2
公开(公告)日：2024-10-22
申请号：US18378247
申请日：2023-10-10
发明人： Robert Graham Cooks
CPC分类号： H01J49/165 , H01J49/0013
摘要： The invention generally relates to systems and methods for conducting reactions and screening for reaction products.
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公开(公告)号：US12125692B2
公开(公告)日：2024-10-22
申请号：US17345549
申请日：2021-06-11
发明人： Alexander A. Makarov , Eloy R. Wouters , Joshua A. Silveira , Mikhail G. Skoblin , Viacheslav Kozlovskiy
CPC分类号： H01J49/066 , H01J49/0031 , H01J49/24
摘要： A mass spectrometry method comprises: (1) introducing ions and gas into an first electrode section of an ion transport apparatus through a slot of an ion transfer tube, the ion tunnel section comprising a first longitudinal axis that is contained within a slot plane of the ion transfer tube, the first longitudinal axis not intersecting an outlet of the ion transfer tube, wherein the apparatus further comprises: (a) a second electrode section configured to receive the ions from the first electrode section and comprising a second longitudinal axis that is not coincident with the first longitudinal axis; and (b) an ion outlet aperture; (2) providing voltages to electrodes of the ion transport apparatus that urge the ions to migrate towards the first longitudinal axis within the first electrode section; and (3) exhausting gas through a port that is offset from the ion outlet aperture.
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公开(公告)号：US12122805B2
公开(公告)日：2024-10-22
申请号：US17272614
申请日：2019-09-04
发明人： Carol V. Robinson , Idlir Liko , Hsin-Yung Yen , Kevin Pagel , Rainer Haag , Svenja Christina Ehrmann , Leonhard Hagen Urner
CPC分类号： C07K1/145 , G01N33/6848 , H01J49/0031 , H01J49/165
摘要： A method of detecting a protein by mass spectrometry comprises: providing a solution comprising a dendritic detergent and a protein; providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; vaporising the solution using the nanoelectrospray ionisation source; ionising the protein; resolving the ionised protein using the mass analyser; and detecting the resolved protein using the detector. A method of extracting a membrane protein from its native membrane comprises: providing a membrane protein in its native membrane; contacting the membrane protein with a dendritic detergent. Dendritic detergents for use in the methods are also provided.
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公开(公告)号：US20240347331A1
公开(公告)日：2024-10-17
申请号：US18682218
申请日：2022-08-10
发明人： Gordana IVOSEV , Nic BLOOMFIELD
IPC分类号： H01J49/00
CPC分类号： H01J49/0045
摘要： Methods for correlating a product ion in a mass spectrum to a precursor ion are disclosed herein, comprising determining a precursor ion ml z corresponding to the product ion as an m/z at which the product ion appears in a maximum amount of the series of mass spectra. Methods also can comprise obtaining a series of mass spectra for a sample across a mass range, each of the series of mass spectra having a precursor ion transmission window defined by a width (W) that overlaps with that of at least two of the series of mass spectra by a step size (S).
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公开(公告)号：US20240347328A1
公开(公告)日：2024-10-17
申请号：US18294930
申请日：2022-03-25
申请人： SHIMADZU CORPORATION
CPC分类号： H01J49/0031 , H01J49/005 , H01J49/0422
摘要： The method of operating a mass spectrometer includes: introducing precursor ions into a reaction chamber; generating radicals by generating plasma by supplying source gas and radio-frequency power to a radical generation chamber for a predetermined period by transmitting a predetermined control signal to a source gas supply part and a radio-frequency power supply part; generating product ions by introducing the radicals into the reaction chamber; measuring an intensity of light having a wavelength band including a wavelength of light emitted from the plasma inside the radical generation chamber; and determining and notifying an abnormality of the mass spectrometer on a basis of a fact that the intensity of the light exceeds a predetermined abnormality determination threshold value during a period other than the predetermined period.
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公开(公告)号：US20240347141A1
公开(公告)日：2024-10-17
申请号：US18689543
申请日：2022-09-08
CPC分类号： G16C20/20 , G16C20/70 , H01J49/0036
摘要： Methods and systems for identifying one or more analytes in a sample are provided. One aspect is a method of predicting an identity of analytes in an unknown sample, the method comprising accessing a database comprising a plurality of results from analyzing samples using mass spectrometry to identify analytes, the plurality of results including annotated ion fingerprints, training a machine learning model with the plurality of results, and applying the machine learning model to the unknown sample to predict an identity of one or more analytes in the unknown sample.
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公开(公告)号：US20240331993A1
公开(公告)日：2024-10-03
申请号：US18693037
申请日：2022-09-07
申请人： Scienta Omicron AB
发明人： Patrik KARLSSON
CPC分类号： H01J49/22 , H01J49/0004 , H01J49/025 , H01J49/44
摘要： A charged particle spectrometer is described, which comprises an imaging energy analyser and an electrostatic lens system, having a first deflector and optionally a second deflector operable to cause deflection of the charged particles in a coordinate direction a first and, if applicable, also a second time before the entrance into the imaging energy analyser. The spectrometer also comprises a control unit which is configured to control the nominal spatial position of the electrostatic lens system and to control the scanning in an angular mode of the spectrometer using a lens table. A computer program for controlling the control unit is also described.
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