公开(公告)号：WO2020037299A1

公开(公告)日：2020-02-20

申请号：PCT/US2019/046963

申请日：2019-08-16

Applicant: OHKI, Akiyoshi ,  RICH, Whitney

Inventor： OHKI, Akiyoshi ,  RICH, Whitney

IPC: C02F1/78 ,  C02F103/00 ,  C02F1/72

Abstract: The efficiency of water disinfection can be significantly increased by supplying the ozone in combination with oxygen (16) to an inlet of a cavitation pump (14). The ozone and the oxygen (16) are turned into ultra-fine bubbles (22) via cavitation action within the pump (14), facilitating the dissolution of the oxygen and ozone within the water (11). The water (11) mixed with the oxygen and the ozone (16) is supplied to a line atomizer (20), where the dissolution of the ozone within the mixture is completed. The combined use of the cavitation pump (14) and the line atomizer (20) can lead to a substantially complete dissolution of the supplied ozone within water (11) that needs to be disinfected, allowing to achieve the concentration of ozone necessary for disinfection. The system (10) and method (30) described are highly scalable and suitable for water purification at water purification plants of various sizes.

公开(公告)号：WO2016164623A1

公开(公告)日：2016-10-13

申请号：PCT/US2016/026502

申请日：2016-04-07

Applicant: BARDY DIAGNOSTICS, INC.

Inventor： FELIX, Jason ,  BISHAY, Jon Mikalson ,  BARDY, Gust H.

IPC: A61B5/0432 ,  A61B5/11 ,  A61B5/00 ,  A61B5/04 ,  G01N27/30

CPC classification number: A61B5/04085 ,  A61B5/0006 ,  A61B5/0022 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/04017 ,  A61B5/04087 ,  A61B5/04325 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/0816 ,  A61B5/087 ,  A61B5/091 ,  A61B5/1116 ,  A61B5/1117 ,  A61B5/1118 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/14551 ,  A61B5/4809 ,  A61B5/6801 ,  A61B5/6823 ,  A61B5/6833 ,  A61B5/7455 ,  A61B2505/07 ,  A61B2560/0271 ,  A61B2560/0412 ,  A61B2560/045 ,  A61B2562/0219 ,  A61B2562/164 ,  G01N27/307

Abstract: Physiological monitoring can be provided through a syncope sensor (64, 66) embedded into an electrocardiography monitor (12), which correlates syncope events and electrocardiographic data. Physiological monitoring can be provided through a lightweight wearable monitor (12) that includes two components: a flexible extended-wear electrode patch (15) and a reusable monitor recorder (14) that removably snaps into a receptacle (25) on the electrode patch (15). The wearable monitor (12) sits centrally on the patient's sternal midline (16) and includes a unique narrow "hourglass"-like shape, significantly improving the ability of the monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and QRS interval signals. The electrocardiographic electrodes (38, 39) on the electrode patch (15) are tailored for axial positioning along the midline (16) of the sternum (13) to capture action potential propagation in an orientation that corresponds to the aVF lead in a conventional 12-lead electrocardiogram, which senses positive P-waves (271).

Abstract translation: 可以通过嵌入心电图监视器（12）中的晕厥传感器（64,66）来提供生理监测，其将晕厥事件和心电图数据相关联。 可以通过包括两个部件的轻量级可穿戴式监视器（12）来提供生理监测：柔性延伸耐磨电极贴片（15）和可重复使用的监视器记录器（14），其可拆卸地卡入电极贴片上的插座（25） 15）。 可穿戴式监视器（12）位于患者胸骨中线（16）的中心，并且包括独特的窄的“沙漏”状形状，显着提高了监护仪的心脏电位信号特别是P波和QRS的能力 间隔信号 电极贴片（15）上的心电图电极（38,39）被定制成沿着胸骨（13）的中线（16）进行轴向定位，以捕获在常规12中对应于aVF引线的取向中的动作电位传播 - 心电图检测正P波（271）。

公开(公告)号：WO2021225616A1

公开(公告)日：2021-11-11

申请号：PCT/US2020/047688

申请日：2020-08-24

Applicant: CNA MANUFACTURING SYSTEMS, INC.

