公开(公告)号：WO2019073374A1

公开(公告)日：2019-04-18

申请号：PCT/IB2018/057804

申请日：2018-10-09

Applicant: AMO DEVELOPMENT, LLC

Inventor： MALEK TABRIZI, Alireza ,  FU, Hong ,  HILL, James E. ,  WITOWSKI, Zenon

IPC: A61F9/008

Abstract: An ophthalmic surgical laser system includes: a laser that produces a pulsed laser beam having a pulse energy and pulse repetition rate; a high frequency fast scanner; an XY-scan device; a Z- scan device; and a controller. The controller controls the high frequency scanner to produce a scan line having a scan width; controls the XY-scan device and the Z-scan device to carry out of first sweep of the scan line in a first sweep direction and to carry out a second sweep of the scan line in a second sweep direction that is not parallel to the first sweep direction thereby defining an overlap region. At least one of the pulse energy, repetition rate, XY-scan speed, and the scan width is varied so as to accelerate the cutting speed and reduce the exposure of ophthalmic tissue in the overlap region to multiple exposures of laser pulses configured to modify ophthalmic tissue.

公开(公告)号：WO2019001795A1

公开(公告)日：2019-01-03

申请号：PCT/EP2018/060114

申请日：2018-04-19

Applicant: CARL ZEISS MEDITEC AG

Inventor： POMRAENKE, Robert ,  BERGT, Michael ,  HAMANN, Thomas ,  EBERSBACH, Ralf

IPC: A61B90/00 ,  A61B3/10 ,  A61B3/13 ,  A61F9/008 ,  G01B9/02 ,  A61B3/00

Abstract: Die Erfindung betrifft ein Verfahren zur Korrektur einer Abbildung, die auf einer Untersuchung eines Targets (900) mit einem Untersuchungsstrahl einer Vorrichtung für die optische Kohärenztomographie basiert, wobei sich die optische Weglänge und/oder die Polarisation des Untersuchungsstrahls zum und/oder vom Target während der Erzeugung der Abbildung diskret oder kontinuierlich verändert. Die Erfindung betrifft weiterhin ein ophthalmologisches Untersuchungssystem und eine Korrektureinheit. Ihre Aufgabe ist es, ein Verfahren und entsprechende Systeme aufzuzeigen, mit denen in einem Untersuchungssystem, in der eine optische Weglänge und/oder eine Polarisation eines Untersuchungsstrahls zum Target veränderlich ist, eine nichtmodifizierte und also unverfälschte Abbildung (einer Struktur) eines Targets erzeugt werden kann. Diese Aufgabe wird gelöst durch ein Verfahren und entsprechende Systeme, in denen die bekannten oder gemessenen Änderungen zur Einstellung eines verstellbaren Korrekturelements oder aber zur direkten Korrektur der Abbildung bzw. der Bilddaten der Abbildung verwendet wird, derart, dass der Einfluss der Änderung der optischen Weglänge des Untersuchungsstrahls zum und/oder vom Target und/oder ihrer Polarisation auf die Abbildung ausgeglichen wird.

公开(公告)号：WO2018158653A1

公开(公告)日：2018-09-07

申请号：PCT/IB2018/051038

申请日：2018-02-20

Applicant: NOVARTIS AG

Inventor： DIAO, Chenguang ,  FARLEY, Mark Harrison ,  MIRSEPASSI, Alireza ,  SMITH, Ronald T.

IPC: A61B18/22 ,  A61F9/008 ,  F21V8/00 ,  G02B6/04 ,  G02B6/26 ,  G02B6/36

Abstract: Multi-fiber laser probes utilize relative motion of fibers and other laser probe elements to preserve small-gauge compatibility while providing for multi-spot beam deliver, or to provide for the selectively delivery of single-spot or multi-spot beam patterns. An example probe includes fibers having distal ends that are movable as a group onto a distal ramp element affixed to a distal end of a cannula, so that the distal ends of the fibers can be moved between a retracted position, in which the distal ends of the fibers are within the cannula or ramp element, and an extended position, in which distal ends of the fibers are guided by grooves or channels of the ramp so as to extend at least partially through external openings in the distal end of the laser probe and so as to be pointed angularly away from a longitudinal axis of the cannula.

公开(公告)号：WO2018158652A1

公开(公告)日：2018-09-07

申请号：PCT/IB2018/051036

申请日：2018-02-20

Applicant: NOVARTIS AG

Inventor： DIAO, Chenguang ,  FARLEY, Mark Harrison ,  MIRSEPASSI, Alireza ,  PARTO, Kambiz ,  SMITH, Ronald T.

