公开(公告)号：WO2021186284A1

公开(公告)日：2021-09-23

申请号：PCT/IB2021/051889

申请日：2021-03-06

Applicant: UNIVERSIDADE DO PORTO ,  BIOSCKIN, MOLECULAR & CELL THERAPIES S.A.

Inventor： MAURÍCIO, Ana ,  BRANDÃO, Ana ,  SIMÕES, Maria ,  MEIRELES, Carla ,  BARBOSA, Ana ,  ATAÍDE, Luís ,  MENDONÇA, Carla

IPC: A61L27/10 ,  A61L27/12 ,  A61L27/42 ,  A61L27/56

Abstract: The present invention relates to a method for producing hydroxyapatite-bioglass macroporous material, to said materials, and to medical devices thereof. The method comprises a step of preparation of an aqueous suspension of hydroxyapatite and bioglass with a porogenic agent, and subsequent sintering to achieve a macroporous biomaterial. The macroporous structure of these materials enhances blood vessels and bone cells migration, allowing bone growth through the interior of the bone substitute, thereby increasing the rate of formation of new bone at the site of implantation. Therefore, these materials are advantageously used to produce medical devices, such as bone grafts that resemble the mineral phase of natural bone showing improved mechanical strength and osteoconductivity. The biomaterials of the present invention are applicable in the medical area, in particular in bone regeneration and reparation techniques as bone grafts.

公开(公告)号：WO2021019466A1

公开(公告)日：2021-02-04

申请号：PCT/IB2020/057164

申请日：2020-07-29

Applicant: INSTITUTO POLITÉCNICO DE BEJA

Inventor： CARVALHO, Maria ,  REGATO, Mariana ,  ALMEIDA, Maria ,  PEREIRA, Nuno ,  CARVALHO, Maria ,  SANTOS, Maria ,  CORREIA, Tânia ,  AFONSO, Alexandra ,  LUZ, Silvana

IPC: C02F1/52 ,  A01G24/15 ,  A01G24/18 ,  A01G31/00 ,  A47F7/00 ,  A47G7/04 ,  C02F3/32 ,  C02F103/32

Abstract: A presente invenção diz respeito a um processo de produção de de alface (Lactuca sativa L.) , em sistemas hidropónicos, com utilização de águas residuais urbanas, domésticas e agroindustriais tratadas. O processo de tratamento das águas residuais envolve um passo de precipitação química básica e a neutralização natural do sobrenadante, por utilização do CO 2 atmosférico, e posterior aplicação do sobrenadante tratado em sistemas hidropónicos, para a cultura de alface, como solução nutritiva. Desta forma, a presente invenção insere-se na área do tratamento de efluentes, agricultura e culturas em hidroponia.

公开(公告)号：WO2019130219A1

公开(公告)日：2019-07-04

申请号：PCT/IB2018/060622

申请日：2018-12-26

Applicant: ANTUNES, Nuno

Inventor： ANTUNES, Nuno

IPC: A42B1/04 ,  A42B1/24 ,  A42C5/02

CPC classification number: A42B1/043 ,  A42B1/241 ,  A42C5/02

Abstract: A presente invenção refere-se a um artigo têxtil (T) criado para ser colocado na cabeça dos prestadores de cuidados de saúde. Este artigo é fabricado em material têxtil convencional, mas com propriedades específicas para uso em ambiente hospitalar, revestido externamente por uma camada em um material semipermeável, internamente por uma camada em um material transpirável e com função antimicrobiana, apresentando ainda, preferencialmente, uma camada intermédia com função de barreira antibacteriana. Para além disso, a existência de um bolso (P) permite, em simultâneo, ao seu utilizador armazenar, temporariamente e em segurança, pequenos objetos de uso pessoal.

