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    CLEANING OF A FLUID PATH SYSTEM FOR HYPERPOLARIZATION OF A PHARMACEUTICAL PRODUCT
    21.
    发明申请
    CLEANING OF A FLUID PATH SYSTEM FOR HYPERPOLARIZATION OF A PHARMACEUTICAL PRODUCT 审中-公开

    公开(公告)号：WO2020178310A1

    公开(公告)日：2020-09-10

    申请号：PCT/EP2020/055639

    申请日：2020-03-04

    Applicant: DANMARKS TEKNISKE UNIVERSITET

    Inventor： ARDENKJÆR-LARSEN, Jan

    IPC: G01R33/28 ,  G01R33/30 ,  G01R33/31

    Abstract: The present disclosure relates to a method for cleaning a reusable fluid path system for hyperpolarization of a pharmaceutical product, said reusable fluid path system being continuously at least partly contained by a polarizer; the method comprising the steps of a) providing the polarizer with an inlet tube having a first inlet tube end for fluid contact with a fluid vessel and a second inlet tube end configured for fluid contact with a vial, for holding the pharmaceutical product during hyperpolarization; b) providing the polarizer with an outlet tube having a first outlet tube end configured for receiving the vial and a second outlet tube end for connecting to a receiving vessel; c) sealing the second inlet tube end with the first outlet tube end; d) fluidly connecting a medium vessel to the first inlet tube end; e) fluidly connecting a collector vessel to the second outlet tube end; f) cleaning the reusable fluid path system by transferring a cleaning medium from the medium vessel into the reusable fluid path system; g) ejecting the cleaning medium from the reusable fluid path system into a collector vessel; and h) drying the reusable fluid path system.

    AUTOMATED DETECTION OF RECEIVE COIL LOCATION
    22.
    发明申请
    AUTOMATED DETECTION OF RECEIVE COIL LOCATION 审中-公开

    公开(公告)号：WO2020144300A1

    公开(公告)日：2020-07-16

    申请号：PCT/EP2020/050471

    申请日：2020-01-10

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： VERNICKEL, Peter ,  LEUSSLER, Christoph, Günther ,  LIPS, Oliver ,  SCHMALE, Ingo ,  FINDEKLEE, Christian

    IPC: G01R33/28 ,  G01R33/34 ,  G01R33/36 ,  G01R33/54 ,  A61B5/055 ,  G01R33/341

    Abstract: The invention provides for a magnetic resonance imaging system (100, 300). The magnetic resonance imaging system comprises: a subject support (120) configured for moving a subject between a loading position (121) and an imaging position (200); a receive magnetic resonance imaging coil (114) configured for being placed on the subject; and a light detection system (115) comprising at least one ambient light sensor for measuring light data (144). The light detection system is any one of the following: mounted to the main magnet such that the light data is measured from the imaging zone and mounted to the receive magnetic resonance imaging coil. The execution of the machine executable (140) instructions by a processor (130) cause the processor to: move (500) the subject support from the loading position to the imaging position; acquire (502) the light data using the at least one ambient light sensor when the subject support is in the imaging position; determine (504) if the receive magnetic resonance imaging coil is positioned for acquiring magnetic resonance imaging data using the light data; and provide (506) a signal (146) if the receive magnetic resonance imaging coil is positioned for acquiring the magnetic resonance imaging data.

    A TRANSMISSION SYSTEM FOR TRANSMITTING OUTPUT UNIT SIGNALS AND CONTROL SIGNALS TO AT LEAST ONE INTERFACE CONNECTED WITH OPTICAL FIBER
    23.
    发明申请
    A TRANSMISSION SYSTEM FOR TRANSMITTING OUTPUT UNIT SIGNALS AND CONTROL SIGNALS TO AT LEAST ONE INTERFACE CONNECTED WITH OPTICAL FIBER 审中-公开

    公开(公告)号：WO2020128113A3

    公开(公告)日：2020-06-25

    申请号：PCT/EP2020/060606

    申请日：2020-04-15

    Applicant: NEURO DEVICE GROUP S.A.

