公开(公告)号：WO2023019767A1

公开(公告)日：2023-02-23

申请号：PCT/CN2021/130052

申请日：2021-11-11

Applicant: INTEL CORPORATION ,  ZHANG, Ming ,  FAN, Yuehong ,  WEI, Peng ,  WANG, Chuanlou ,  MONGIA, Rajiv ,  ZHANG, Guocheng ,  BU, Yingqiong ,  WONDIMU, Berhanu ,  TAN, Guixiang ,  QUE, Xiang ,  JIANG, Qing ,  YU, Liu ,  CHU, Wei-Ming ,  ZHANG, Chen ,  ZHOU, Hao ,  QI, Feng ,  BIBER, Catharina ,  KULKARNI, Devdatta P. ,  LI, Xiang ,  ZHANG, Yechi

Inventor： ZHANG, Ming ,  FAN, Yuehong ,  WEI, Peng ,  WANG, Chuanlou ,  MONGIA, Rajiv ,  ZHANG, Guocheng ,  BU, Yingqiong ,  WONDIMU, Berhanu ,  TAN, Guixiang ,  QUE, Xiang ,  JIANG, Qing ,  YU, Liu ,  CHU, Wei-Ming ,  ZHANG, Chen ,  ZHOU, Hao ,  QI, Feng ,  BIBER, Catharina ,  KULKARNI, Devdatta P. ,  LI, Xiang ,  ZHANG, Yechi

IPC: H05K7/20

Abstract: Heat pipes and vapor chambers that are components of a DIMM cooling assembly are described.

公开(公告)号：WO2022213118A1

公开(公告)日：2022-10-06

申请号：PCT/US2022/071489

申请日：2022-03-31

Applicant: ENTRADA THERAPEUTICS, INC. ,  DOUGHERTY, Patrick ,  KHEIRABADI, Mahboubeh ,  LI, Xiang ,  QIAN, Ziqing

Inventor： DOUGHERTY, Patrick ,  KHEIRABADI, Mahboubeh ,  LI, Xiang ,  QIAN, Ziqing

IPC: C07K7/64 ,  C07K19/00 ,  C12N15/113 ,  A01K2217/075 ,  A01K2227/105 ,  A61K47/6455 ,  C12N15/111 ,  C12N15/87 ,  C12N15/907 ,  C12N2310/11 ,  C12N2310/3145 ,  C12N2310/3233 ,  C12N2310/3513 ,  C12N2320/32

Abstract: The present disclosure is directed to cell penetrating peptides, including cyclic cell penetrating peptides with high cytosolic delivery efficiency and reduced toxicity that are able to effectively deliver cargo inside a cell to treat a variety of conditions and diseases.

公开(公告)号：WO2021155581A1

公开(公告)日：2021-08-12

申请号：PCT/CN2020/074516

申请日：2020-02-07

Applicant: COTHERA BIOSCIENCE, INC. ,  LI, Xiang ,  CHEN, Yiyou

Inventor： LI, Xiang ,  CHEN, Yiyou

IPC: C12N15/19 ,  C12Q1/68 ,  A61P35/00

Abstract: Provided are combination therapies and secondary biomarkers for treating MYCC-associated diffuse large B-cell lymphoma (DLBCL) with YM155-based therapies, and related kits, compositions, and methods of use thereof.

公开(公告)号：WO2017058831A1

公开(公告)日：2017-04-06

申请号：PCT/US2016/054040

申请日：2016-09-28

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  BRUNETTE, Steven Richard ,  CSENGERY, Johanna ,  HUGHES, Robert Owen ,  LI, Xiang ,  SIBLEY, Robert ,  TURNER, Michael Robert ,  XIONG, Zhaoming

Inventor： BRUNETTE, Steven Richard ,  CSENGERY, Johanna ,  HUGHES, Robert Owen ,  LI, Xiang ,  SIBLEY, Robert ,  TURNER, Michael Robert ,  XIONG, Zhaoming

IPC: C07D475/10 ,  A61K31/519 ,  A61P43/00 ,  A61P3/10 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02

