-
1.发明申请
公开(公告)号：WO2022125363A1
公开(公告)日：2022-06-16
申请号：PCT/US2021/061542
申请日：2021-12-02
发明人： ROOSA, John H. , GIANOTTI, III, Frank D. , O'CONNOR, Robert C. , SCHENCK, Luke Ryan , YUHAS, Matthew
摘要： Apparatus and method for collecting a dried pharmaceutical product from a product reservoir of a pharmaceutical drying device, such as a thin film evaporator, while the product reservoir remains under continuous vacuum pressure. The apparatus comprises a discharge chute, a vacuum supply control valve, a product inlet valve, a gas control valve, a collection control valve and one or more collection containers. The discharge chute comprises a substantially airtight internal chamber, a housing substantially surrounding the airtight internal chamber, a vacuum supply inlet that fluidly connects the airtight internal chamber of the discharge chute to a vacuum source, a solids inlet that fluidly connects the internal chamber to a product reservoir of the dryer, a gas inlet that fluidly connects the airtight internal chamber to a gas source, and a solids outlet that fluidly connects the airtight internal chamber to a collection container. The inlets and outlets are opened and closed by operation of flow control valves connected to those inlets and outlets in order to remove or admit gas to the discharge chute to effectively depressurize and re-pressurize the discharge chute, while moving dried pharmaceutical product out of the dryer and through the discharge chute. A flow diverter assembly directs "on-spec" material to a primary collection container and "off-spec" material to an auxiliary or "waste" collection container.
-
2.发明申请
公开(公告)号：WO2022125364A1
公开(公告)日：2022-06-16
申请号：PCT/US2021/061544
申请日：2021-12-02
发明人： ROOSA, John H. , D'ALESSANDRO, Alan S. , GIANOTTI, III, Frank D. , O'CONNOR, Robert C. , SCHENCK, Luke Ryan , STANOCH, Timothy , YUHAS, Matthew
摘要： A compact containment system comprises a mixing apparatus, a drying apparatus and a discharge apparatus. The mixing apparatus, which may be used to produce a slurry or solution mixture of solvent and dry powder during drug processing, comprises a dual compartment isolator for safely removing the dry powder from a dry powder container, a mixing vessel, and a negative cascading pressure controller. The drying apparatus comprises a drying unit, such as a thin film evaporator. The discharge apparatus comprises a discharge chute, a vacuum supply control valve, a product inlet valve, a gas control valve, a collection control valve and one or more collection containers. The discharge chute comprises a substantially airtight internal chamber, a housing substantially surrounding the airtight internal chamber, a vacuum supply inlet that fluidly connects the airtight internal chamber of the discharge chute to a vacuum source, a solids inlet that fluidly connects the internal chamber to a product reservoir of the dryer, a gas inlet that fluidly connects the airtight internal chamber to a gas source, and a solids outlet that fluidly connects the airtight internal chamber to a collection container. The inlets and outlets are opened and closed by operation of flow control valves connected to those inlets and outlets in order to remove or admit gas to the discharge chute to effectively depressurize and re-pressurize the discharge chute, while moving dried pharmaceutical product out of the dryer and through the discharge chute. A flow diverter assembly directs "on-spec" material to a primary collection container and "off-spec" material to an auxiliary or "waste" collection container.
-
搜索结果
2 条记录 (耗时 0.01 秒)
