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公开(公告)号:WO2023017165A1
公开(公告)日:2023-02-16
申请号:PCT/EP2022/072702
申请日:2022-08-12
Applicant: BASF SE
Inventor: SCHULTZE, Hergen , HAJNAL, David , WEISS, Horst , JELICH, Holger Kai Peter , NIEMEIER, Lukas , DIAZ, Jorge Samuel
IPC: G05B19/418 , G05B13/04
Abstract: The present disclosure generally relates to a computer-implemented method (100) for generating operation conditions usable to control a manufacturing or development process, the method comprising the steps of: a) providing (110), via an input channel, a set of operation conditions, a set of associated measured objective properties that represent characteristics of a system, and a set of parameterized system models; b) performing (120), by a processor, a parameter identification process for each parameterized system model of the set of parameterized system models; c) determining (130), by the processor, if at least one parameterized system model of the set of parameterized system models yields a prediction quality above a predefined value, if it is determined that the at least one parameterized system model of the set of parameterized system models yields the prediction quality above the predefined value, identifying (140) the at least one parameterized system model with the highest prediction quality d) performing (150), by a processor, a multi-objective optimizing process on the identified at least one parameterized system model; e) providing (160), via an output channel, a control file usable for the manufacturing or the development process including operation conditions obtained by the multi-objective optimizing process on the identified system model; and if it is determined that the at least one parameterized system model of the set of parameterized system models yields the prediction quality below the predefined value, identifying (170) the at least one parameterized system model with the highest prediction quality; d1) determining (180), specifically calculating, an experimental design usable to control the manufacturing or the development process based on the prediction quality of the identified system model; e1) providing (190), via an output channel, the determined experimental design.
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52.
公开(公告)号:WO2023006460A1
公开(公告)日:2023-02-02
申请号:PCT/EP2022/069947
申请日:2022-07-15
Applicant: ABB SCHWEIZ AG
Inventor: GUTERMUTH, Georg , FRANKE, Rüdiger , BISKOPING, Matthias , LENDERS, Felix , GRINDLER, Clemens
Abstract: The invention provides an electrolyzer plant comprising a plurality of electrolyzer modules and a method for controlling operation of said electrolyzer plant. The electrolyzer plant comprises a system comprising a processing unit and configured to determine, for each of the plurality of electrolyzer modules, an electrolyzer module set point at which the electrolyzer module is to be operated, and control operation of each of the plurality of electrolyzer modules at the respective electrolyzer module set point. The determining comprises inputting data representative of operation characteristics of each of the plurality of electrolyzer modules into the processing unit and the processing unit performing an optimization procedure that outputs the electrolyzer module set points, the optimization procedure comprising an optimization for one or more of overall electrolyzer plant efficiency, overall plant lifetime, lifetime of each of the electrolyzer modules, operational safety, and maintenance patterns.
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公开(公告)号:WO2023002029A1
公开(公告)日:2023-01-26
申请号:PCT/EP2022/070653
申请日:2022-07-22
Applicant: BASF SE
Inventor: KRAUTKRAEMER, Christian
Abstract: The present invention refers to a closing device (100) comprising a closing element (1), a sealing element (20) and aclosing cap (30),wherein the closing element (1) comprises a fluid channel (2) having an input opening (3) and an output opening (4),wherein the fluid channel (2) is aligned along a closing axis (50),wherein the closing element (1) comprises a first fastener,wherein the first fastener (5) is configured and arranged in such a manner, that the closing element (1) is connectable at least form-fitted or force-fitted with a neck of a container, such that a filling material inside the container is guidable into the fluid channel (2) through the input opening (3),wherein the closing element (1) comprises a receiving arrangement (6) for receiving the sealing element (20),wherein the receiving arrangement (6) comprises a latching nose (7) projecting to the closing axis (50) or a latching recess directed away from the closing axis (50) for at least form-fit or force-fit connecting of the closing element (1) with the sealing element (20),wherein the closing element and the sealing element are configured in such a manner, that in a sealed state of the closing device (100) the sealing element (20) is engaged with the receiving arrangement (6) and the sealing element (20) seals the fluid channel (2) at least liquid-tight,and in an unsealed state of the closing device (100), the sealing element (20) is disengaged with the receiving arrangement (6),wherein the closing element (1) and the closing cap (30) are configured and arranged in such a manner, that the closing device (100) can be brought in a closed state, in which the closing cap (30) closes output opening (4), and can be brought in an opened state, in which the output opening (4) is released,characterized in that,a sealing protrusion (8) is located at least at one of the receiving arrangement (6), and the sealing element (20),wherein the sealing protrusion (8) is arranged at a sealing area between the receiving arrangement (6) and the sealing element (20), such that in a sealed state of the closing device the sealing protrusion (8) abuts on the sealing area between the receiving arrangement (6) and the sealing element (20) for at least liquid-tightly sealing the fluid channel.