公开(公告)号：WO2023281445A1

公开(公告)日：2023-01-12

申请号：PCT/IB2022/056303

申请日：2022-07-07

Applicant: TECHNOPHAGE, INVESTIGAÇÃO E DESENVOLVIMENTO EM BIOTECNOLOGIA, S.A. ,  FACULDADE DE MEDICINA VETERINÁRIA DA UNIVERSIDADE DE LISBOA

Inventor： SILVA, Frederico ,  GOMES, Joana ,  ANDRÉ, Ana ,  AGUIAR, Sandra ,  OLIVEIRA, Soraia ,  TAVARES, Luís

IPC: C07K16/30

Abstract: The present disclosure relates to the development of drug delivery systems comprising single domain antibodies (sdAbs). For this purpose, antibody-drug conjugates (ADCs) are provided with high selectivity and efficiency to be used advantageously in cancer therapy, and a drug-delivery system targeting the central nervous system (CNS) pathologies. The ADC molecules developed for therapy, namely for cancer therapy are obtained from rabbit derived sdAbs comprising a potent cytotoxic payload, a SN38 small molecule conjugated with the free exposed cysteine at position 80, 23 or 88 of the VL framework. The drug delivery systems developed targeting the BBB endothelial cell receptors of the central nervous system (CNS) comprise rabbit derived single-domain antibodies (sdAb) conjugated at the surface of liposomes encapsulated with a suitable drug enabling an efficient blood-brain barrier (BBB) translocation. The respective process of production is also herein disclosed. Therefore, the present disclosure is in the domain of genetic engineering, biotechnology, pharmaceuticals and medicine.

公开(公告)号：WO2020070700A3

公开(公告)日：2020-04-09

申请号：PCT/IB2019/058462

申请日：2019-10-04

Applicant: EXOGENUS THERAPEUTICS, SA

Inventor： CORREIA, Joana ,  CARDOSO, Renato ,  RODRIGUES, Sílvia

IPC: A61K35/51

Abstract: The present invention relates to a process for isolating Small Extracellular Vesicles secreted by umbilical cord blood mononuclear cells (UCBMNCs) and compositions comprising said Small Extracellular Vesicles, which are useful to be applied to autoimmune diseases therapeutics or prophylactics and/or cosmetic purposes. The proposed process for isolating UCBMNCs Small Extracellular Vesicles comprises three main steps: i) a first step of sequential centrifugation, ii) a second step of microfiltration combined with ultrafiltration (UF), and iii) a third step of size exclusion chromatography (SEC) and aims to achieve highly pure Small Extracellular Vesicles and in a higher yield. The SEVs compositions comprise specific type of proteins, RNA and lipids, that enables them to be very effective when applied to inflammatory and autoimmune diseases therapeutics, such as psoriasis, lupus, atopic dermatitis, eczema, etc. and also to cosmetic or prophylactic compositions. Therefore, the present invention lays in the technical domain of pharmaceuticals, medicine, cosmetics, research and development in cellular biology and appliances thereof.

公开(公告)号：WO2019244094A1

公开(公告)日：2019-12-26

申请号：PCT/IB2019/055209

申请日：2019-06-20

Applicant: LADEIRA, João

Inventor： LADEIRA, João

IPC: G08B17/00 ,  G08B17/06 ,  G08B17/117 ,  G08B25/00

Abstract: The present invention relates to a wildfire detection system that uses an array of CO 2 sensors (2) and artificial intelligence. This system comprises a sensorial unit (1), a gateway (G) to relay sensorial unit data to a designated server (R) and a software (S) with a designed algorithm for processing the incoming data and trigger the fire alarms whenever it is necessary. In another aspect, the present invention relates to a method of detecting an environmental fire in its early stage by using the system described herein. Therefore, the present invention is in the domain of electronic devices for detection of environmental fires.

公开(公告)号：WO2018178913A1

公开(公告)日：2018-10-04

申请号：PCT/IB2018/052167

申请日：2018-03-29

Applicant: UNIVERSIDADE DO ALGARVE

Inventor： JESUS, Sérgio ,  FELISBERTO, Paulo

IPC: G01V1/18 ,  G01V1/38

Abstract: The present invention relates to a dual a ccelerometer vector sensor (DAVS) device. Said device comprises two tri-axial accelerometers and one hydrophone moulded in one unit. Such device is useful to measure and improve the efficiency of methodologies used to perform geophysical acoustic surveys at sea. The DAVS has the potential to contribute to this aim in various ways, for example, owing to its spatial filtering capability, it may reduce the amount of post processing by discriminating the bottom from the surface reflections. Also its compact size allows easier integration with AUVs and hence facilitates the vehicle manoeuvrability compared to the classical towed arrays. Therefore, another object of the present invention refers to an Autonomous Underwater Vehicles (AUVs) comprising the DAVS device of the present invention for acquiring and monitoring underwater seismic data. The present invention is thus useful for acquiring and monitoring seismic data and belongs to the technical field of seismology, seismic prospecting, detecting and monitoring.

