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公开(公告)号：WO2015057945A1
公开(公告)日：2015-04-23
申请号：PCT/US2014/060869
申请日：2014-10-16
Inventor： ZLOTNICK, Adam , LI, Lichun , TURNER, William Jr. , FRANCIS, Samson
IPC: A61K31/535 , A61K31/497 , C07D413/00
CPC classification number: A61K31/506 , C07D239/47 , C07D239/48
Abstract: Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.
Abstract translation: 公开了具有针对乙型肝炎病毒（HBV）感染的治疗作用的新型组装效应物化合物。 本文所述的组装效应分子可导致病毒组装有缺陷，也可能影响与慢性HBV感染有关的其他病毒活性。 还公开了合成所公开的化合物的方法，通过施用所公开的化合物治疗HBV的方法，以及这些化合物在制备针对HBV的药物中的用途。
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92.发明申请USE OF ACAMPROSATE TO MODULATE ERK 1-2 ACTIVATION IN ANIMAL MODELS FOR FXS AND ASD AND INDIVIDUALS DIAGNOSED WITH FXS AND ASD 审中-公开在FXS和ASD和用FXS和ASD诊断的个体的动物模型中使用抗氧化剂来调节ERK 1-2活化
公开(公告)号：WO2015057736A1
公开(公告)日：2015-04-23
申请号：PCT/US2014/060527
申请日：2014-10-14
Inventor： ERICKSON, Craig , LAHIRI, Debomoy
IPC: G01N33/53
CPC classification number: G01N33/573 , A61K31/16 , A61K31/185 , G01N2333/4709 , G01N2333/48 , G01N2333/91205 , G01N2500/20 , G01N2800/2814 , G01N2800/52
Abstract: Studies in mouse models of Fragile X and preliminary studies in human youth demonstrate that ERKl/2 is biomarker useful to monitoring the treatment of people diagnosed with ASD. Results reported herein demonstrate that acamprosate has the ability to reduce levels of ERKl/2 activation associated with many of the symptoms of ASD. Accordingly, in addition to its utility as a diagnostic marker for ASD ERKl/2 activation levels can be used to monitory patients treated with acamprosate.
Abstract translation: 对脆性X的小鼠模型的研究和人类青年的初步研究表明ERK1 / 2是监测诊断为ASD的人的治疗的生物标志物。 本文报道的结果表明，acamprosate具有降低与许多ASD症状相关的ERK1 / 2激活水平的能力。 因此，除了作为ASD的诊断标记物的作用之外，ERK1 / 2激活水平可用于用阿坎酸治疗的临床患者。
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93.发明申请
公开(公告)号：WO2015057471A2
公开(公告)日：2015-04-23
申请号：PCT/US2014/059811
申请日：2014-10-09
Inventor： EKBIA, Hamid, R. , GROGG, Pete
CPC classification number: A63F13/20 , A61B5/1128 , A61B5/16 , A61B5/4833 , A61B5/744 , A63F13/21 , G06F19/00 , G06Q50/22 , G06Q50/26
Abstract: In one illustrative embodiment, a tele-rehabilitation platform allows patients to play and interact with therapists, caregivers, and other patients. The platform includes a set of computer games, a therapist portal, and a knowledgebase for the storage and analysis of therapy outcomes for specific patients, conditions, and therapy regimes.
Abstract translation: 在一个说明性实施例中，远程康复平台允许患者与治疗师，照顾者和其他患者进行游戏并进行交互。 该平台包括一套计算机游戏，一个治疗师门户和一个知识库，用于存储和分析特定患者，病情和治疗方案的治疗结果。
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公开(公告)号：WO2015042332A2
公开(公告)日：2015-03-26
申请号：PCT/US2014/056430
申请日：2014-09-19
Inventor： IZADIAN, Afshin
IPC: H02J3/14
CPC classification number: H02M7/797 , H02J3/28 , H02J7/022 , H02M2007/2195 , H02M2007/4815 , Y02B70/1408 , Y02B70/1441
Abstract: A bidirectional AC-to-DC and DC-to-AC circuit includes a first inductor- capacitor (LC) circuit connected to an AC power source, a transistor synchronized with the AC power source signal, a second LC circuit electrically connected to the synchronized transistor and the first inductor-capacitor circuit, a high-frequency switching transistor electrically connected to the second inductor-capacitor circuit and a direct current (DC) load, and a controller connected to the high-frequency switching transistor. The controller identifies an error between a measured DC output signal and a predetermined DC output signal that is applied to the DC load, and adjusts a duty cycle of a pulse width modulation (PWM) switching signal for the high- frequency transistor to reduce the identified error.
