公开(公告)号：WO2022240721A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/028277

申请日：2022-05-09

Applicant: ENTRADA THERAPEUTICS, INC.

Inventor： QIAN, Ziqing ,  SETHURAMAN, Natarajan ,  KIERBAHDI, Mah ,  LIU, Haoming ,  SHEN, Xiulong ,  LI, Xiang

IPC: A61K47/64 ,  A61P37/02 ,  C07K7/64 ,  C12N15/113 ,  A61K47/645 ,  C12N2310/11 ,  C12N2310/3233 ,  C12N2310/3513 ,  C12N2320/33

Abstract: Compounds that include a cyclic cell penetrating peptide and a therapeutic moiety modulates Interferon Regulatory Factor – 5 (IRF-5) activity in an immune cell. The therapeutic moiety is a therapeutic protein, a small molecule, or an antisense compound. Methods include administering the compound to cells or subjects to modulate IRF-5 activity. Methods include treating diseases associated with IRF-5 using the compounds.