    Inventor： SOLUCH, Pawel Sebastian ,  ORZECHOWSKI, Mateusz Marek ,  WROTKOWSKI, Krzysztof ,  OBREBSKI, Wojciech ,  ROGOWSKI, Pawel

    IPC: G01R33/28 ,  H04Q11/00

    Abstract: Described is a transmission system (100 to 1000) including a data output unit (110, 210, 810b), for instance a camera operating within MRI environment. In an embodiment, a control transfer unit (812b to 812d) may manage the operation of the data output unit (110, 210, 810b), wherein the control transfer unit (812b to 812d) may be preferably located closely to data output unit (110, 210, 810b), e.g. mounted in vicinity of MRI device (192) or within a radius of less than 5 meters or less than 3 meters from the MRI device (192). The control transfer unit (812b to 812d) may have one connection or multiple connections to at least one additional secondary control unit, e.g. to sending and receiving units (250, 250b1, 250b2). Each of the sending and receiving units (250, 250b1, 250b2) and/or the control transfer unit (812b to 812d) may be capable of receiving the data from the data output unit (110, 210, 810b), send control data/signals and/or acknowledge control data/signals issued by other sending and receiving units (110, 210, 810b) and/or by the control transfer unit (812b to 812d). Each pair of optically coupled units may be connected via single optical fiber connection.

    SYSTEMS AND METHOD FOR GENERATION OF HYPERPOLARIZED MATERIALS
    24.
    发明申请
    SYSTEMS AND METHOD FOR GENERATION OF HYPERPOLARIZED MATERIALS 审中-公开

    公开(公告)号：WO2020104854A3

    公开(公告)日：2020-05-28

    申请号：PCT/IB2019/001316

    申请日：2019-11-20

    Applicant: NVISION IMAGING TECHNOLOGIES GMBH

    Inventor： SCHWARTZ, llai ,  EICHHORN, Tim, Rolf ,  VASSILIOU, Christophoros ,  KEIM, Michael

    IPC: G01R33/28 ,  A61K49/06

    Abstract: Systems and methods for generating hyperpolarized target materials are disclosed. The disclosed systems and methods can include hyperpolarizing a compound then transferring polarization to a target material. The compound can be selected to have nuclear spins. The compound can be further selected to have electron spins that, when exposed to certain electromagnetic radiation, exceed a predetermined level of polarization. The compound can be exposed to such electromagnetic radiation, optically hyperpolarizing the electron spins of the compound. Polarization can then be transferred from the electron spins of the compound to nuclear spins of the compound, at least in part by exposing the compound to a magnetic field. The compound can be exposed to the target material before or after pulverizing the compound to increase the surface area of the compound, thereby facilitating transfer of polarization from the compound to the target material.

    A SERIES OF CATALYSTS FOR THE HYPERPOLARISATION OF SUBSTRATES
    25.
    发明申请
    A SERIES OF CATALYSTS FOR THE HYPERPOLARISATION OF SUBSTRATES 审中-公开

    公开(公告)号：WO2020095047A2

    公开(公告)日：2020-05-14

    申请号：PCT/GB2019/053146

    申请日：2019-11-06

    Applicant: UNIVERSITY OF YORK

    Inventor： ROY, Soumya Singha ,  IALI, Wissam ,  TICKNER, Ben ,  DUCKETT, Simon Benedict

    IPC: G01R33/28 ,  G01N24/08 ,  G01N33/58

    Abstract: There is described a method for the preparation of a hyperpolarised agent, wherein said agent comprises at least one –N - , –O - or –S - moiety (optionally protonated) and a secondary binding site; said method comprising: (i) preparing a fluid containing a polarisation transfer precatalyst and parahydrogen; (ii) introducing a co-ligand to interact with the transfer precatalyst to form a polarisation transfer catalyst; (iii) applying a magnetic field or radio frequency excitation to (ii), such that hyperpolarisation is transferred from parahydrogen to a target molecule; (iv) introducing a target molecule containing at least at least one –N - , –O - or –S - moiety, in conjunction with a secondary binding to form a hyperpolarised agent; wherein the co-ligand is selected from the group consisting of one or more of a sulfoxide, a thioester, a phosphine, an amine, CO, an isonitrile and a nitrogen heterocycle.

