公开(公告)号：WO2016187616A1

公开(公告)日：2016-11-24

申请号：PCT/US2016/033786

申请日：2016-05-23

Applicant: NOBLIS, INC.

Inventor： THOMAS, Sterling ,  DELLINGER, Nathan ,  IVANCICH, Mychal

IPC: G06F19/22

CPC classification number: H04L69/04 ,  G06F19/22 ,  H03M7/30 ,  H03M7/3088 ,  H03M7/3093 ,  H03M7/42 ,  H03M7/70 ,  H04L65/607

Abstract: Systems and methods for performing genomic information compression, transmission, and decompression are provided. A system for compression, transmission, and decompression of genomic information includes a first computer associated with a first index and a second computer associated with a second index, each index containing reference permutations of nucleic acid sequence portions, each permutation associated with a reference number. The first computer uses input genomic information and the first index to produce a compressed representation of the genomic information, and transmits the compressed representation to the second computer. The second computer uses the compressed representation and the second index to assemble a data representation of the genomic information. The compressed representation comprises references to permutations, indications of locations of each permutation in the input information, indications of variations to permutations, and/or indications of sequence length.

Abstract translation: 提供了用于执行基因组信息压缩，传输和解压缩的系统和方法。 用于基因组信息的压缩，传输和解压缩的系统包括与第一索引相关联的第一计算机和与第二索引相关联的第二计算机，每个索引包含核酸序列部分的参考排列，每个置换与参考号相关联。 第一计算机使用输入基因组信息和第一索引来产生基因组信息的压缩表示，并将压缩表示传送到第二计算机。 第二台计算机使用压缩表示和第二个索引来组合基因组信息的数据表示。 压缩表示包括对置换的引用，输入信息中每个排列的位置的指示，排列变化的指示和/或序列长度的指示。