Abstract translation: 双向AC-DC和DC-AC电路包括连接到AC电源的第一电感器 - 电容器（LC）电路，与AC电源信号同步的晶体管，电连接到同步的第二LC电路 晶体管和第一电感器 - 电容器电路，与第二电感器 - 电容器电路和直流（DC）负载电连接的高频开关晶体管，以及连接到高频开关晶体管的控制器。 控制器识别测量的直流输出信号和施加到直流负载的预定直流输出信号之间的误差，并调整用于高频晶体管的脉宽调制（PWM）切换信号的占空比，以减少所识别的 错误。
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95.发明申请COVALENTLY-GRAFTED POLYANILINE ON GRAPHENE OXIDE SHEETS AND ITS APPLICATION IN ELECTROCHEMICAL SUPERCAPACITORS 审中-公开在石墨烯氧化物片上共价共聚的聚苯胺及其在电化学超临界机中的应用
公开(公告)号：WO2015038570A2
公开(公告)日：2015-03-19
申请号：PCT/US2014/054887
申请日：2014-09-10
Inventor： XIE, Jian , LI, Zhe-Fei
CPC classification number: H01G11/36 , C08G73/0266 , C08G83/001 , H01G11/24 , H01G11/48 , H02J7/0068 , Y02E60/13 , Y02T10/7022
Abstract: A method for synthesizing a graphene-polyaniline hybrid composite, including oxidatively exfoliating natural graphite flakes to yield a graphene body, functionalizing the surface of a graphene substrate with aniline group, s wherein the surface of the graphene body is functionalized with aniline groups via a diazonium reaction, and polymerizing the aniline groups, wherein covalently-grafted polyaniline-graphene nanocomposites are formed by in- situ polymerization of aniline in the presence of aniline-functionalized graphene oxide, an oxidant, and an acid dopant.
Abstract translation: 一种用于合成石墨烯 - 聚苯胺混合复合材料的方法，包括氧化去角质天然石墨薄片以产生石墨烯体，用苯胺基官能化石墨烯基材表面，其中石墨烯体的表面经苯胺基团经由重氮 反应和聚合苯胺基团，其中共价接枝的聚苯胺 - 石墨烯纳米复合材料是在苯胺官能化的氧化石墨烯，氧化剂和酸掺杂剂的存在下苯胺的原位聚合形成的。
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公开(公告)号：WO2015013255A1
公开(公告)日：2015-01-29
申请号：PCT/US2014/047574
申请日：2014-07-22
Inventor： IZADIAN, Afshin
IPC: H02M7/00
Abstract: A bidirectional AC-to-DC and DC-to-AC circuit includes a first inductor-capacitor (LC) circuit connected to an AC power source, a transistor synchronized with the AC power source signal, a second LC circuit electrically connected to the synchronized transistor and the first inductor-capacitor circuit, a high-frequency switching transistor electrically connected to the second inductor-capacitor circuit and a direct current (DC) load, and a controller connected to the high-frequency switching transistor. The controller identifies an error between a measured DC output signal and a predetermined DC output signal that is applied to the DC load, and adjusts a duty cycle of a pulse width modulation (PWM) switching signal for the high-frequency transistor to reduce the identified error.
