公开(公告)号：WO2015103190A1

公开(公告)日：2015-07-09

申请号：PCT/US2014/072654

申请日：2014-12-30

Applicant: BASF SE ,  GEORGIA INSTITUTE OF TECHNOLOGY

Inventor： AUWETER, Helmut ,  XU, Wen ,  BEHRENS, Sven, Holger ,  SHITTA, Abiola

IPC: A01N25/04 ,  A01N25/28 ,  B01F17/00

CPC classification number: A01N25/28 ,  A01N25/04 ,  A01N37/40

Abstract: Disclosed are improved water in oil in water double emulsions that are suitable for use in combination with an active agent, such as a pesticide active ingredient, for extended release products. The double emulsions are prepared using suitable osmolytes such that the majority of the resulting emulsion droplets include a single aqueous core inside of the oil phase, which results in a more consistent and predictable release profile for the active ingredient. In many embodiments, the double emulsions may be prepared using colloidal particles as stabilizers, thus negating the need for the use of conventional emulsifiers, which reduces the potential toxicity of the double emulsion and results in a more environmentally friendly and acceptable commercial product. Additionally, in many embodiments the double emulsions are prepared such that they are encapsulated with a shell-impermeable polymer to improve encapsulation efficiency such that a greater percentage of the active agent remains in a desired location and does not "leak" into less desired portions of the emulsion. The encapsulation processes described herein result in the formation of a polymeric protective layer at both water/oil interfaces such that the two separate, distinct encapsulation layers are formed.

Abstract translation: 公开了适用于与活性剂如农药活性成分组合用于延长释放产物的改进的水包油双水乳液。 使用合适的渗透剂制备双重乳液，使得大部分所得的乳液液滴包含在油相内部的单一水性核心，这导致活性成分的更一致和可预测的释放曲线。 在许多实施方案中，双重乳液可以使用胶体颗粒作为稳定剂来制备，因此不需要使用常规的乳化剂，这降低了双重乳液的潜在毒性并导致更环保且可接受的市售产品。 此外，在许多实施方案中，制备双重乳液使得它们用不可渗透的聚合物包封以提高包封效率，使得较大百分比的活性剂保留在期望的位置，并且不会“泄漏”到较不期望的部分 乳液。 这里描述的包封方法导致在水/油界面处形成聚合物保护层，使得形成两个分离的不同的包封层。

公开(公告)号：WO2015103195A1

公开(公告)日：2015-07-09

申请号：PCT/US2014/072659

申请日：2014-12-30

Applicant: BASF SE ,  GEORGIA INSTITUTE OF TECHNOLOGY

Inventor： AUWETER, Helmut ,  SHITTA, Abiola ,  WANG, Hongzhi ,  BEHRENS, Sven Holger ,  XU, Wen

IPC: B01J13/16

CPC classification number: B01J13/16

Abstract: Disclosed are improved water in oil in water double emulsions that are suitable for use in combination with an active agent, such as a pesticide active ingredient, for extended release products. The double emulsions are prepared using suitable osmolytes such that the majority of the resulting emulsion droplets include a single aqueous core inside of the oil phase, which results in a more consistent and predictable release profile for the active ingredient. In many embodiments, the double emulsions may be prepared using colloidal particles as stabilizers, thus negating the need for the use of conventional emulsifiers, which reduces the potential toxicity of the double emulsion and results in a more environmentally friendly and acceptable commercial product. Additionally, in many embodiments the double emulsions are prepared such that they are encapsulated with a shell-impermeable polymer to improve encapsulation efficiency such that a greater percentage of the active agent remains in a desired location and does not "leak" into less desired portions of the emulsion. The encapsulation processes described herein result in the formation of a polymeric protective layer at both water/oil interfaces such that the two separate, distinct encapsulation layers are formed.

Abstract translation: 公开了适用于与活性剂如农药活性成分组合用于延长释放产物的改进的水包油双水乳液。 使用合适的渗透剂制备双重乳液，使得大部分所得的乳液液滴包含在油相内部的单一水性核心，这导致活性成分的更一致和可预测的释放曲线。 在许多实施方案中，双重乳液可以使用胶体颗粒作为稳定剂来制备，因此不需要使用常规的乳化剂，这降低了双重乳液的潜在毒性并导致更环保且可接受的市售产品。 此外，在许多实施方案中，制备双重乳液使得它们用不可渗透的聚合物包封以提高包封效率，使得较大百分比的活性剂保留在期望的位置并且不会“泄漏”到较不期望的部分 乳液。 这里描述的包封方法导致在水/油界面处形成聚合物保护层，使得形成两个分离的不同的包封层。