公开(公告)号：WO2008060476A3

公开(公告)日：2008-12-24

申请号：PCT/US2007023669

申请日：2007-11-09

Applicant: SCHERING CORP ,  PALANI ANANDAN ,  SU JING ,  XIAO DONG ,  HUANG XIANHAI ,  RAO ASHWIN U ,  CHEN XIAO ,  TANG HAIQUN ,  QIN JUN ,  HUANG YING R ,  ASLANIAN ROBERT G ,  MCKITTRICK BRIAN A ,  DEGRADO SYLVIA J

Inventor： PALANI ANANDAN ,  SU JING ,  XIAO DONG ,  HUANG XIANHAI ,  RAO ASHWIN U ,  CHEN XIAO ,  TANG HAIQUN ,  QIN JUN ,  HUANG YING R ,  ASLANIAN ROBERT G ,  MCKITTRICK BRIAN A ,  DEGRADO SYLVIA J

IPC: C07D471/04 ,  A61K31/436 ,  A61K31/519 ,  A61P3/00 ,  A61P3/10 ,  A61P9/00 ,  C07D491/04

CPC classification number: C07D491/04 ,  C07D471/04

Abstract: The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: (a), (b), (c), (d) and (e); and L is selected from the group consisting of: (f), (g), (h), and (i); pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).

Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐，溶剂合物，酯和互变异构体，其中：Q选自：（a），（b），（c），（d）和 （E）; 并且L选自：（f），（g），（h）和（i）; 包含一种或多种式（I）化合物的药物组合物，以及使用式（I）化合物的方法。

公开(公告)号：WO2006065654A1

公开(公告)日：2006-06-22

申请号：PCT/US2005/044647

申请日：2005-12-07

Applicant: SCHERING CORPORATION ,  XIAO, Dong ,  PALANI, Anandan ,  WANG, Cheng ,  TSUI, Hon-chung ,  HUANG, Xianhai ,  SHAH, Sapna, S. ,  RAO, Ashwin, U. ,  CHEN, Xiao ,  PALIWAL, Sunil ,  SHIH, Neng-yang

Inventor： XIAO, Dong ,  PALANI, Anandan ,  WANG, Cheng ,  TSUI, Hon-chung ,  HUANG, Xianhai ,  SHAH, Sapna, S. ,  RAO, Ashwin, U. ,  CHEN, Xiao ,  PALIWAL, Sunil ,  SHIH, Neng-yang

IPC: C07D471/18 ,  C07D498/18 ,  C07D471/22 ,  C07D498/22 ,  A61K31/48 ,  A61K31/4375 ,  A61P25/22

CPC classification number: C07D471/08

Abstract: A compound having the general structure shown in Formula (I): or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

Abstract translation: 具有式（I）所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑 咳嗽