PURIFIED INTERLEUKIN-15/Fc FUSION PROTEIN AND PREPARATION THEREOF
    53.
    发明申请
    PURIFIED INTERLEUKIN-15/Fc FUSION PROTEIN AND PREPARATION THEREOF 审中-公开
    纯化的INTERLEUKIN-15 / Fc融合蛋白及其制备

    公开(公告)号:WO2005100394A2

    公开(公告)日:2005-10-27

    申请号:PCT/EP2005/003887

    申请日:2005-04-13

    CPC classification number: C07K14/5443

    Abstract: The present invention relates to a process for purifying an interleukin-15/Fc fusion protein from a composi­tion, which process comprises a) applying the composition to an affinity chromatography column and eluting a first IL-15/Fc eluate from the column and b) applying the eluate of step a) to an ion exchange chromatography column and eluting a second IL-15/Fc eluate from the column; and to a purified interleukin­-15/Fc fusion protein and a composition, in particular a pharmaceutical composition, comprising such a fusion protein.

    Abstract translation: 本发明涉及从组合物中纯化白细胞介素-15 / Fc融合蛋白的方法,该方法包括:a)将组合物施用于亲和色谱柱并从柱中洗脱第一IL-15 / Fc洗脱液,和b) 将步骤a)的洗脱液施用到离子交换层析柱并从柱中洗脱第二种IL-15 / Fc洗脱液; 和纯化的白细胞介素-15 / Fc融合蛋白和包含这种融合蛋白的组合物,特别是药物组合物。

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