Abstract translation: 双向AC-DC和DC-AC电路包括连接到AC电源的第一电感器 - 电容器（LC）电路，与AC电源信号同步的晶体管，电连接到同步的第二LC电路 晶体管和第一电感器 - 电容器电路，与第二电感器 - 电容器电路和直流（DC）负载电连接的高频开关晶体管，以及连接到高频开关晶体管的控制器。 控制器识别测量的直流输出信号和施加到直流负载的预定直流输出信号之间的误差，并调整用于高频晶体管的脉宽调制（PWM）切换信号的占空比，以减少所识别的 错误。
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97.发明申请SYSTEM DESIGN AND METHOD FOR VERIFYING 3D DOSIMETRIC IMAGING OF CHARGED PARTICLES IN MEDIA 审中-公开用于验证媒体中充电颗粒的三维成像的系统设计和方法
公开(公告)号：WO2014179430A2
公开(公告)日：2014-11-06
申请号：PCT/US2014/036112
申请日：2014-04-30
Inventor： MOSKVIN, Vadim , STANTZ, Keith, Michael
CPC classification number: A61N5/1071 , A61B8/08 , A61B8/0833 , A61B8/483 , A61B2019/524 , A61N5/1031 , A61N5/1039 , A61N5/1075 , A61N2005/1034 , A61N2005/1076 , A61N2005/1087
Abstract: A method of verifying therapeutic proton beam delivery accuracy by ultrasound tomographic imaging to map three dimensional (3D) proton dose through the detection of ionizing radiation induced thermo-acoustic signal from the proton beam.
Abstract translation: 一种通过超声层析成像来验证治疗质子束传递精度的方法，通过检测离子辐射引起的来自质子束的热声信号来映射三维（3D）质子剂量。
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公开(公告)号：WO2014149973A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/021682
申请日：2014-03-07
Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION , YOKOTA, Hiroki , HAMAMURA, Kazunori , ZHANG, Ping
Inventor： YOKOTA, Hiroki , HAMAMURA, Kazunori , ZHANG, Ping
IPC: A61K31/155
CPC classification number: A61K31/155 , A61K31/15 , A61K31/47
Abstract: Described herein are methods for treating bone diseases or defects. The methods include administering to a host animal therapeutically effective amounts of one or more compounds that are selective inhibitors of dephosphorylation of eIF2α.
Abstract translation: 本文描述的是治疗骨疾病或缺陷的方法。 所述方法包括向宿主动物施用治疗有效量的一种或多种作为eIF2α脱磷酸化选择性抑制剂的化合物。
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公开(公告)号：WO2014127171A1
公开(公告)日：2014-08-21
申请号：PCT/US2014/016332
申请日：2014-02-13
Inventor： FLOOD, Amar, H. , LEE, Semin , CHEN, Chun-hsing , MCDONALD, Kevin
CPC classification number: C07C255/47 , C07D213/57 , C07D249/04 , C07F7/0818 , C07F7/1852
Abstract: The present disclosure concerns synthesis and anion binding features of polycyanostilbene macrocycles (structurally represented).
Abstract translation: 本公开内容涉及聚氰胂基大环化合物的合成和阴离子结合特征（结构上表示）。
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公开(公告)号：WO2013138430A1
公开(公告)日：2013-09-19
申请号：PCT/US2013/030748
申请日：2013-03-13
Inventor： KELLEY, Mark, R. , FISHEL, Melissa, L. , CARDOSO, Angelo, A.
IPC: A61K31/122
CPC classification number: C07D295/192 , A61K31/16 , A61K31/164 , A61K31/201 , A61K31/381 , A61K31/45 , A61K31/475 , A61K31/495 , A61K31/519 , A61K31/5375 , A61K31/573 , A61K31/704 , A61K45/06 , C07C49/563 , C07C59/90 , C07C235/78 , C07D211/40 , A61K2300/00
Abstract: Compounds, and methods and uses of compounds, and pharmaceutical compositions thereof, are described herein for treating leukemia. In particular, compounds, and methods and uses of compounds, and pharmaceutical compositions thereof, are described herein for treating acute lymphoblastic leukemia (ALL) in its various forms.
Abstract translation: 化合物，化合物的方法和用途及其药物组合物在本文中描述用于治疗白血病。 特别地，本文描述了化合物，化合物的方法和用途及其药物组合物，用于治疗其各种形式的急性淋巴细胞性白血病（ALL）。