CPC classification number: C07D475/10

Abstract: The present invention encompasses compounds of formula (I) wherein the variables are defined herein which are suitable for the modulation of RORγ and the treatment of diseases related to the modulation of RORγ. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract translation: 本发明包括式（I）化合物，其中本文所定义的变量适用于调节RORγ和治疗与RORγ调节有关的疾病。 本发明还包括制备式（I）化合物和含有它们的药物制剂的方法。

公开(公告)号：WO2015054243A1

公开(公告)日：2015-04-16

申请号：PCT/US2014/059485

申请日：2014-10-07

Applicant: ZHOU, Qifa ,  LI, Xiang ,  VAN DAM, Jacques ,  SHUNG, K. Kirk ,  CUMMINS, Thomas ,  CHEN, Zhongping

Inventor： ZHOU, Qifa ,  LI, Xiang ,  SHUNG, K. Kirk ,  CUMMINS, Thomas ,  CHEN, Zhongping

IPC: A61B1/05 ,  A61B8/12 ,  A61B10/04 ,  A61B6/00 ,  A61M25/10

CPC classification number: A61B8/4416 ,  A61B1/00082 ,  A61B1/0016 ,  A61B1/018 ,  A61B1/041 ,  A61B1/043 ,  A61B1/05 ,  A61B1/2736 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0095 ,  A61B5/6853 ,  A61B5/687 ,  A61B5/6871 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4461 ,  A61B10/0233 ,  A61B10/0283 ,  A61B10/04

Abstract: A multimodality imaging system including ultrasound, optical coherence tomography (OCT), photoacoustic (PA) imaging, florescence imaging and endoscopic catheter for imaging inside the gastrointestinal tract with real-time automatic image co-registration capability, including: an ultrasound subsystem for imaging; an optical coherence tomography (OCT) subsystem for imaging, a PA microscopy or tomography subsystem for imaging and a florescence imaging subsystem for imaging. An invasive interventional imaging device is included with an instrumentality to take a tissue biopsy from a location visible on the ultrasound subsystem for imaging, on the optical coherence tomography (OCT) subsystem for imaging, photoacoustic (PA) subsystem for imaging and florescence subsystem for imaging. The instrumentality takes a tissue biopsy from a visible location simultaneously with the visualization of the tissue about to be biopsied so that the tissue biopsy location is visualized before, during and after the biopsy.

Abstract translation: 包括：成像超声子系统，包括超声波，光学相干断层扫描（OCT），光声（PA）成像，荧光成像和内窥镜导管，用于在胃肠道内成像，具有实时自动图像共同配准能力。 用于成像的光学相干断层摄影（OCT）子系统，用于成像的PA显微镜或层析成像子系统和用于成像的荧光成像子系统。 入侵介入成像装置包括一个手段，从超声子系统上可见的位置进行组织活检，用于成像，用于成像的光学相干断层扫描（OCT）子系统，用于成像的光声（PA）子系统和用于成像的成像和荧光子系统 。 手术从可见的位置进行组织活检，同时可以对待组织的组织的可视化进行活检，以便组织活检位置在活检之前，期间和之后可视化。

公开(公告)号：WO2003081391A3

公开(公告)日：2003-10-02

申请号：PCT/US2003/008628

申请日：2003-03-19

Applicant: MAPINFO CORPORATION ,  MOON, George, C. ,  MATTHEW, Tweedie ,  DOVE, John ,  DEWALD, Edward ,  LI, Xiang ,  PETRONIS, Scott ,  BERRILL, Arthur, R. ,  LEA, Tony

Inventor： MOON, George, C. ,  MATTHEW, Tweedie ,  DOVE, John ,  DEWALD, Edward ,  LI, Xiang ,  PETRONIS, Scott ,  BERRILL, Arthur, R. ,  LEA, Tony

IPC: H04Q7/20

Abstract: The disclosed method and system provide extensible or stand-alone location enabled services at granularity down to a stand-alone service. The various interfaces are preferably specified via DTD or schemas for communication based on XML (400). This collection of services enables management of mobile device locations information (420), and real-time services. Mobile device location is integrated with other location sensitive data, such as maps (465) or demographics of a particular region or even the location of businesses and consumers to enable a richer service offering for customers of wireless carriers (405) and service providers. Examples of such services include obtaining routes to a destination (470); providing a geocode corresponding to an address (450); providing an address corresponding to a geocode (440); providing maps as image files encompassing specified geocodes, locations, or addresses and the like. Additional services may be added to the disclosed system and method seamlessly due to the use of extensible interfaces.

