公开(公告)号：WO2016186968A1

公开(公告)日：2016-11-24

申请号：PCT/US2016/032155

申请日：2016-05-12

Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： SHERMAN, Scott ,  FALK, Torsten ,  ESTEVEZ, Miguel

IPC: A01N33/02 ,  A61K31/135

CPC classification number: A61K31/135 ,  A61K31/166 ,  A61K31/198 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5415 ,  A61K31/551 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K2300/00

Abstract: This invention provides methods utilizing ketamine for the treatment of motor disorders and/or side effects associated with certain medications used in the treatment of motor disorders. For example, in some embodiments, methods are provided for treating side effects associated with the administration of levodopa to a subject having Parkinson's disease, by administering a dose of ketamine or a pharmaceutically acceptable salt thereof. In particular, the invention provides methods for reducing dyskinesia associated with motor disorder (e.g., Parkinson's disease) treatments, and effective doses of ketamine or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供利用氯胺酮治疗运动障碍和/或与用于治疗运动障碍的某些药物相关的副作用的方法。 例如，在一些实施方案中，提供了通过施用一定剂量的氯胺酮或其药学上可接受的盐来治疗与向患有帕金森病的受试者施用左旋多巴有关的副作用的方法。 特别地，本发明提供了减少与运动障碍（例如帕金森病）治疗相关的运动障碍的方法，以及有效剂量的氯胺酮或其药学上可接受的盐。