公开(公告)号：WO2011057239A3

公开(公告)日：2011-06-30

申请号：PCT/US2010055953

申请日：2010-11-09

Applicant: ABBOTT LAB ,  HOSSLER PATRICK ,  CORREIA IVAN R

Inventor： HOSSLER PATRICK ,  CORREIA IVAN R

IPC: C12P21/02 ,  G01N33/50 ,  G01N33/68

CPC classification number: G01N33/68 ,  G01N33/5005 ,  G01N33/5023 ,  G01N33/56966

Abstract: The instant invention relates to the field of protein production, and in particular is relates to compositions and processes for improving the production levels of recombinant proteins expressed in host cells.

Abstract translation: 本发明涉及蛋白质生产领域，具体涉及用于提高在宿主细胞中表达的重组蛋白质的生产水平的组合物和方法。

公开(公告)号：WO2010093800A3

公开(公告)日：2011-05-12

申请号：PCT/US2010023910

申请日：2010-02-11

Applicant: ABBOTT LAB ,  TONER JOHN L ,  BURKE SANDRA E ,  CROMACK KEITH R ,  OEPEN RANDOLF VON

Inventor： TONER JOHN L ,  BURKE SANDRA E ,  CROMACK KEITH R ,  OEPEN RANDOLF VON

IPC: A61L29/16 ,  A61L31/16

CPC classification number: A61L31/16 ,  A61F2/91 ,  A61F2/958 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61F2310/0097 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/606 ,  A61M25/10 ,  A61M2025/105

Abstract: Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.

Abstract translation: 公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。 本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。 本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。 本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。

公开(公告)号：WO2011014659A3

公开(公告)日：2011-04-21

申请号：PCT/US2010043716

申请日：2010-07-29

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  LIU JUNJIAN ,  IBRAGHIMOV ALEXANDER

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  IBRAGHIMOV ALEXANDER

IPC: C12P21/08

CPC classification number: C07K16/468 ,  C07K16/2803 ,  C07K16/2851 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92 ,  G01N33/6854

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：WO2010123838A3

公开(公告)日：2011-03-03

申请号：PCT/US2010031660

申请日：2010-04-20

Applicant: ABBOTT LAB ,  PEDDI SRIDHAR ,  PATEL MEENA V ,  ROHDE JEFFREY J

Inventor： PEDDI SRIDHAR ,  PATEL MEENA V ,  ROHDE JEFFREY J

IPC: C07C261/04 ,  A61K31/26 ,  A61P3/10 ,  A61P25/00 ,  C07C257/14

CPC classification number: A61K31/26 ,  C07C257/14 ,  C07C257/16 ,  C07C261/04 ,  C07C311/46 ,  C07C317/30 ,  C07C327/42 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/18 ,  C07C2602/42 ,  C07C2602/44 ,  C07C2603/74 ,  C07C2603/97 ,  C07D207/277 ,  C07D211/14 ,  C07D213/24 ,  C07D213/26 ,  C07D213/74 ,  C07D231/12 ,  C07D239/42 ,  C07D257/04 ,  C07D261/08 ,  C07D277/42 ,  C07D295/14 ,  C07D307/46 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: The present invention relates to inhibitors of 11- ß-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

Abstract translation: 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征，中枢神经系统疾病和疾病和病症中的用途 这与过量的糖皮质激素有关。

公开(公告)号：WO2010036998A3

公开(公告)日：2011-03-03

申请号：PCT/US2009058553

申请日：2009-09-28

Applicant: ABBOTT LAB ,  SCHRIMPF MICHAEL R ,  LEE CHIH-HUNG ,  LI TAO ,  GFESSER GREGORY A ,  MORTELL KATHLEEN H ,  FAGHIH RAMIN ,  NERSESIAN DIANA L ,  SIPPY KEVIN B ,  BUNNELLE WILLIAM H ,  SCANIO MARC ,  SHI LEI ,  GOPALAKRISHNAN MURALI ,  DONNELLY-ROBERTS DIANA ,  HU MIN

Inventor： SCHRIMPF MICHAEL R ,  LEE CHIH-HUNG ,  LI TAO ,  GFESSER GREGORY A ,  MORTELL KATHLEEN H ,  FAGHIH RAMIN ,  NERSESIAN DIANA L ,  SIPPY KEVIN B ,  BUNNELLE WILLIAM H ,  SCANIO MARC ,  SHI LEI ,  GOPALAKRISHNAN MURALI ,  DONNELLY-ROBERTS DIANA ,  HU MIN

IPC: C07D487/18 ,  A61K31/33 ,  A61P25/00

CPC classification number: G01N33/5058 ,  C07D471/18 ,  C07D487/10 ,  C07D487/18 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/30

