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公开(公告)号：WO2023083964A1
公开(公告)日：2023-05-19
申请号：PCT/EP2022/081473
申请日：2022-11-10
Applicant: 2A PHARMA AB
Inventor： BRUUN-NYZELL, Preben , PRANGSGAARD, Jeanette
IPC: A61K39/12 , A61P31/20 , A61P35/00 , C07K16/00 , C07K14/005
Abstract: The present invention relates to a mutated parvovirus structural protein, comprising at least one insertion comprising a sequence of amino acids from amino acids from HPV16 and/or HPV31 L2 protein for use in the treatment or prevention of a beta-type or gamma-type HPV infection. Furthermore, the invention relates to multimeric structures comprising the protein, VLPs, a method of producing the mutated parvovirus structural protein and to medicaments or vaccines comprising the mutated parvovirus structural protein that may be used for treating a beta-type or gamma-type HPV infection.
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2.发明申请
公开(公告)号：WO2023079166A1
公开(公告)日：2023-05-11
申请号：PCT/EP2022/081098
申请日：2022-11-08
Applicant: OMYA INTERNATIONAL AG
Inventor： BARADEL, Franck , WELKER, Matthias , BARANGER, Joris
Abstract: A polycarbonate composition is provided comprising a) a polycarbonate resin, b) a surface-treated calcium carbonate-containing material, wherein the surface-treated calcium carbonate-containing material is obtained by surface-treating a calcium carbonate-containing material with at least one hydrophobizing agent selected from the group consisting of aliphatic-substituted succinic anhydrides, carboxylic acid- and/or anhydride-functional polysiloxanes, and mixtures thereof, c) optionally titanium dioxide, d) optionally one or more additives. A use is provided of a surface-treated calcium carbonate-containing material as defined in the application as a filler for a polycarbonate composition. A surface-treated calcium carbonate-containing material is provided, wherein the surface-treated calcium carbonate-containing material is obtained by surface-treating a calcium carbonate-containing material with at least one hydrophobizing agent selected from the group consisting of carboxylic acid- and/or anhydride-functional polysiloxanes.
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公开(公告)号：WO2023079058A1
公开(公告)日：2023-05-11
申请号：PCT/EP2022/080777
申请日：2022-11-04
Applicant: YOKOGAWA INSILICO BIOTECHNOLOGY GMBH
Inventor： NARGUND, Shilpa , MAUCH, Klaus
Abstract: The present invention relates to cell culture methods and compositions thereof that in one aspect improve the yield and quality of a biologic. The cell culture methods include expressing a polynucleotide of interest to improve the yield and quality of a biologic produced in a mammalian cell culture. In one aspect, a method for the production of a biologic of interest in a cell population, the method comprising providing a cell population expressing a polynucleotide; providing conditions to allow for the production of a biologic of interest in the cell population; wherein the polynucleotide is selected from the group consisting of a polynucleotide encoding a transporter of aspartate across the cell membrane, a polynucleotide encoding a protein involved in biosynthesis of aspartate, or any combination thereof, wherein expressing the polynucleotide results in an increased amount of aspartate in the cell when compared to a cell population that does not express the polynucleotide, wherein the increased amount of aspartate reduces the production of lactate in the cell population, thereby providing a method for the production of a biologic of interest in the cell population.
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公开(公告)号：WO2023072798A1
公开(公告)日：2023-05-04
申请号：PCT/EP2022/079516
申请日：2022-10-24
Applicant: BASF SE
Inventor： STAAL, Maarten , SCHMID, Markus , PASDA, Gregor , THIEL, Uwe , MALANG, Ulrike , KNAUER, Manuel
Abstract: The present invention relates to a solid composition (1) comprising (A) a mixture comprising N-(n-butyl)thiophosphoric acid triamide (NBPT) and optionally N-(n-propyl)thiophosphoric acid triamide (NPPT); (B) a solvent selected from the group consisting of glycol ether, glycerin ether, and mixtures thereof; and (C) urea, wherein the solid composition (1) is polymer free. Further, the present invention relates to the use of a solvent selected from the group consisting of glycol ether, glycerin ether, C3-C10-alkanediol, carboxylic acid amide, and mixtures thereof for stabilizing at least one (thio)phosphoric acid triamide in a solid composition (1) comprising a mixture (A) comprising the at least one (thio)phosphoric acid triamide, urea, and the solvent.
