公开(公告)号：WO2006090750A8

公开(公告)日：2008-01-10

申请号：PCT/JP2006303195

申请日：2006-02-22

Applicant: INST ANTIBODIES CO LTD ,  KUROSAWA YOSHIKAZU ,  AKAHORI YASUSHI ,  SUGIOKA ATSUSHI ,  HAYASHI NOBUHIRO ,  TAKASAKI AKIHIKO ,  SUZUKI KAZUHIRO ,  MORITA MIWA ,  KUROSAWA GENE ,  IBA YOSHITAKA ,  SUMITOMO MARIKO ,  TSUTSUMI SUSUMU ,  OGAWA KEIKO ,  MATSUDA KAZUKI ,  MURAMATSU CHIHO ,  TAKAHASHI NOBUHIRO ,  FUJIYAMA SARI ,  AZUMA MASACHIKA ,  UKAI YOSHINORI ,  MORISHITA KAZUHIRO

Inventor： KUROSAWA YOSHIKAZU ,  AKAHORI YASUSHI ,  SUGIOKA ATSUSHI ,  HAYASHI NOBUHIRO ,  TAKASAKI AKIHIKO ,  SUZUKI KAZUHIRO ,  MORITA MIWA ,  KUROSAWA GENE ,  IBA YOSHITAKA ,  SUMITOMO MARIKO ,  TSUTSUMI SUSUMU ,  OGAWA KEIKO ,  MATSUDA KAZUKI ,  MURAMATSU CHIHO ,  TAKAHASHI NOBUHIRO ,  FUJIYAMA SARI ,  AZUMA MASACHIKA ,  UKAI YOSHINORI ,  MORISHITA KAZUHIRO

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50

CPC classification number: C07K16/303 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2319/00 ,  G01N33/57426 ,  G01N33/57438

Abstract: It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, an ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.

Abstract translation: 旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。 通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，发挥ADCC活性。 基于这一发现，提供抗IgSF4抗体作为治疗癌症等的手段。

公开(公告)号：WO1990006998A1

公开(公告)日：1990-06-28

申请号：PCT/JP1989001275

申请日：1989-12-19

Applicant: MITSUI TOATSU CHEMICALS, INCORPORATED ,  EDUCATIONAL FOUNDATION FUJITA GAKUEN ,  KUROSAWA, Yoshikazu ,  ICHIHARA, Yoshikazu ,  AWAYA, Akira ,  ISHIZUKA, Yusaku

Inventor： MITSUI TOATSU CHEMICALS, INCORPORATED ,  EDUCATIONAL FOUNDATION FUJITA GAKUEN

IPC: C12N15/13

CPC classification number: C07K16/00

Abstract: The presence of DH genes belonging to any of the DH gene families DA, DK and DIR has been proved and DNA fragments containing at least one of these DH genes have been cloned. The DNA fragments are useful as a probe in the screening and identification of various DH genes and as a gene arrangement to be used in various genetic engineering techniques for the artificial preparation of immunoglobulins having various amino acids at specified sites. Furthermore the use of these DNA fragments makes it possible to detect and analyze rejoining parts of VHDHJH and utilize DNA fragments selected on the basis of the DNA sequences thus clarified as the tumor marker, thereby allowing the detection of tumor cells of the B-cell or T-cell type, or the diagnosis of lymphoid tumor, leukemia, etc.

公开(公告)号：WO1989003425A1

公开(公告)日：1989-04-20

申请号：PCT/JP1988001044

申请日：1988-10-14

Applicant: MITSUI TOATSU CHEMICALS, INCORPORATED ,  MITSUI PHARMACEUTICALS, INCORPORATED ,  EDUCATIONAL FOUNDATION FUJITA GAKUEN ,  KUROSAWA, Yoshikazu ,  AWAYA, Akira ,  ISHIZUKA, Yusaku

Inventor： MITSUI TOATSU CHEMICALS, INCORPORATED ,  MITSUI PHARMACEUTICALS, INCORPORATED ,  EDUCATIONAL FOUNDATION FUJITA GAKUEN

IPC: C12N15/00

CPC classification number: C12N15/85 ,  C07K16/00

Abstract: Specific DNA sequences such as sigma), sigma)3, sigma)1, sigma)2 and sigma)4 different from switch sequences conventionally known in subclass production of antibody are cloned, and the DNA sequences themselves and DNA sequences homologous therewith are revealed from the obtained clones. It is clarified by using the clones that SIGMA) gene having homology with sigma) and SIGMA) gene having homology with sigma) exist adjacent to each other in the region between Cmu and Cdelta (SIGMA region), and their functions in class switch are being demonstrated. The clones of the present invention enables specific control of production of a subclass of antibody against various type and kind of antigen.