公开(公告)号：WO2023282771A1

公开(公告)日：2023-01-12

申请号：PCT/NZ2022/050092

申请日：2022-07-08

Applicant: COVID-19 VACCINE CORPORATION LIMITED

Inventor： FELDMAN, Robert Graham ,  HERBERT, Andrew Brian ,  HOLLINGS, Andrew James ,  MAZZOCCO, Giovanni ,  MYRONOV, Alexander ,  NIEMIEC, Iga ,  STĘPNIAK, Piotr ,  KOLBACHER, Oliver ,  SCHUBERT, Benjamin

IPC: C07K14/005 ,  C07K14/165 ,  A61P31/14 ,  A61K39/00 ,  A61K39/215 ,  C12N7/00

Abstract: The present disclosure relates to a multivalent vaccine composition characterised in that it elicits broad spectrum protection against at least one strain of coronavirus (such as a viral lineage, in particular SARS-Cov-2, more specifically selected from B.1.617. 2 [delta and/or kappa variants], B.1.1.7 and/or omicron), said vaccine comprising: a pool of T cell epitopes derived from at least one viral protein wherein the vaccine has a calculated world population HLA coverage of at least 95%, for example 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5%, 99%, 99.1%, 99.2%, 99.3%, 99.4%, 99.5%, 99.6%, 99.7%, 99.8%. The disclosure also relates to constructs disclosed herein, methods or preparing same and use in treatment including prophylaxis.