Inventor： COOK, Larry Ray ,  STAMEN, Justin Somers ,  MILLER, Brian Lee ,  MASON, Steven Heath ,  KELLY, Kenneth O'Neil

IPC: B23Q1/03

Abstract: The low profile of the flexible tooling system (100) disclosed allows for flexible tooling to be added to nearly all CNC machines with an accommodating z-axis height and allows easier relocation of the system (100) from one CNC machine to another. The system includes one or more pods (2), each of the pods (2) of the system (100) replacing the function of four independent actuators of earlier systems but operating with a shared mechanical frame. Arranging the mechanism into groups of four allows for greater density of part support spacing, minimizes cable requirements, and allows for air (102), vacuum (103), and vacuum sensor (20) requirements be localized on each pod. The pods allow for part supports to be spaced as close as 6" in the x and y axis. An increased variable position assembly density allows for greater flexibility to hold complicated parts.

公开(公告)号：WO2015048323A3

公开(公告)日：2015-04-02

申请号：PCT/US2014/057511

申请日：2014-09-25

Applicant: BARDY DIAGNOSTICS, INC.

Inventor： FELIX, Jason ,  BISHAY, Jon Mikalson ,  BARDY, Gust H.

IPC: A61B5/0402 ,  A61B5/0408 ,  A61B5/00 ,  A61B5/0428 ,  H01M4/74

Abstract: Physiological monitoring can be provided through a wearable monitor (12) that includes a flexible extended wear electrode patch (15) and a removable reusable monitor recorder (14). A pair of flexile wires (61, 71) is interlaced or sewn into a flexible backing (20), serving as electrode signal pickup and electrode circuit traces. The monitor (12) sits centrally on the patient's chest along the sternum (13), which significantly improves the ability to sense cutaneously cardiac electric signals, particularly those generated by the atrium. To counter the dislodgment due to compressional and torsional forces, non-irritating adhesive (43) is provided on the underside, or contact, surface of the electrode patch (15), but only on the distal (30) and proximal ends (31). Interlacing the flexile wires (61, 71) into the flexile backing (20) also provides structural support and malleability against compressional, tensile and torsional forces.

公开(公告)号：WO2015048194A1

公开(公告)日：2015-04-02

申请号：PCT/US2014/057308

申请日：2014-09-24

Applicant: BARDY DIAGNOSTICS, INC.

Inventor： BARDY, Gust H. ,  BISHAY, Jon Mikalson ,  FELIX, Jason

IPC: A61B5/00 ,  A61B5/0402

CPC classification number: A61B5/4818 ,  A61B5/0402 ,  A61B5/6833

Abstract: Physiological monitoring can be provided through a wearable monitor (12, 180) that includes two components, a flexible extended wear electrode patch (15, 181) and a removable reusable monitor recorder (14). The monitor (12) sits centrally (in the midline (16)) on the patient's chest along the sternum (13) oriented top-to-bottom. The placement of the monitor (12) in a location at the sternal midline (16) (or immediately to either side of the sternum (13)) benefits extended wear by removing the requirement that ECG electrodes be continually placed in the same spots throughout the monitoring. Instead, the patient can place an electrode patch (15) anywhere within the general region of the sternum (13). Power is provided through a battery (71, 197) provided on the patch (15, 181). The monitor (12, 180) further includes sensors (42, 69, 75, 191-195) for monitoring patient's air flow and respiratory measures contemporaneously with the ECG monitoring.

Abstract translation: 可以通过包括两个部件的可穿戴式监视器（12,180），柔性延长的耐磨电极贴片（15,181）和可拆卸的可重复使用的监视记录器（14）来提供生理监视。 监视器（12）位于患者胸部沿着胸骨（13）的中心（在中线（16））中心（顶部到底部）。 将监护仪（12）放置在胸骨中线（16）（或立即位于胸骨（13）的任一侧）的位置，通过消除将ECG电极连续放置在整个相同点上的要求而有益于延长的磨损 监控。 相反，患者可以将电极贴片（15）放置在胸骨（13）的一般区域内的任何位置。 通过设置在贴片（15,181）上的电池（71,197）提供电力。 监测器（12,180）还包括用于监测患者的气流和与ECG监测同时的呼吸测量的传感器（42,69,75,191-195）。

公开(公告)号：WO2015048191A1

公开(公告)日：2015-04-02

申请号：PCT/US2014/057305

申请日：2014-09-24

Applicant: BARDY DIAGNOSTICS, INC.

