公开(公告)号：WO99005200A1

公开(公告)日：1999-02-04

申请号：PCT/GB1998/002231

申请日：1998-07-24

IPC分类号： C07B61/00 ,  C07F9/09 ,  C07F9/113 ,  C07F9/12 ,  C08G65/32 ,  C08G65/322 ,  C08G65/335

CPC分类号： C08G65/3353 ,  C07F9/091 ,  C08G65/322

摘要： The invention provides an improved process for the synthesis of compounds carrying at least one phosphate group, especially polyalkylene glycol phosphate compounds, said process comprising the steps of: (a) reacting a compound containing at least one primary alcohol moiety with a diaryl- or diaralkyl- halophosphate whereby to form the corresponding diaryl- or diaralkyl-phosphate ester; (b) reductively cleaving the resulting product; and (c) if desired, repeating steps (a) and (b) with the product of step (b) whereby to produce a compound carrying two or more phosphate groups. Advantages of the process in accordance with the invention are that this avoids the production of by-products and results in products which are low in impurities. Also provided are novel diaryl- and diaralkyl-phosphate ester compounds, in particular polyethylene glycol diphenylphosphate ester and derivatives thereof.

摘要翻译： 本发明提供了一种用于合成携带至少一种磷酸酯基团的化合物，特别是聚亚烷基二醇磷酸酯化合物的改进方法，所述方法包括以下步骤：（a）使含有至少一个伯醇部分的化合物与二芳基或二烷基 - 卤代磷酸盐，由此形成相应的二芳基 - 或二烷基 - 磷酸酯; （b）还原性地切割所得产品; 和（c）如果需要，用步骤（b）的产物重复步骤（a）和（b），由此产生携带两个或更多个磷酸酯基团的化合物。 根据本发明的方法的优点在于，这避免了副产物的生产并导致杂质低的产物。 还提供了新的二芳基 - 和二烷基 - 磷酸酯化合物，特别是聚乙二醇二苯基磷酸酯及其衍生物。