公开(公告)号：WO2021048645A1

公开(公告)日：2021-03-18

申请号：PCT/IB2020/056480

申请日：2020-07-09

Applicant: UNIVERSIDADE DO PORTO ,  UNIVERSIDADE NOVA DE LISBOA

Inventor： PEIXE, Luísa ,  LEDO, Filipa ,  REIS, Maria ,  TORRES, Cristiana

IPC: C12P7/22 ,  C12P7/40 ,  C12R1/01

Abstract: The present invention relates to a process of naturally producing 2-PE by using Acinetobacter soli bacterium. For this purpose, A. soli strains selected from environmental isolates were cultured in a bioreactor under average fermentation conditions. A. soli strain ANG 344B (Accession Number 1593) is particularly able to improve the production of 2-PE resulting in high yields of said compound. This compound is responsible for the scent of roses having a high commercial price when compared with the synthetically produced compound. It can be used in food, cosmetic and pharmaceutical sectors as organoleptic enhancer, antibacterial and antifungal agent. Moreover, 2-PE is also a valuable alcohol that can be used as a next generation biofuel, and as a raw material for its derivatives in pharmaceutical and fine chemical industries. Therefore, the present invention is in the field of microbiology, chemistry and biotechnology and has application in the food, cosmetic, pharmaceutical and fuel industries.

公开(公告)号：WO2020070700A4

公开(公告)日：2020-04-09

申请号：PCT/IB2019/058462

申请日：2019-10-04

Applicant: EXOGENUS THERAPEUTICS, SA

Inventor： CORREIA, Joana ,  CARDOSO, Renato ,  RODRIGUES, Sílvia

IPC: A61K35/51

Abstract: The present invention relates to a process for isolating Small Extracellular Vesicles secreted by umbilical cord blood mononuclear cells (UCBMNCs) and compositions comprising said Small Extracellular Vesicles, which are useful to be applied to autoimmune diseases therapeutics or prophylactics and/or cosmetic purposes. The proposed process for isolating UCBMNCs Small Extracellular Vesicles comprises three main steps: i) a first step of sequential centrifugation, ii) a second step of microfiltration combined with ultrafiltration (UF), and iii) a third step of size exclusion chromatography (SEC) and aims to achieve highly pure Small Extracellular Vesicles and in a higher yield. The SEVs compositions comprise specific type of proteins, RNA and lipids, that enables them to be very effective when applied to inflammatory and autoimmune diseases therapeutics, such as psoriasis, lupus, atopic dermatitis, eczema, etc. and also to cosmetic or prophylactic compositions. Therefore, the present invention lays in the technical domain of pharmaceuticals, medicine, cosmetics, research and development in cellular biology and appliances thereof.

公开(公告)号：WO2019215564A1

公开(公告)日：2019-11-14

申请号：PCT/IB2019/053665

申请日：2019-05-06

Applicant: ANTUNES, Nuno

Inventor： ANTUNES, Nuno

IPC: A41D15/00 ,  A41D13/12 ,  A41D13/00

Abstract: The present invention is related to a textile article developed to be used as a way to warm up healthcare professionals, said article being in the form of a jacket with pockets and removable sleeves. This jacket has the particularity of being functional not only in terms of warming up the user, but also for allowing to store small personal and/or professional objects and, simultaneously, fulfilling the requirements of asepsis and sterilization imposed to the healthcare professionals. Therefore, the present invention belongs to the area of protective clothing for professional use, particularly to be used by healthcare professionals, preferentially in a hospital setting.