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公开(公告)号：WO1997040791A1
公开(公告)日：1997-11-06
申请号：PCT/US1997005092
申请日：1997-03-25
Applicant: MEDTRONIC, INC.
Inventor： MEDTRONIC, INC. , TESTERMAN, Roy, L. , ERICKSON, Donald, J. , MEZERA, Ronald, L. , NEISZ, Johann, J.
IPC: A61F09/007
CPC classification number: A61N1/36046 , A61F9/00718 , A61N1/05
Abstract: The implantable eyelid electrode apparatus includes a body of nonconductive material having first and second edges and first and second ends. A longitudinal axis extends between the first and second ends and a distance from the longitudinal axis to at least one of the first and second edges decreases towards at least one of the first and second ends. Conductive material is positioned at a surface of the body and at least one lead wire is in electrical contact with the conductive material. Further, the conductive material may include a number of conductive electrodes which are capable of being connected as an anode, a cathode, or left in an open configuration. The conductive electrodes may be strip electrodes positioned perpendicular to the longitudinal axis, and further, the plurality of conductive electrodes may be configured in a guarded multipolar configuration. An electrode device may be implanted in the upper eyelid or the lower eyelid or both. Moreover, a method for implanting an electrode apparatus includes positioning the electrode apparatus adjacent the orbicularis oculi muscle fiber such that the conductive material of the implantable eyelid electrode is adjacent the surface of the muscle fibers. The conductive electrodes, which may be of a strip configuration, are positioned with their length perpendicular to the muscle fibers, when implanted, to promote current passing parallel to the muscle fibers.
Abstract translation: 可植入式眼睑电极装置包括具有第一和第二边缘以及第一和第二端的非导电材料体。 纵向轴线在第一和第二端部之间延伸，并且从纵向轴线到第一和第二边缘中的至少一个的距离朝着第一和第二端部中的至少一个减小。 导电材料位于主体的表面，并且至少一根引线与导电材料电接触。 此外，导电材料可以包括能够作为阳极连接的多个导电电极，阴极，或者处于打开构型的左侧。 导电电极可以是垂直于纵向轴线定位的带状电极，此外，多个导电电极可以被配置成保护的多极配置。 电极装置可以植入上眼睑或下眼睑或两者。 此外，用于植入电极装置的方法包括将电极装置定位在眼轮匝肌纤维附近，使得可植入眼睑电极的导电材料邻近肌肉纤维的表面。 当植入时，可以具有带状构造的导电电极的长度与肌肉纤维垂直，以促进平行于肌肉纤维的电流通过。
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公开(公告)号：WO1997006751A1
公开(公告)日：1997-02-27
申请号：PCT/US1996013277
申请日：1996-08-16
Applicant: MASSACHUSETTS EYE AND EAR INFIRMARY
IPC: A61F02/16
CPC classification number: A61F2/1635 , A61F2/1613 , A61F9/08 , A61N1/36046 , G02B3/14
Abstract: Dynamically functional intra-ocular prosthesis. The prosthesis includes an implantable intra-ocular lens and microelectronic components mounted on the lens. One embodiment is a variable focal length implantable intra-ocular lens system for adjusting the focal length of the implantable lens. In one embodiment, a micromotor changes the tension in a band encircling the peripheral portion of the deformable lens changing its shape to vary its focal length. Another embodiment is an artificial intra-ocular lens which serves as a holding substrate for microelectronic components that form part of a prosthesis to stimulate the neural elements of the eye to restore vision to patients who are blind from retinal disease.
Abstract translation: 动态功能性眼内假体。 假体包括可植入的眼内透镜和安装在透镜上的微电子部件。 一个实施例是用于调节可植入透镜的焦距的可变焦距可植入眼内透镜系统。 在一个实施例中，微电机改变围绕可变形透镜的周边部分的带的张力，改变其形状以改变其焦距。 另一个实施方案是人造眼内透镜，其用作形成假体的一部分的微电子部件的保持基底，以刺激眼睛的神经元件以恢复对视网膜疾病失明的患者的视力。
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公开(公告)号：WO1994026209A1
公开(公告)日：1994-11-24
申请号：PCT/US1994004656
申请日：1994-04-28
Applicant: CHOW, Alan, Y.