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公开(公告)号:WO2023285461A1
公开(公告)日:2023-01-19
申请号:PCT/EP2022/069465
申请日:2022-07-12
Applicant: LEIBNIZ-INSTITUT FÜR VIROLOGIE
Inventor: BREMER, Jan Peter , KNORR, Marius Sebastian , ALTFELD-BUNDERS, Madeleine , ALTFELD, Markus
Abstract: A method (100) for quantifying and/or analyzing organoids from a digital image (2) of a biological sample (1), comprising the steps of: mapping (110), by a first neural network (3a) and/or a first section (4a) of one neural network (4), the image (2) to bounding boxes (5) that enclose instances of organoids; mapping (120), by a second neural network (3b) and/or a second section (4b) of the one neural network (4), for each bounding box (5), the content of this bounding box (5), and/or a work product of the first neural network (3a) and/or first section (4a) that relates to this bounding box (5), to one or more masks (6) that identify the image pixels belonging to each instance (7) of an organoid; and evaluating (130), from the one or more masks (6), a number (7a) of instances (7) of organoids in the image, and/or at least one physical and/or biological property (7b) of at least one instance (7) of an organoid.
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55.
公开(公告)号:WO2023285349A1
公开(公告)日:2023-01-19
申请号:PCT/EP2022/069258
申请日:2022-07-11
Applicant: 2N PHARMA APS
Inventor: THIEMERMANN, Christoph , BRUUN-NYZELL, Preben , MOHAMMAD, Shireen , SKØTTRUP MØTKHOLT, Anne
IPC: A61K31/551 , A61P25/28 , A61P43/00 , C07D417/14 , C07D417/04 , C07D493/08
Abstract: The present invention relates to Carnitine-Palmitoyl-Transferase-1 (CPT-1) inhibitors for use in a method of preventing or treating sepsis in a mammalian subject. The invention also relates to pharmaceutical compositions comprising a Carnitine-Palmitoyl-Transferase-1 (CPT-1) inhibitor for said use.
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公开(公告)号:WO2023285198A1
公开(公告)日:2023-01-19
申请号:PCT/EP2022/068503
申请日:2022-07-05
Applicant: OMYA INTERNATIONAL AG
Inventor: FTOUNI, Jamal , THARUN, Jose , BRUIJNINCX, Peter C.A.
Abstract: A process for preparing an alcohol by a Guerbet self-condensation reaction in the gas phase. The process comprises the steps of: a) providing a primary or secondary alcohol, wherein the primary or secondary alcohol has at least one p-hydrogen; b) providing a surface-reacted calcium carbonate, wherein the surface-reacted calcium carbonate is a reaction product of ground natural calcium carbonate (GNCC) or precipitated calcium carbonate (PCC) with carbon dioxide and one or more H3O+ ion donors and wherein the carbon dioxide is formed in situ by the H3O+ ion donors treatment and/or is supplied from an external source, and wherein the surface-reacted calcium carbonate has a specific surface area of at least 15 m2/g, measured using nitrogen and the BET method according to ISO 9277:2010; c) vaporizing the alcohol; d) reacting the vaporized alcohol in the presence of the surface-reacted calcium carbonate as a catalyst.
