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公开(公告)号：WO2021041759A1
公开(公告)日：2021-03-04
申请号：PCT/US2020/048324
申请日：2020-08-28
Inventor： MOHAMADZADEH, Mansour
Abstract: The present disclosure is directed to modified Propionibacterium and methods of use (e.g., to produce vitamin B12). Methods of increasing vitamin B12 production in a bacterium comprising a vitamin B12 riboswitch are also contemplated.
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公开(公告)号：WO2021035169A1
公开(公告)日：2021-02-25
申请号：PCT/US2020/047472
申请日：2020-08-21
Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION
Inventor： FERRARO, Christopher Charles , PARIS, Jerry M. , VILLATORO, Juan Carlos , TOWNSEND, Timothy G.
Abstract: Various examples are provided related to manufacturing portland cement with thermal plasma. In one example, a method includes providing a raw kiln feed to a plasma arc gasification kiln; and forming clinker by heating the raw kiln feed in the plasma arc gasification kiln. The raw kiln feed can be heated with a plasma plume supplied with argon gas to a temperature in a range from about 1800°C to about 3000°C. In another example, a system includes a kiln feed system and a plasma arc gasification kiln that receives raw kiln feed from the kiln feed system and heats the raw kiln feed with a plasma plume to form clinker. The system can include a clinker processing system configured to process the formed clinker to produce portland cement.
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53.发明申请
公开(公告)号：WO2021016316A1
公开(公告)日：2021-01-28
申请号：PCT/US2020/043011
申请日：2020-07-22
Inventor： GOLDE, Todd E. , RAN, Yong , GOODWIN, Marshall , CRUZ, Pedro , LEVITES, Yona
IPC: C07K14/525 , C12N15/85 , A61K38/17 , G01N33/53 , C07K14/47
Abstract: Provided herein are compositions and methods for the stable production of bioactive small peptides of interest through delivery to target cells based on the fusion of small peptides of interest to a collagen domain of a C1qTNF protein to produce a novel scaffold protein capable of multimerization. Advantageously, the fusion proteins, compositions and methods of the present disclosure meet existing needs in the art by providing for higher stable expression and longer stability of intracellular and secretable peptides of interest. Additionally, the fusion proteins, compositions and methods of the present disclosure provide for improved binding affinity of expressed receptor peptides with ligand binding partners in the target cell. Further provided herein are polynucleotide constructs encoding the described fusion proteins and recombinant adeno-associated viral particles comprising these polynucleotides. Also provided herein are pharmaceutical compositions and nanoparticles that comprise the described fusion proteins. Further provided herein are methods of treating a subject by administering the described fusion proteins, rAAV particles, compositions and/or nanoparticles.
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公开(公告)号：WO2021007110A1
公开(公告)日：2021-01-14
申请号：PCT/US2020/040725
申请日：2020-07-02
Inventor： RANUM, Laura , NGUYEN, Lien
Abstract: Aspects of the disclosure relate to compositions and methods for the diagnosis and/or treatment of certain neurodegenerative diseases, for example those diseases associated with repeat-associated non-ATG (RAN) translation proteins, such as Alzheimer's disease (AD). In some embodiments, the disclosure relates to identifying a subject having a RAN protein- associated disease by detecting expression or activity of repeat-associated non-ATG (RAN) translation proteins ( e.g ., RAN proteins). In some embodiments, the disclosure relates to methods of treating a RAN protein-associated disease by administering to a subject in need thereof an agent that reduces expression or activity of RAN proteins.