    SUPRALEITENDES MAGNETSPULENSYSTEM
    28.
    发明申请
    SUPRALEITENDES MAGNETSPULENSYSTEM 审中-公开

    公开(公告)号：WO2020011625A1

    公开(公告)日：2020-01-16

    申请号：PCT/EP2019/067890

    申请日：2019-07-03

    Applicant: BRUKER BIOSPIN GMBH

    Inventor： FRANTZ, Wolfgang ,  CAMINADA, Rafael ,  NEUBERTH, Gerald

    IPC: H01F6/02 ,  G01R33/28 ,  H01F6/06

    Abstract: Die Erfindung betrifft ein supraleitendes Magnetspulensystem mit einer ersten elektrischen Masche (M1) und einer zweiten elektrischen Masche (M2), die in Serie miteinander verschaltet sind, wobei die erste elektrische Masche (M1) in einem ersten Pfad einen HTS(high temperature superconductor)-Spulenabschnitt (A0) und in Serie dazu einen ersten Hauptspulenabschnitt (A1) und in einem zweiten Pfad ein Quenchschutzelement (Q1) umfasst, das die Serienschaltung von HTS-Spulenabschnitt (A0) und erstem Hauptspulenabschnitt (A1) überbrückt. Der erste Hauptspulenabschnitt (A1) umfasst einen Leiter mit supraleitenden Filamenten in einer Matrix. Die zweite elektrische Masche (M2) umfasst einen Nachbar-Hauptspulenabschnitt (A3) mit einen Leiter mit supraleitenden Filamenten in einer Matrix. Der Nachbar-Hauptspulenabschnitt (A3) ist derjenige Hauptspulenabschnitt einer anderen als der ersten elektrischen Masche, der in radialer Richtung nach außen dem ersten Hauptspulenabschnitt (A1) der ersten elektrischen Masche am nächsten liegt. Das Magnetspulensystem ist dadurch gekennzeichnet, dass im Quenchfall die Leiter der Hauptspulenabschnitte (A1, A3, A4) jeweils einen spezifischen Leistungseintrag (LT/2ϖ) 2 * 1/ρ M erzeugen, wobei der spezifische Leistungseintrag des Leiters des ersten Hauptspulenabschnitts (A1) der ersten elektrischen Masche (M1) höher ist als der spezifische Leistungseintrag des Leiters des Nachbar-Hauptspulenabschnitts (A3) der zweiten elektrischen Masche (M2). Somit kann unter Verwendung von HTS-Supraleitermaterial ein Magnetspulensystem bereitgestellt werden, mit dem besonders hohe Feldstärken erzeugt werden können und/oder das eine geringe Baugröße aufweist.

    SYSTÈME DE DÉTECTION PORTABLE COMPRENANT DES CAPTEURS MAGNÉTOSTATIQUES
    29.
    发明申请
    SYSTÈME DE DÉTECTION PORTABLE COMPRENANT DES CAPTEURS MAGNÉTOSTATIQUES 审中-公开

    公开(公告)号：WO2020002680A1

    公开(公告)日：2020-01-02

    申请号：PCT/EP2019/067475

    申请日：2019-06-28

    Applicant: MANNESCHI, Alessandro

    Inventor： MANNESCHI, Alessandro

    IPC: G01V3/08 ,  G01V3/165 ,  G01V3/10 ,  G01R33/28

    Abstract: L'invention concerne un système de détection d'un objet cible comprenant : - un premier détecteur (10) comprenant au moins un premier capteur (5) magnétique et au moins un émetteur (8), - un deuxième détecteur (20) distinct du premier détecteur (10) et comprenant au moins un deuxième capteur (5) magnétique et au moins un émetteur (8), et - au moins une unité de traitement (6) configurée pour recevoir les signaux indicatifs d'une intensité d'un champ magnétique détecté par le premier capteur (5) magnétique et/ou le deuxième capteur (5) magnétique, - une interface de communication (7) configurée pour transmettre le signal généré par le premier et/ou le deuxième capteur (5) magnétique à l'unité de traitement (6), et l'unité de traitement (6) étant configurée pour envoyer des instructions de génération d'une alarme à l'émetteur (8) du premier détecteur (10) et/ou du deuxième détecteur (20).

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