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公开(公告)号:WO2023274597A1
公开(公告)日:2023-01-05
申请号:PCT/EP2022/059275
申请日:2022-04-07
Applicant: SEMSYSCO GMBH
Inventor: HOFER, Georg , GLEISSNER, Andreas
IPC: H01L21/67 , H01L21/6708 , H01L21/67253
Abstract: The disclosure relates to a system (17) for a surface treatment of a substrate (1) with a liquid, comprising: a first substrate holder (18), a second substrate holder (19), a liquid dispensing unit (21), a treatment chamber (20), and control unit (22), wherein the first substrate holder (18) is configured to hold the substrate (1), wherein the first substrate holder (18) is moveable in the treatment chamber (20) and configured to hand the substrate (1) over to the second substrate holder (19), wherein the second substrate holder (19) is rotatable and configured to hold the substrate (1) during a rotation of the substrate (1) in and relative to the treatment chamber (20), wherein the liquid dispensing unit (21) is moveable relative to the second substrate holder (19) and configured to dispense the liquid onto the substrate (1), and wherein the control unit (22) is configured to control a rotational speed of the substrate (1), a position of the liquid dispensing unit (21) and/or a dispense rate of the liquid. Further, the disclosure also relates to a method (100) for a surface treatment of a substrate (1) with a liquid, and to a computer program element for a system (17) for a surface treatment of a substrate (1) with a liquid.
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公开(公告)号:WO2022268887A1
公开(公告)日:2022-12-29
申请号:PCT/EP2022/067030
申请日:2022-06-22
Applicant: FORMYCON AG
Inventor: SIGL, Rainer , SCHOTT, Katharina Maria
IPC: A61K39/395 , A61K47/26 , A61K9/00 , A61K9/08 , A61K47/12 , A61K47/18 , A61P35/00 , C07K16/28 , A61K39/00 , A61K2039/505 , A61K39/39591 , A61K47/183 , A61K9/0019 , C07K16/2818 , C07K2317/24 , C07K2317/76 , C07K2317/94
Abstract: The present invention relates to pharmaceutical compositions of an anti-PD1 antibody comprising acitrate buffer, one or more amino acids other than histidine and a surfactant.
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公开(公告)号:WO2022268861A1
公开(公告)日:2022-12-29
申请号:PCT/EP2022/066970
申请日:2022-06-22
Applicant: VEGA GRIESHABER KG
Inventor: KASPAR, Stefan , BURGERT, Florian , LANGENSIEPEN, Christian
IPC: G05B19/042 , G06F21/35 , G05B19/0425 , G05B19/0428 , G06F2221/2103 , H04L63/0838
Abstract: Die Erfindung betrifft eine Bedien- und Anzeigeeinheit (110) zur Identifizierung eines Feldgeräts (100), aufweisend: ein internes Register (102), eingerichtet zum Speichern einer Identifikation des Feldgeräts (100); und eine Darstellungseinheit (112, 114), eingerichtet zu einer kodierten Darstellung der Identifikation, wobei die kodierte Darstellung der Identifikation ein Identifizierungsmerkmal umfasst.
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公开(公告)号:WO2022268294A1
公开(公告)日:2022-12-29
申请号:PCT/EP2021/066943
申请日:2021-06-22
Applicant: ABB SCHWEIZ AG
Inventor: VANCU, Florian , FUEGLISTER, Markus
Abstract: The invention relates to an inrush current limiter circuit (102, 104, 105) for a rectifier (100), wherein the inrush current limiter circuit provides a flow of a current between a rectifying part (101) of the rectifier (100) and a filter capacitance (109), comprising a power stage (105); wherein the power stage (105) comprises a power stage resistor (108) and a power stage transistor (107) parallel to the power stage resistor (108), wherein the power stage resistor (108) is configured to conduct an amount of the current in dependence on the state of the power stage transistor (107), and wherein the power stage transistor (107) is configured to conduct an amount of the current in dependence on a charging of a gate capacitance of the power stage transistor (107).
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