公开(公告)号：WO2019068098A1

公开(公告)日：2019-04-04

申请号：PCT/US2018/053787

申请日：2018-10-01

Applicant: VANDERBILT UNIVERSITY

Inventor： DUVALL, Craig L. ,  KAVANAUGH, Taylor ,  DAILING, Eric ,  DOLLINGER, Bryan ,  DEJULIUS, Carlisle

IPC: A61K38/44 ,  A61K38/43 ,  A61K45/00 ,  A61P19/00

Abstract: Provided herein are a reactive oxygen species (ROS) scavenging composition, a method of forming a ROS scavenging composition, and a method of treating a subject having a (ROS) perpetuated disease. The ROS scavenging composition includes a co-polymer of a hydrophilic monomer and a grafting monomer, and a ROS scavenging compound grafted to the grafting monomer. The method of forming a ROS scavenging composition includes forming a co-polymer of a hydrophilic monomer and a grafting monomer, and grafting ROS scavenging compound onto the co-polymer. The method of treating a subject having a ROS perpetuated disease includes administering a therapeutically effective amount of an ROS scavenging composition comprising a co-polymer of a hydrophilic monomer and a grafting monomer, and a ROS scavenging compound grafted to the grafting monomer, to the subject in need thereof.