公开(公告)号：WO2011083391A2

公开(公告)日：2011-07-14

申请号：PCT/IB2010056071

申请日：2010-12-24

Applicant: PFIZER ,  GREEN STEPHANIE JANET ,  GUALBERTO ANTONIO

Inventor： GREEN STEPHANIE JANET ,  GUALBERTO ANTONIO

IPC: G01N33/74

CPC classification number: G01N33/74 ,  G01N2333/4745 ,  G01N2333/62 ,  G01N2333/65 ,  G01N2333/71 ,  G01N2800/52

Abstract: The present invention relates to use of free IGF-1 and the ratio of insulin/IGFBP in the blood as biomarkers for IGF-1 R antagonist therapy for cancer and to method for treating cancer with an IGF-1 R therapy in patients selected based on such biomarkers.

Abstract translation: 本发明涉及使用游离IGF-1和血液中胰岛素/ IGFBP的比例作为IGF-1R拮抗剂治疗癌症的生物标志物和用IGF-1R治疗癌症的方法在基于 这样的生物标志物。