IPC: A61F02/16
CPC classification number: A61N1/0543 , A61F9/00727 , A61F9/08 , A61N1/36046 , H01L27/14643
Abstract: Microscopic photo-diode devices (10) with semi-transparent surface electrodes are combined with a liquid or other suitable vehicle and injected into the sub-retinal space in order to transduce incident light into electric current which stimulate the overlying cellular layers of the retina. The devices may be micro-spheres, micro-cylinders or other shapes. An off center embedded ferromagnetic layer will confer magnetic susceptibility to the devices and an applied magnetic field will align them within the sub-retinal space directing their photoactive surface toward incident light. Alternatively, they may be embedded, pre-aligned, in a transparent flexible sheet (122) permeable to nutrients and oxygen before implantation into the sub-retinal space. The sheet will dissolve leaving separate units behind in an arranged pattern. The devices may be of the PiN-type or NiP-type or a combination of both. An electric capacitor layer (146) may also be incorporated into the device to allow charge storage during exposure to light and charge release in darkness producing an opposite polarity current.
Abstract translation: 具有半透明表面电极的显微光电二极管器件（10）与液体或其它合适的载体组合，并注入到子视网膜空间中，以将入射光转换成刺激视网膜上层细胞层的电流。 这些装置可以是微球，微圆柱体或其他形状。 偏心中心的嵌入铁磁层将赋予器件磁化率，并且所施加的磁场将使它们在副视网膜空间内对齐，以将它们的光活性表面引向入射光。 或者，它们可以在植入次视网膜空间之前嵌入，预对准，在可渗透营养物和氧气的透明柔性片（122）中。 片材将以排列的图案溶解留下单独的单元。 这些装置可以是PiN型或NiP型或两者的组合。 电容器层（146）也可以并入设备中以允许在曝光期间的电荷存储并且在黑暗中的电荷释放产生相反的极性电流。
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公开(公告)号：WO1992007617A1
公开(公告)日：1992-05-14
申请号：PCT/US1990006574
申请日：1990-11-09
Applicant: PHYSIODYNAMICS, INC.
Inventor： PHYSIODYNAMICS, INC. , THOMAS, Gary, E. , FELLINGER, Michael, W.
IPC: A61N01/18
CPC classification number: A61N1/323 , A61N1/0452 , A61N1/0456 , A61N1/0472 , A61N1/36017 , A61N1/36021 , A61N1/36046
Abstract: The present invention involves a method of treating a patient by providing a signal that is exponential in character (82) to the patient (84). The signal includes a relatively low-frequency, constant amplitude, periodic-exponential first component (86). Further, the signal preferably includes a relatively high-frequency, periodic-exponential second component (78). The present invention also includes a method and apparatus for noninvasively applying an electrical signal to a structure associated with the eye of the patient (170). The signal is provided to the structure associated with the eye in the preferred embodiment of the invention by positioning a device for conducting the electrical signal (172a, 172b) at a point on the exterior of the patient that is substantially interior to the bone structure (224, 226) defining the eye socket. Preferably, the electrical signal is shaped such that an electrical charge is imparted to one or more structures associated with the eye.
Abstract translation: 本发明涉及一种通过向患者（84）提供特征（82）指数的信号来治疗患者的方法。 信号包括相对低频，恒定幅度的周期性指数的第一分量（86）。 此外，信号优选地包括相对高频的周期性指数的第二分量（78）。 本发明还包括用于将电信号非侵入性地应用于与患者眼睛相关联的结构（170）的方法和装置。 在本发明的优选实施例中，通过在基本上位于骨结构内部的患者外部的位置处定位用于传导电信号（172a，172b）的装置，将信号提供给与眼睛相关联的结构（ 224,226）限定眼窝。 优选地，电信号被成形为使得电荷被赋予与眼睛相关联的一个或多个结构。
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65.发明申请
公开(公告)号：WO2017144421A1
公开(公告)日：2017-08-31
申请号：PCT/EP2017/053812
申请日：2017-02-20
Applicant: CARL ZEISS AG
Inventor： KINDT, Johannes , DOBSCHAL, Hans-Jürgen
CPC classification number: A61F2/14 , A61F2250/0001 , A61N1/36046 , A61N1/3787
Abstract: Es werden eine Vorrichtung und Verfahren bereitgestellt, mit welchen ein Retinaimplantat (12) über Infrarotstrahlung mit Energie versorgt werden kann. Hierzu wird Infrarotlicht von einer Infrarotlichtquelle (14) beispielsweise in ein Brillenglas (13) eingekoppelt und durch eine Auskoppeleinrichtung (17) zu einem Auge (10) hin ausgekoppelt, um das Retinaimplantat (12) zu beleuchten.