Inventor： BARDY, Gust H. ,  FELIX, Jason ,  BISHAY, Jon Mikalson

IPC: A61B5/0402 ,  A61B5/11

CPC classification number: A61B5/1118 ,  A61B5/0402 ,  A61B5/1117 ,  A61B5/6833

Abstract: Physiological monitoring can be provided through an actigraphy sensor (64) imbedded into an electrocardiography monitor (12), which correlates movement and electrocardiographic data. Physiological monitoring can be provided through a wearable monitor (12) that includes two components, a flexible extended wear electrode patch (15) and a removable reusable monitor recorder (14). The monitor (12) sits centrally on the patient's chest along the sternum (13). The patient can place a patch (15) anywhere within the general region of the sternum (13). The occurrence of actigraphy events are monitored by the recorder (14) through an actigraphy sensor (64). Actigraphy becomes a recordable actigraphy event occurrence when the movement of the monitor (12) and, therefore, the patient (10, 11), exceeds a criteria threshold of acceleration or deceleration as detected by the actigraphy sensor (64). Certain actigraphy event occurrences are considered actionable, of sufficient importance to warrant flagging for further consideration to a following physician.

Abstract translation: 生理监测可以通过嵌入到心电图监测器（12）中的动力学传感器（64）来提供，其将运动和心电图数据相关联。 可以通过包括两个组件的可穿戴式监视器（12），柔性扩展耐磨电极贴片（15）和可拆卸的可重复使用的监视记录器（14）来提供生理监测。 显示器（12）沿着胸骨（13）位于患者胸部的中央。 患者可以在胸骨（13）的一般区域内的任何位置放置补片（15）。 通过记录仪（14）通过一个动力学传感器（64）监测动作事件的发生。 当监视器（12）的运动，因此病人（10,11）的运动超过由该法术传感器（64）检测到的加速或减速的标准阈值时，动画将成为可记录的动作事件发生。 某些活动事件发生被认为是可行的，具有足够的重要性，需要标记以便进一步考虑到下列医师。

公开(公告)号：WO2019204500A1

公开(公告)日：2019-10-24

申请号：PCT/US2019/027950

申请日：2019-04-17

Applicant: OHKI, Akiyoshi ,  CHIBA, Kousuke ,  RICH, Whitney

Inventor： OHKI, Akiyoshi ,  CHIBA, Kousuke ,  RICH, Whitney

IPC: C02F3/00 ,  C02F3/12 ,  C02F1/36 ,  C02F1/74 ,  C02F1/78

Abstract: Control over the wastewater purification can be achieved through controlling delivery of gas-dispersion return sludge solely (36) to an aerobic reaction vessel (16). The gas-dispersion return sludge (36) is created using pure oxygen or oxygen containing trace amounts of ozone as a reactive gas (37), which is blended with return sludge (35) to create a gas-liquid mixture, which is pressurized with an atomizer pump (22), and then at a pressure of not more than approximately 5.5 MPa, the mixture is passed through an atomizer (24) which uses cavitation or ultrasound at a frequency of less than 12,000 KHz to instantly render the reactive gas in the mixture to an ultra-fine bubble state. A portion of the gas is placed into a dissolved state, reaching a state of supersaturation with a high DO value of 20 - 40 mg/l, and causing the remaining ultra-fine bubbles to create an ultra-fine bubble condition

公开(公告)号：WO2016145392A1

公开(公告)日：2016-09-15

申请号：PCT/US2016/022154

申请日：2016-03-11

Applicant: BARDY DIAGNOSTICS, INC.

Inventor： BARDY, Gust H. ,  DREISBACH, Ezra M.

IPC: A61B5/0245 ,  A61B5/044 ,  A61B5/024 ,  A61B5/046

CPC classification number: A61B5/044 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/046

Abstract: R-R interval data is presented (24) in a format that includes relevant near field and far field ECG data. The near field view (51) provides a "pinpoint" classical view at classical recording speed. The far field view (52) provides an "intermediate" lower resolution, pre- and post-event view. Both ECG data views (51, 52) are temporally keyed to the extended duration R-R interval data (53) that is scaled non-linearly to maximize the visual differentiation for frequently-occurring heart rate ranges. The views (51, 52, 53) are presented simultaneously and their durations are flexible and adjustable. Diagnostically relevant cardiac events can be identified (23) and located to allow pre- and post-event heart rhythm data. The pinpoint "snapshot" and intermediate views of ECG data (56, 166) with the extended term R-R interval data (53) comparatively depicts heart rate context and patterns of behavior prior to and after a clinically meaningful arrhythmia or patient concern.