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公开(公告)号：WO2020243659A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/035441
申请日：2020-05-29
Inventor： RIVKEES, Scott, A. , SRIVASTAVA, Arun
IPC: C07K16/28 , C12N15/864
Abstract: Disclosed herein are compositions and methods for continuous AAV-based delivery of blocking anti-TSHR antibodies to a subject having a thyroid disease. The present disclosure is based, at least in part, on the realization that blocking anti-TSHR antibodies may be delivered in a continuous manner using rAAV, e.g., rAAVS, to effectively block the stimulating effects of TSAbs or TSH on TSHR, thereby blocking or reducing the synthesis of thyroid hormone. By blocking or reducing the synthesis of thyroid hormone, the presently described methods and compositions for rAAV-based delivery of blocking anti-TSHR antibodies (e.g., K1-70) may be used to treat thyroid diseases, including Graves' disease, Graves' orbitopathy, and thyroid cancer without the requirement of repeated administrations.
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Patent Agency Ranking
公开(公告)号：WO2020214399A2
公开(公告)日：2020-10-22
申请号：PCT/US2020/025739
申请日：2020-03-30
Inventor： WAGENER, Kenneth, B. , PRIBYL, Julia, Grace , BELL, Michael, H.
IPC: C08F4/60
Abstract: A method of carrying out a metathesis reaction includes the combination of at least one alkene or non conjugated diene with a Ruthenium-based catalyst with an cyclic(alkyl)(amino)carbene ligand to form a reaction mixture, heating the reaction mixture to a temperature of 100°C or greater in the absence of a solvent in bulk conditions, and mechanically stirring the reaction mixture. The reaction can be an ADMET, ROMP, a metathesis ring-closure or an olefin exchange reaction.
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公开(公告)号：WO2020186198A1
公开(公告)日：2020-09-17
申请号：PCT/US2020/022713
申请日：2020-03-13
Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION
Inventor： LAMPOTANG, Samsun , LIZDAS, David Erik
Abstract: Disclosed are various embodiments for a guidance and tracking system that facilitate templated and targeted biopsy and/or treatment. A guidance and tracking system may include a catheter having a six-degree-of-freedom magnetic tracking sensor, where the catheter can be positioned and anchored in an organ or a natural passage of an organ such as the urethral passage in the prostate of a patient. Using tracking sensors, a computing device may be employed to track a location and orientation of an organ and medical instruments during a treatment or diagnostic procedure. The computing device may determine a position and orientation of the medical instrument relative to the organ of interest. A graphical user interface including real, three-dimensional objects to overlay and adjust biopsy templates onto a real three-dimensional organ or lesion that is manually reconstructed prior to the biopsy procedure. A simulator or simulator mode can be provided for training.
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公开(公告)号：WO2020185775A2
公开(公告)日：2020-09-17
申请号：PCT/US2020/021886
申请日：2020-03-10
Inventor： CRECY, Valerie, Anne De , HUTINET, Geoffrey, Jean
IPC: C12N7/00
Abstract: The present disclosure is directed to materials and methods for reducing heterologous DNA damage in bacteria (i.e., induce resistance to host restriction enzymes) by modifying the heterologous DNA to include one or more deazapurine bases.
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公开(公告)号：WO2020180960A1
公开(公告)日：2020-09-10
申请号：PCT/US2020/020947
申请日：2020-03-04
IPC: A01H6/28 , A61K31/352 , C12M1/34
Abstract: In one aspect, the disclosure relates to substituted axially-chiral cannabinol analogs, methods of making same, pharmaceutical compositions comprising same, and methods of treating pain using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：WO2020180928A1
公开(公告)日：2020-09-10
申请号：PCT/US2020/020888
申请日：2020-03-04
Inventor： DYKA, Frank, M. , HAUSWIRTH, William, W.
Abstract: The present disclosure provides short enhanced human opsin promoters for rod-specific expression that satisfy a need in the art for promoters that are able to control transgene expression both efficiently and selectively in rod cells, with little to no off-target expression in other photoreceptor cells. The disclosure provides vector constructs comprising transgenes operably controlled by this enhanced human opsin promoter that may be delivered and targeted with high specificity to rod cells. The disclosure also provides compositions comprising these vector constructs and methods for administration of these compositions to subjects in need thereof.
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