IPC: A61F9/008 ,  A61B18/22 ,  G02B6/04 ,  G02B6/24

Abstract: An example multi-fiber, multi-spot laser probe comprises a plurality of fibers extending from a proximal end of the laser probe to at least near a distal end of the laser probe, where the proximal end of the laser probe is configured to be coupled to a laser source via an adapter interface, and a cannula having a distal end and surrounding the plurality of fibers along at least a portion of the laser probe at or near the distal end of the laser probe, where a distal end of each of the plurality of fibers is angle-polished so that the distal end of each fiber is angled relative to a longitudinal axis of the cannula and relative to a plane perpendicular to the longitudinal axis of the cannula. Additional embodiments employ lensed fibers, a distal window, ball lens, lens array, or faceted wedge.

公开(公告)号：WO2018144644A1

公开(公告)日：2018-08-09

申请号：PCT/US2018/016307

申请日：2018-01-31

Applicant: OPTIMEDICA CORPORATION

Inventor： SCHUELE, Georg ,  DEWEY, David A. ,  GONZALEZ, Javier G. ,  VANKOV, Alexander

IPC: A61F9/008

Abstract: A laser surgical method for performing a corneal incision while maintaining iris exposure below a predetermined exposure limit includes : determining an initial iris exposure based on an initial treatment scan, determining whether the initial iris exposure is less than the predetermined exposure limit; generating a revised treatment scan comprising one or more treatment scan modifying elements when the initial iris exposure is greater than the predetermined exposure limit, and scanning the focal zone of a pulsed laser beam according to the revised treatment scan, thereby performing the corneal incision, wherein the one or more treatment scan modifying elements causes the iris exposure to be smaller than the predetermined exposure limit.

公开(公告)号：WO2018138552A1

公开(公告)日：2018-08-02

申请号：PCT/IB2017/050463

申请日：2017-01-28

Applicant: NOVARTIS AG

Inventor： MARTIN, Peter ,  GRAMPP, Jörg

IPC: A61F9/009 ,  A61F9/008

Abstract: The present disclosure provides a one-piece patient interface for single-stage docking of a femtosecond laser. The one-piece patient interface includes an upper circular portion, a lower conical portion integrally formed with the upper circular portion, an applanation plate in the lower conical portion, and a vacuum connection. The applanation plate may be at least partially coated with an applanation plate coating that is substantially transparent to treatment wavelengths of the femtosecond laser and substantially reflective to non-treatment wavelengths. The disclosure further provides a method for single-stage docking of a femtosecond laser and a system for cutting a flap on an eye using a femtosecond laser.

公开(公告)号：WO2018080974A1

公开(公告)日：2018-05-03

申请号：PCT/US2017/057827

申请日：2017-10-23

Applicant: EXCEL-LENS, INC.

Inventor： MORDAUNT, David

IPC: A61B18/18 ,  A61B18/20 ,  A61F2/16 ,  A61F9/00 ,  A61F9/007 ,  A61F9/008 ,  A61F9/009

Abstract: Laser assisted cataract surgery methods and devices utilize one or more treatment laser beams to create a shaped opening in the anterior lens capsule of the eye when performing a capsulotomy procedure. The visual axis of the eye may be determined, during surgery for example, with a laser beam on which the patient is fixated. The capsulotomy may be centered on the identified visual axis. This enables the use of capsulotomy-centering IOLs centered on or in close proximity to the visual axis. The orientation of a toric IOL may be assessed during or after placement by observing the reflection from the back of the eye of a laser beam on which the patient is fixated.

Abstract translation: 激光辅助白内障手术方法和装置在执行囊切术手术时利用一个或多个治疗激光束在眼睛的前晶状体囊中形成成形开口。 例如，在手术期间，可以用患者固定在其上的激光束来确定眼睛的视轴。 囊切开术可以以识别的视轴为中心。 这使得使用以视轴为中心或靠近视轴的以囊切开术为中心的IOL成为可能。 通过观察患者固定的激光束的眼睛后部的反射，可以在放置过程中或放置后评估环面IOL的取向。

公开(公告)号：WO2018053489A1

公开(公告)日：2018-03-22

申请号：PCT/US2017/052224

申请日：2017-09-19

Applicant: EXCEL-LENS, INC.