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

公开(公告)号：WO2011012314A2

公开(公告)日：2011-02-03

申请号：PCT/EP2010004678

申请日：2010-07-30

Applicant: ABBOTT LAB VASCULAR ENTPR LTD ,  GRANDT AXEL ,  JEFFREY ANDREW

Inventor： GRANDT AXEL ,  JEFFREY ANDREW

IPC: A61L29/04 ,  A61L29/12

CPC classification number: A61L29/126 ,  A61L29/18

Abstract: The present invention refers to medical devices comprising a non-metallic micro tube containing FRP (fiber reinforced polymer), especially to respective tubings, used for constructing catheters like balloon dilation catheters, stent delivery catheters, guiding catheters and diagnostic catheters.

Abstract translation: 本发明涉及包括用于构造导管如球囊扩张导管，支架输送导管，引导导管和诊断导管的FRP（纤维增强聚合物）的非金属微管，特别是用于相应管的医疗装置。

公开(公告)号：WO2010051318A9

公开(公告)日：2010-12-09

申请号：PCT/US2009062411

申请日：2009-10-28

Applicant: ABBOTT LAB ,  SEMIZAROV DIMITRI ,  LU XIN ,  ZHANG KE ,  LESNIEWSKI RICK R

Inventor： SEMIZAROV DIMITRI ,  LU XIN ,  ZHANG KE ,  LESNIEWSKI RICK R

CPC classification number: G06F19/34 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  G06F19/12 ,  G06F19/18 ,  G06F19/24 ,  G06F19/28

公开(公告)号：WO2010033543A3

公开(公告)日：2010-11-18

申请号：PCT/US2009057088

申请日：2009-09-16

Applicant: ABBOTT LAB ,  CARROLL WILLIAM A ,  DART MICHAEL J ,  FROST JENNIFER M ,  LATSHAW STEVEN P ,  KOLASA TEODOZYI ,  LI TONGMEI ,  PEDDI SRIDHAR ,  LIU BO ,  PEREZ-MEDRANO ARTURO ,  PATEL MEENA ,  WANG XUEQING ,  NELSON DEREK W

Inventor： CARROLL WILLIAM A ,  DART MICHAEL J ,  FROST JENNIFER M ,  LATSHAW STEVEN P ,  KOLASA TEODOZYI ,  LI TONGMEI ,  PEDDI SRIDHAR ,  LIU BO ,  PEREZ-MEDRANO ARTURO ,  PATEL MEENA ,  WANG XUEQING ,  NELSON DEREK W

IPC: C07D231/40 ,  A61K31/4155 ,  A61K31/433 ,  A61P29/00 ,  C07D285/135 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

CPC classification number: C07D405/12 ,  C07D231/40 ,  C07D285/135 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）的大麻素受体配体，其中A1，A5，Rx，X4和z如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2010039809A3

公开(公告)日：2010-08-05

申请号：PCT/US2009058992

申请日：2009-09-30

Applicant: ABBOTT LAB ,  ABRAVAYA KLARA ,  ERICKSON BRIAN J ,  HUANG SHIHAI X ,  MAK WAI-BING X ,  SALITURO JOHN A ,  TANG NING

Inventor： ABRAVAYA KLARA ,  ERICKSON BRIAN J ,  HUANG SHIHAI X ,  MAK WAI-BING X ,  SALITURO JOHN A ,  TANG NING

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12Q1/6886 ,  C12Q1/708 ,  C12Q2600/112 ,  C12Q2600/16

Abstract: The present invention relates to primers, probes, primer sets, primer and probe sets, methods and kits for detecting human papillomaviruses, human beta globin sequences and human papillomaviruses and human beta globin sequences in a test sample.

Abstract translation: 本发明涉及测试样品中的引物，探针，引物组，引物和探针组，用于检测人乳头状瘤病毒，人β球蛋白序列和人乳头状瘤病毒和人β珠蛋白序列的方法和试剂盒。

公开(公告)号：WO2010075199A2

公开(公告)日：2010-07-01

申请号：PCT/US2009068651

申请日：2009-12-18

Applicant: ABBOTT LAB ,  SAGE RUSSELL L

Inventor： SAGE RUSSELL L

IPC: C12M3/00

CPC classification number: C12N15/1013 ,  B01L3/502 ,  B01L3/5082 ,  B01L3/563 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0638

Abstract: A reaction vessel (RV) with a bottom drain opening and valve that can be actuated to open or close by applying a pressure differential. A support for RVs includes passages through which a vacuum may be drawn to selectively apply the pressure differential.

Abstract translation: 具有底部排放开口和阀的反应容器（RV），其可通过施加压力差而被致动以打开或关闭。 RV的支撑件包括可以抽出真空以选择性地施加压力差的通道。