Abstract translation: 提供了一种装置和方法，通过该装置和方法，视网膜植入物（12）可以通过红外辐射供电。 用于此目的的红外光到眼睛（10）从由红外光源（14），例如，在联接的眼镜镜片（13）和由连接到照亮视网膜植入物（12）耦合输出装置（17）。
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66.发明申请ELECTRODE SYSTEM, DEVICE AND METHOD FOR THE TREATMENT OF EYE DISEASES, IN PARTICULAR DRY EYE 审中-公开用于治疗眼部疾病，特别是干眼的电极系统，装置和方法
公开(公告)号：WO2017072575A1
公开(公告)日：2017-05-04
申请号：PCT/IB2016/001541
申请日：2016-10-27
Applicant: RESONO OPHTHALMIC S.R.L.
Inventor： DE TONI, Alessandro , POZZATO, Alessandro , POZZATO, Gianantonio , RUGGERI, Alfredo , SCARAMUZZA, Matteo , TRANI, Antonio
CPC classification number: A61N1/06 , A61N1/0484 , A61N1/36046
Abstract: The invention proposes an electrode system (2; 100) for treating dry eye, comprising one or more electrodes wherein (a) a portion of said one or more electrodes intended to be applied in contact with the eye, the eye orbit, the temple, the eyelid areas or a part of them respectively imitates the shape of the eye surface, the eye orbit, the temple, the eyelid areas or a part of them or wherein (b) a portion of said one or more electrodes intended to be applied in contact with the eye, the eye orbit, the temple, the eyelid areas or a part of them is flexible and adaptable in its shape in such a way that in the cases (a) and (b) a form-fit coupling is achievable between said portion of said one or more electrodes and the surface shape of the eye, the eye orbit, the temple, the eyelid areas or a part of them. Said portion of said one or more electrodes is fed or feedable with an electromagnetic wave of distorted sinusoidal current with a resonance frequency, preferably a 4 MHz resonance frequency, which includes the related harmonics, preferably at least the second and the third harmonic. The invention also relates to a corresponding electrostimulation device, a method for the treatment of dry eye and uses of the electrode system and of the electrostimulation device for the treatment of other diseases of the eye.
Abstract translation: 本发明提出了一种用于治疗干眼症的电极系统（2; 100），其包括一个或多个电极，其中（a）所述一个或多个电极的一部分旨在与眼睛接触 眼眶区域或眼睑区域或它们的一部分分别模仿眼球表面，眼球轨道，太阳穴，眼睑区域或它们的一部分的形状，或者其中（b）所述一个 或更多旨在与眼睛，眼睛轨道，眼眶，眼睑区域或其一部分接触而应用的电极在其形状方面是灵活的和适应性的，使得在情况（a）和（b）中， 在所述一个或多个电极的所述部分与眼睛的表面形状，眼睛轨道，眼镜腿，眼睑区域或它们的一部分之间可以实现形状配合连接。 所述一个或多个电极的所述部分以谐振频率，优选为4MHz谐振频率的畸变正弦电流的电磁波馈送或馈送，该谐振频率包括相关谐波，优选至少第二和第三谐波。 本发明还涉及相应的电刺激装置，干眼治疗方法以及电极系统和电刺激装置用于治疗其他眼疾的用途。
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公开(公告)号：WO2017012032A1
公开(公告)日：2017-01-26
申请号：PCT/CN2015/084603
申请日：2015-07-21
Applicant: 林伯刚
Inventor： 林伯刚
IPC: A61F2/14
CPC classification number: A61N1/36046 , A61N1/0543
Abstract: 一种光源驱动的视网膜芯片(3)，接收一信号光(X)及一背景光(Y)，所述光源驱动的视网膜芯片(3)包括：一光电二极管阵列(31)，包含多个光电二极管(311)及多个电流放大电路(312)，其中，所述多个光电二极管(311)将所述信号光(X)转换成一电信号，以及将背景光(Y)转换成多个背景光电流，所述多个电流放大电路(312)放大电信号及所述多个背景光电流；以及多个背景光消减单元(32)，包含多个背景光感测电路及多个电流消减电路，其中，所述多个电流消减电路加权电信号并消减所述多个背景光电流，进而增强光源驱动的视网膜芯片(3)的动态范围。
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公开(公告)号：WO2016180535A1
公开(公告)日：2016-11-17
申请号：PCT/EP2016/000776
申请日：2016-05-12
Applicant: PIXIUM VISION SA
Inventor： DETERRE, Martin
CPC classification number: H01L27/1446 , A61N1/0543 , A61N1/36046 , H01L28/20 , H01L31/02019
Abstract: The present invention relates to a photosensitive pixel structure (10). The pixel structure (10) comprises a substrate (15) and at least one photosensitive diode (12, 12', 12"), a stimulating electrode (14), and a resistor (16). The resistor (1 6) is electrically connecting the stimulating electrode (14) and a counter electrode (18). Further, the resistor (16) is at least partially covered by the stimulating electrode (14) and/or the resistor (16) is at least partially covered by the counter electrode (18).
