ENZYME LINKED ASSAY METHODS AND APPARATUSES
    2.
    发明申请

    公开(公告)号:WO2020193934A1

    公开(公告)日:2020-10-01

    申请号:PCT/GB2020/050267

    申请日:2020-02-06

    Inventor: LEE, Andrew

    Abstract: A method of measuring a concentration of a target analyte (17) using an enzyme linked assay is described. The enzyme linked assay is conducted using a fluidic device (1) including one or more flow cells (2). Each flow cell (2) includes a channel (7) and at least two ports (8a, 8b) in fluid communication with the channel (7). At least one internal surface (9) of each channel (7) is functionalised with a capture molecule (10) which enables functionalising the flow cell (2) using an enzyme linked assay applied to a sample (12). The capture molecules will immobilise complexes of enzyme molecules bound to target analyte. The fluidic device (1) also includes a photodiode (3) corresponding to each flow cell (2) and arranged to receive light (11) from the corresponding flow cell (2). Each photodiode (3) is attached to the corresponding flow cell (2) or each photodiode (3) is integrally formed with the corresponding flow cell (2). The method includes, for a flow cell (2) of the fluidic device (1), functionalising the flow cell (2) using an enzyme linked assay applied to a sample (12), such that in response to the sample (12) contains the target analyte (17), the flow cell (2) will become functionalised with an immobilised concentration (21) of enzyme molecules (15) bound to the target analyte (21). The method also includes, for each flow cell (2), introducing a substrate (23) to the flow cell. The substrate (23) is convertible into a reporting substance (24) by the enzyme molecules (15). The method also includes recording, using the photodiode (3) corresponding to the flow cell (2), a time series (3) of measured values corresponding to an optical property of the flow cell (2) which depends on a concentration of the reporting substance (24). The method also includes determining a first time point (t 1 ) corresponding to the introduction of the substrate (23) to the flow cell (2). The method also includes determining a second time point (t 2 ) corresponding to an endpoint of linear kinetics for the conversion of substrate (23) into reporting substance (24). The method also includes estimating, based on the measured values obtained between the first and second time points (t 1 , t 2 ), a concentration of the target analyte (17) in the sample.

    THERMOELECTRIC DEVICE
    4.
    发明申请

    公开(公告)号:WO2020058689A1

    公开(公告)日:2020-03-26

    申请号:PCT/GB2019/052602

    申请日:2019-09-17

    Abstract: A thermoelectric device includes each an n-type thermoelectric leg and a p-type thermoelectric leg electrically coupled by an electrical contact. At least one of the n-type and p-type thermoelectric legs contains a particulate semiconductor mixed with hollow microspheres. The hollow microspheres may make up between 40 % and 90 % by volume of the thermoelectric leg. Adjacent thermoelectric couples may be electrically coupled by a second electrical contact. The thermoelectric legs may be printed by deposition of an ink.

    DE-DOPED THERMOELECTRIC MATERIAL
    7.
    发明申请

    公开(公告)号:WO2019175531A1

    公开(公告)日:2019-09-19

    申请号:PCT/GB2019/050438

    申请日:2019-02-19

    Abstract: A thermoelectric material is provided that is a blend of an inherently-doped-organic- semiconducting material and a de-doping agent. The inherently-doped-organic- semiconducting material may be a semiconducting polymer. The inherently-doped-organic- semiconducting material is inherently doped and is conductive. The de-doping agent may be used to tune both the conductivity and the Seebeck coefficient of the inherently-doped- organic-semiconducting material. The thermoelectric material may be used as one of the legs of a thermoelectric device. The thermoelectric material may be formed by adding a de- doping agent to an n-doped or p-doped organic semiconductor. The organic semiconductor formed by this method may be used to form a p-type or n-type thermoelectric leg of a thermoelectric device.

    MAGNETIC PHASE TRANSITION COMPOSITE MATERIAL

    公开(公告)号:WO2019138253A1

    公开(公告)日:2019-07-18

    申请号:PCT/GB2019/050098

    申请日:2019-01-15

    CPC classification number: H01F1/0063 H01F1/0054 H01F1/012 H01F1/017

    Abstract: A phase transition composite material (1) includes a dispersion of single-domain magnetic nanoparticles (2) and an elastic encapsulant (3) arranged to separate the nanoparticles (2). The composite material (1) is deformable between first and second states. In the first state the material is relaxed and in the second state the material is stressed. In the first state, the magnetizations of the magnetic nanoparticles (2) are less ordered (e.g., the magnetic nanoparticles (2) exhibit superparamagnetism) and, in the second state, the magnetizations of the magnetic nanoparticles (2) are more ordered (e.g., the magnetic nanoparticles (2) exhibit superferromagnetism or superantiferromagnetism).

    ORGANIC LIGHT EMITTING DEVICE
    9.
    发明申请

    公开(公告)号:WO2019002819A1

    公开(公告)日:2019-01-03

    申请号:PCT/GB2018/051614

    申请日:2018-06-13

    Inventor: BENZIE, Philip

    CPC classification number: H01L51/5275

    Abstract: A white light-emitting organic light-emitting device (100) with enhanced blue and/or near infrared spectral components. A transparent refractive layer (103) with a high refractive index is disposed between a transparent anode layer (105) and a transparent substrate layer (101). The difference in refractive index of the layers provides that light from a light emitting layer (107) is optically adjusted to enhanced blue and/or near infrared components. The high refractive index layer (103) behaves like a Fabry-Perot interferometer to optically enhance the blue/near infrared components of white light passing through the stack of transparent layers.

    READING DEVICE FOR A LATERAL FLOW TEST STRIP
    10.
    发明申请

    公开(公告)号:WO2018229477A1

    公开(公告)日:2018-12-20

    申请号:PCT/GB2018/051604

    申请日:2018-06-13

    CPC classification number: G01N21/8483

    Abstract: Reading device for a lateral flow test strip. A reading device (26) for a lateral flow test strip (2) includes a sample receiving volume (27) disposed between first and second faces (28, 29) spaced apart in a first direction (z). The sample receiving volume (27) is configured to receive at least a portion of a lateral flow test strip (2) between the first and second faces (28, 29) such that a longitudinal axis of the lateral flow test strip (2) is aligned in a second direction (x) transverse to the first direction (z). The reading device (26) also includes a light emitter (32) arranged to illuminate a reading portion (34) of the sample receiving volume (27). The reading device (26) also includes a photodetector (37) arranged to receive light from the reading portion (34). A width of the reading portion (34) in the second direction (x) is greater than a width of a test region (5) of the lateral flow test strip (2) in the second direction (x).

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