公开(公告)号：WO2023028734A1

公开(公告)日：2023-03-09

申请号：PCT/CN2021/115241

申请日：2021-08-30

Applicant: QUALCOMM INCORPORATED ,  LI, Xiang ,  LOUKAS JR., Serafim ,  RAMASWAMY, Gurunath ,  ZHANG, Hua ,  DING, Yong

Inventor： LI, Xiang ,  LOUKAS JR., Serafim ,  RAMASWAMY, Gurunath ,  ZHANG, Hua ,  DING, Yong

IPC: G06F21/57 ,  G06F21/64

Abstract: Various embodiments include methods and devices for generating and verifying a software image with a safety feature. Embodiments may include generating a safety feature from a first software image, and generating a second software image including the safety feature. Embodiments may include, retrieving a first safety feature from a software image with the first safety feature, calculating a second safety feature based on information relating to the software image with the first safety feature, comparing the first safety feature and the second safety feature, and verifying safety of the software image with the first safety feature in response to the first safety feature matching with the second safety feature. The methods and devices may be implemented in compliance with functional safety standards, such as ISO 26262 functional safety standards and, in compliance with Automotive Safety Integrity Level (ASIL) requirements, such as ASIL-D and/or ASIL QM requirements.

公开(公告)号：WO2022267065A1

公开(公告)日：2022-12-29

申请号：PCT/CN2021/102560

申请日：2021-06-25

Applicant: INTEL CORPORATION ,  LIU, Min ,  FRANKO, Jaemon ,  JIN, Xia ,  LI, Xiang ,  LIU, Jiaqi ,  SURYA, Krishna

Inventor： LIU, Min ,  FRANKO, Jaemon ,  JIN, Xia ,  LI, Xiang ,  LIU, Jiaqi ,  SURYA, Krishna

IPC: G06F9/30

Abstract: A processing device (30, 710) for reducing scan traffic is provided. The processing device (30, 710) comprises one or more interfaces (32, 718) configured to transmit information to at least one register access interface (759, 761) and processing circuitry (34) configured to control the one or more interfaces. Further, the processing circuitry (34) is configured to obtain register parameters of at least one functional unit (760, 762) of a processing unit (750) and to generate an improved bulk register comprising the register parameters of the at least one functional unit.

公开(公告)号：WO2022066502A1

公开(公告)日：2022-03-31

申请号：PCT/US2021/050657

申请日：2021-09-16

Applicant: LI, Xiang

Inventor： LI, Xiang

IPC: A61K31/4965 ,  A61K31/417 ,  C12Q1/68 ,  G01N33/574 ,  A61P35/00 ,  A61K31/4164 ,  G01N33/53 ,  C12N15/11

Abstract: Provided is the use of NOTCH as a biomarker for the efficacy of YM155 monobromide in cancer therapy, and related kits, compositions, and methods for diagnosing and treating cancer in a subject in need thereof.

公开(公告)号：WO2021155580A1

公开(公告)日：2021-08-12

申请号：PCT/CN2020/074515

申请日：2020-02-07

Applicant: COTHERA BIOSCIENCE, INC. ,  LI, Xiang ,  JIANG, Chun ,  CHEN, Yiyou

Inventor： LI, Xiang ,  JIANG, Chun ,  CHEN, Yiyou

IPC: A61P35/00 ,  A61K31/497 ,  A61K45/06

Abstract: Provided are methods of using an anti-cancer agent's cell cycle-related, cell-killing activity to identify it as an effective combination with YM155 monobromide for treating MYC-associated cancers, and related kits, compositions, methods of screening, and methods for treating cancer in a subject in need thereof.