公开(公告)号：WO1994009792A1

公开(公告)日：1994-05-11

申请号：PCT/US1993010183

申请日：1993-10-25

Applicant: UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER ,  GREEN, Michael, R. ,  ZAPP, Maria, L. ,  STERN, Seth

Inventor： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER

IPC: A61K31/70

CPC classification number: A61K31/70

Abstract: Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule which binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are the 2-deoxystreptamine (2-DOS) aminoglycosides. Disclosed herein are members of the 2-DOS class that are useful for the inhibition of binding of an RNA to a trans-activating protein.

Abstract translation: 公开了抑制配体与RNA的结合的方法，该抑制是由与RNA结合的小的有机分子介导的，从而抑制配体结合。 优选的一类小有机分子是2-脱氧链霉胺（2-DOS）氨基糖苷类。 本文公开了可用于抑制RNA与反式激活蛋白结合的2-DOS类的成员。

公开(公告)号：WO2011011172A1

公开(公告)日：2011-01-27

申请号：PCT/US2010/040490

申请日：2010-06-29

Applicant: INTEGENX, INC. ,  STERN, Seth ,  BOGDAN, Greg

Inventor： STERN, Seth ,  BOGDAN, Greg

IPC: C12M1/34

CPC classification number: B01L3/502738 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/025 ,  B01L2300/1822 ,  B01L2400/0481

Abstract: The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The design of the cartridges, microchips, and pneumatic manifolds can allow for the use of magnetic forces to capture magnetic beads in a chamber formed between the microchip and the cartridge or a chamber within the microchip. The devices of the invention can be used for mRNA amplification and purification.

Abstract translation: 本发明提供用于将微芯片连接到墨盒和气动歧管的装置和方法。 墨盒，微芯片和气动歧管的设计可以允许使用磁力来捕获形成在微芯片和墨盒之间的腔室中的磁珠或微芯片内的腔室。 本发明的装置可用于mRNA的扩增和纯化。

公开(公告)号：WO2003042677A1

公开(公告)日：2003-05-22

申请号：PCT/US2002/036685

申请日：2002-11-13

Applicant: CALIPER TECHNOLOGIES CORP. ,  BROOKS, Carlton, F. ,  JENSEN, Morten, Juel ,  STERN, Seth

Inventor： BROOKS, Carlton, F. ,  JENSEN, Morten, Juel ,  STERN, Seth

IPC: G01N27/02

CPC classification number: B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00873 ,  B01J2219/0093 ,  B01J2219/0095 ,  B01J2219/00952 ,  B01J2219/00961 ,  B01L3/5027 ,  B01L7/52 ,  B01L2200/10 ,  B01L2200/147 ,  B01L2300/1827 ,  B01L2300/185 ,  B01L2400/0418 ,  G01N27/44791

Abstract: Methods and systems for effecting a parameter and detecting a parameter using two electric signals are described.

Abstract translation: 描述了使用两个电信号实现参数和检测参数的方法和系统。