Abstract translation: 以包括相关近场和远场ECG数据的格式呈现R-R间隔数据（24）。 近场视图（51）以古典录制速度提供了“精准”古典景观。 远场视图（52）提供了“中间”较低分辨率，事件前和事件后视图。 两个ECG数据视图（51,52）在时间上键入到非线性缩放的扩展持续时间R-R间隔数据（53），以最大化频繁出现的心率范围的视觉差异。 视图（51,52,53）同时呈现，其持续时间灵活可调。 诊断相关的心脏事件可以被识别（23）并定位以允许事件前和事件后心律数据。 具有扩展术语R-R间隔数据（53）的ECG数据（56,166）的精确“快照”和中间视图比较地描绘了在临床上有意义的心律失常或患者关注之前和之后的心率上下文和行为模式。

公开(公告)号：WO2015048320A1

公开(公告)日：2015-04-02

申请号：PCT/US2014/057505

申请日：2014-09-25

Applicant: BARDY DIAGNOSTICS, INC.

Inventor： BARDY, Gust H. ,  FELIX, Jason ,  BISHAY, Jon Mikalson

IPC: A61B5/00 ,  A61B5/024

CPC classification number: A61B5/0022 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/7282 ,  G06F19/00 ,  G06F19/3418

Abstract: Physiological monitoring can be provided through a wearable monitor (12) that includes two components, a flexible extended wear electrode patch (15) and a removable reusable monitor recorder (14). The placement of the monitor (12) in a location at the sternal midline (16) (or immediately to either side of the sternum) benefits extended wear by removing the requirement that ECG electrodes be continually placed in the same spots throughout the monitoring. The monitor (12) can interoperate wirelessly with other physiology and activity sensors (131) and mobile devices (132). An application (132) executed by the sensor (131) or device (133) can trigger the dispatch of a wearable monitor (12) to the patient upon detecting potentially medically-significant events. The monitor (12) would then be capable of providing precise medically-actionable data. The patient (10, 11) can then use the sensor (131) or device (133) to record the placement and use of the monitor (12).

Abstract translation: 可以通过包括两个组件的可穿戴式监视器（12），柔性扩展耐磨电极贴片（15）和可拆卸的可重复使用的监视记录器（14）来提供生理监测。 将监护仪（12）放置在胸骨中线（16）（或立即位于胸骨两侧）的位置，可以通过消除在整个监测过程中将ECG电极连续放置在同一点上的要求，从而延长了磨损。 监视器（12）可以与其他生理和活动传感器（131）和移动设备（132）进行无线互操作。 由传感器（131）或设备（133）执行的应用程序（132）可以在检测潜在的医疗重要事件时触发对患者的可佩戴监视器（12）的调度。 监视器（12）将能够提供精确的医疗操作数据。 然后，患者（10,11）可以使用传感器（131）或设备（133）来记录监视器（12）的放置和使用。

公开(公告)号：WO2015048309A1

公开(公告)日：2015-04-02

申请号：PCT/US2014/057488

申请日：2014-09-25

Applicant: BARDY DIAGNOSTICS, INC.

Inventor： FELIX, Jason ,  BARDY, Gust H. ,  BISHAY, Jon Mikalson

IPC: A61B5/0402

CPC classification number: A61B5/04087 ,  A61B5/0006 ,  A61B5/0022 ,  A61B5/0402 ,  A61B5/04085 ,  A61B5/04325 ,  A61B5/6823 ,  A61B2562/08

Abstract: Physiological monitoring can be provided through a wearable monitor (12) that includes two components, a flexible extended wear electrode patch (15) and a removable reusable monitor recorder (14). The monitor (12) sits centrally (in the midline (16)) on the patient's chest along the sternum (13) oriented top-to-bottom. The placement of the monitor (12) in a location at the sternal midline (16) or immediately to either side of the sternum (13)) benefits extended wear by removing the requirement that ECG electrodes be continually placed in the same spots throughout the monitoring. Instead, the patient can place a patch (15) anywhere within the general region of the sternum (13). Ensuring that the quality of ECG recording remains constant over an extended period is provided through self-authentication of patches (15). The recorder (14) implements a challenge response scheme upon being connected to a patch (15). Failing self-authentication, the recorder (14) signals an error.

Abstract translation: 可以通过包括两个部件的可穿戴式监视器（12），柔性扩展耐磨电极贴片（15）和可拆卸的可重复使用的监视记录器（14）来提供生理监视。 监视器（12）位于患者胸部沿着胸骨（13）的中心（在中线（16））中心（顶部到底部）。 将监视器（12）放置在胸骨中线（16）或立即到胸骨（13）的任一侧的位置中，通过消除ECG电极在整个监视中连续放置在相同点上的要求而有益于延长的磨损 。 相反，患者可以在胸骨（13）的一般区域内的任何地方放置贴片（15）。 通过补片的自我认证来确保ECG记录的质量在一段较长的时间内保持不变（15）。 记录器（14）在连接到补丁（15）时实施挑战响应方案。 无法自我认证，记录仪（14）发出错误信号。