Inventor： MORDAUNT, David

IPC: A61F9/007 ,  A61F9/008

CPC classification number: A61F9/00825 ,  A61F9/007 ,  A61F9/00754 ,  A61F9/008 ,  A61F2009/0087 ,  A61F2009/00889

Abstract: Laser assisted cataract surgery methods and devices utilize one or more treatment laser beams to create a shaped opening in the anterior lens capsule of the eye when performing a capsulorrhexis procedure. A light absorbing agent may be applied to the anterior lens capsule to facilitate laser thermal separation of tissue along a treatment beam path on the lens capsule. Relative or absolute reflectance from the eye, and optionally from a surgical contact lens, may be measured to confirm and optionally quantify the presence of the light absorbing agent, before the treatment beam is applied. Such measurements may be used to determine that sufficient light absorbing agent is present in the lens capsule so that transmission of the treatment beam through the capsule will be below a predetermined threshold deemed safe for the retina and other interior portions of the eye, and may also be used to determine that sufficient light absorbing agent is present to result in complete laser thermal separation of the anterior capsule along the treatment beam path. Visualization patterns produced with one or more target laser beams may be projected onto the lens capsule tissue to aid in the capsulorrhexis procedure. In addition or alternatively, virtual visualization patterns may presented on a display integrated with a laser assisted cataract surgery device to aid in the procedure. The visual axis of the eye may be determined, during surgery for example, with a laser beam on which the patient is fixated. The orientation of a toric IOL may be assessed during or after placement by observing the reflection from the back of the eye of a laser beam on which the patient is fixated. The devices disclosed herein may be attached to or integrated with microscopes.

Abstract translation: 激光辅助白内障手术方法和装置利用一个或多个治疗激光束在进行囊袋取出手术时在眼睛的前晶状体囊中形成成形开口。 可以将光吸收剂施加到晶状体前囊以促进组织沿着晶状体囊上的治疗光束路径的激光热分离。 在施加治疗束之前，可以测量来自眼睛以及可选地来自外科接触镜片的相对或绝对反射率，以确认并任选地量化光吸收剂的存在。 这样的测量结果可以用于确定在晶状体囊中存在足够的光吸收剂，使得治疗光束穿过囊的传输将低于对视网膜和眼睛的其他内部部分视为安全的预定阈值，并且还可以 被用于确定存在足够的光吸收剂以导致沿着治疗光束路径完成前囊的激光热分离。 用一个或多个目标激光束产生的可视化图案可以被投影到晶状体囊组织上以帮助囊切除手术。 另外或可选地，虚拟可视化图案可呈现在与激光辅助白内障手术装置集成的显示器上以辅助该手术。 例如，在手术期间，可以用患者固定在其上的激光束来确定眼睛的视轴。 通过观察患者固定的激光束的眼睛后部的反射，可以在放置期间或之后评估环面IOL的取向。 本文所公开的装置可以附接到显微镜或与显微镜集成。

公开(公告)号：WO2018052418A1

公开(公告)日：2018-03-22

申请号：PCT/US2016/051776

申请日：2016-09-14

Applicant: OPTIMEDICA CORPORATION

Inventor： SCHUELE, Georg ,  GOODING, Phillip H. ,  ANGELEY, David ,  WANG, Zhao

IPC: A61F9/009 ,  A61F9/008

Abstract: Systems and methods here may be used to support a femtosecond laser eye surgery system including utilizing a floating head and/or patient support to maintain alignment of the system with a patient using feedback loops of force sensors in a patient interface. In some examples, the floating head and/or patient support may counteract movements detected in the force sensors. In some example embodiments, a ranging subsystem may detect and compensate for different arrangements of the floating head assembly using a ranging sample beam.

Abstract translation: 这里的系统和方法可用于支持飞秒激光眼科手术系统，包括利用浮动头部和/或患者支撑件以使用反馈回路中的力传感器来维持系统与患者的对准 患者接口。 在一些示例中，浮动头部和/或患者支撑可以抵消在力传感器中检测到的运动。 在一些示例实施例中，测距子系统可以使用测距样本光束检测并补偿浮动头组件的不同布置。

公开(公告)号：WO2018033770A1

公开(公告)日：2018-02-22

申请号：PCT/IB2016/054907

申请日：2016-08-16

Applicant: STROMA MEDICAL CORPORATION

Inventor： HOMER, Gregg Stanley

IPC: A61F9/008

Abstract: The invention predicts a patient's post-op iris color by irradiating the patient's iris and then using image sensors to collect images and/or other data from the iris stroma posterior to the stromal pigment. These images and/or other data are then analyzed and compared to database images and/or other data associated with non-pigmented irides to arrive at a prediction for the patient's post-op iris color.

Abstract translation: 本发明通过照射患者的虹膜并且然后使用图像传感器从基质色素后面的虹膜基质收集图像和/或其他数据来预测患者的术后虹膜颜色。 然后分析这些图像和/或其他数据，并将其与数据库图像和/或与非色素虹膜相关的其他数据进行比较，以得出患者术后虹膜色彩的预测。