公开(公告)号：WO2023010074A1

公开(公告)日：2023-02-02

申请号：PCT/US2022/074252

申请日：2022-07-28

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： DE FIGEIREDO, Paul ,  SONG, Jim ,  FICHT, Tom ,  ALANIZ, Robert

IPC: A61K39/10 ,  A61K39/02 ,  A61P31/04

Abstract: The present disclosure provides pharmaceutical compositions comprising a live attenuated bacterial strain of Brucella melitensis, in particular a live attenuated bacterial strain of Brucella melitensis is Brucella melitensis 16M ∆vjbR (Bm∆vjbR). Methods of utilizing the live attenuated bacterial strain of Brucella melitensis for treatment of a patient are also provided, including wherein the patient is in need of treatment for cancer, an autoimmune disorder, and/or an inflammatory disorder.