Abstract translation: 本发明涉及光敏像素结构（10）。 像素结构（10）包括衬底（15）和至少一个感光二极管（12,12'，12“），刺激电极（14）和电阻器（16），电阻器（116）是电 连接刺激电极（14）和对电极（18），此外，电阻器（16）至少部分地被刺激电极（14）覆盖和/或电阻器（16）至少部分地被计数器覆盖 电极（18）。
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69.发明申请
公开(公告)号：WO2016044296A1
公开(公告)日：2016-03-24
申请号：PCT/US2015/050226
申请日：2015-09-15
Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. , GREENBERG, Robert, J. , ROY, Arup , CASPI, Avraham, I. , PATEL, Uday , WELCH, Mark, D.
Inventor： GREENBERG, Robert, J. , ROY, Arup , CASPI, Avraham, I. , PATEL, Uday , WELCH, Mark, D.
CPC classification number: A61N1/36046 , A61N1/0543 , G06K9/00671 , G06K9/00805 , G09B21/008 , H04N5/2252 , H04N13/128 , H04N13/239 , H04N2013/0081
Abstract: Systems and methods for detecting and displaying obstacles to visually impaired persons are disclosed. Images from a captured scene are analyzed to detect obstacles. A V-Disparity algorithm is employed to detect the ground plane and remove it from the images, thereby enhancing the capacity of retinal implants to display only obstacles. The system includes cameras to capture images; a processor with memory to detect obstacles in the captured images, to remove a ground plane, and to calculate a map of pixels representing the obstacles; and a retinal implant configured to receive the map of pixels and display the obstacles to a system user by electrically stimulating retinal nerves. The method includes synchronizing captured images and calculating a disparity map between the captured images to detect obstacles and remove a ground plane from processed images. A map of pixels representing the obstacle is transmitted to a retinal implant. Depth information may derive from stereo cameras, a time of flight camera or a structured light camera.
Abstract translation: 公开了用于检测和显示障碍物的障碍物的系统和方法。 分析捕获场景中的图像以检测障碍物。 采用V-Disparity算法来检测地平面并将其从图像中去除，从而增强视网膜植入物仅显示障碍物的能力。 该系统包括拍摄图像的相机; 具有存储器的处理器，用于检测所捕获的图像中的障碍物，以去除接地平面，并计算表示障碍物的像素的图; 以及视网膜植入物，被配置为接收像素的图并且通过电刺激视网膜神经将障碍物显示给系统用户。 该方法包括同步捕获的图像并计算所捕获的图像之间的视差图，以检测障碍物并从经处理的图像中移除接地平面。 将表示障碍物的像素的图像发送到视网膜植入物。 深度信息可以来自立体相机，飞行时间相机或结构光照相机。
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公开(公告)号：WO2015143203A1
公开(公告)日：2015-09-24
申请号：PCT/US2015/021543
申请日：2015-03-19
Applicant: SCHEPENS EYE RESEARCH INSTITUTE
Inventor： PELI, Eliezer , JUNG, Jae-Hyun
CPC classification number: A61F9/08 , A61H3/061 , A61H2003/063 , A61H2201/165 , A61H2201/5038 , A61H2201/5048 , A61H2201/5084 , A61H2201/5092 , A61H2201/5097 , A61N1/0543 , A61N1/36046
Abstract: The disclosure features systems for providing information to a user about the user's environment, the system featuring a detection apparatus configured to obtain image information about the environment, where the image information corresponds to information at multiple distances relative to a position of the user within the environment, and an electronic processor configured to obtain focal plane distance information defining a set of one or more distance values relative to the position of the user within the environment, construct one or more confocal images of the environment, from the image information and the set of one or more distance values, wherein each of the one or more confocal images corresponds to a different distance value and comprises a set of pixels, and transform the one or more confocal images to form one or more representative images comprising fewer pixels and a lower dynamic range.
Abstract translation: 该公开内容特征在于向用户提供关于用户环境的信息的系统，该系统具有被配置为获得关于环境的图像信息的检测装置，其中图像信息对应于相对于环境中的用户位置的多个距离的信息 以及电子处理器，被配置为获得焦平面距离信息，所述焦平面距离信息定义相对于所述环境内的所述用户的位置的一个或多个距离值的集合，从所述图像信息和所述图像信息的集合中构建所述环境的一个或多个共焦图像 一个或多个距离值，其中所述一个或多个共焦图像中的每一个对应于不同的距离值并且包括一组像素，并且变换所述一个或多个共焦图像以形成包括较少像素和较低像素的一个或多个代表图像 范围。