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公开(公告)号：WO2023062108A1
公开(公告)日：2023-04-20
申请号：PCT/EP2022/078455
申请日：2022-10-13
Applicant: BOREALIS AG
Inventor： JAYARATNE, Kumudini , RÖNKKÖ, Hanna-Leena , SHUTOV, Pavel , KETTNER, Joana Elvira , PARJANEN, Jukka-Pekka , TIITINEN, Emilia
IPC: C08F110/06 , C07F7/28
Abstract: A process for forming a Ziegler-Natta catalyst component, wherein a certain combination of washing steps is employed, enabling the provision of inventive catalysts capable of synthesising polypropylenes with increased melting temperature, decreased XCS content, as well as more efficiently maintaining catalyst activity across sequential polymerization processes.
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Patent Agency Ranking
公开(公告)号：WO2023046295A1
公开(公告)日：2023-03-30
申请号：PCT/EP2021/076397
申请日：2021-09-24
Applicant: ABB SCHWEIZ AG , TERPSTRA, Haayo
Inventor： TERPSTRA, Haayo
Abstract: An end effector (22) for a fruit picking robot has a distal portion comprising tools for seizing and detaching a fruit (3) from its mother plant, a proximal portion comprising an interface for mounting the end effector (22) to a robot arm, and a storage bay (30) for picked fruit (3). The storage bay (30) is elongate in a longitudinal direction and has a discharge port (40) extending along the full length of the storage bay (30) in the longitudinal direction (24). A fruit support member (37) has a longitudinally extending edge (39) which delimits the discharge port (40).
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7.发明申请
公开(公告)号：WO2023036749A1
公开(公告)日：2023-03-16
申请号：PCT/EP2022/074670
申请日：2022-09-06
Applicant: BASF SE
Inventor： SOHN, Myriam , SCHNYDER, Marcel , KRUS, Stanislaw
Abstract: The present application relates to a sunscreen or daily care composition comprising bis- ethylhexyloxyphenol methoxyphenyl triazine (INCI bis-ethylhexyloxyphenol methoxyphenyl triazine), titanium dioxide, and zinc oxide.
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8.发明申请
公开(公告)号：WO2023031241A1
公开(公告)日：2023-03-09
申请号：PCT/EP2022/074146
申请日：2022-08-31
Applicant: BOREALIS AG
Inventor： WANG, Jingbo , GAHLEITNER, Markus , BERNREITNER, Klaus , LESKINEN, Pauli
IPC: C08L23/14
Abstract: A monophasic polypropylene composition (PC), having a melt flow rate (MFR2) of 1.0 to 50.0 g/10 min, comprising: a) 55.0 to 95.0 wt.-% of a random copolymer of propylene (R-PP) having an MFR2 of 1.0 to 30.0 g/10 min, a comonomer content of 0.5 to 6.0 mol-%, and a content of 2,1-regiodefects of 0.1 to 1.4 mol-%; and b) 5.0 to 45.0 wt.-% of a propylene homopolymer composition (H-PP), comprising a reactor blend of a propylene homopolymer and a polymeric nucleating agent that is present in an amount of 20 to 300 wt-ppm, wherein the propylene homopolymer composition (H-PP) has an MFR2 of 10 to 100 g/10 min and is free from 2,1-regiodefects; wherein the combined weight of the random copolymer of propylene (R-PP) and the propylene homopolymer composition (H-PP) is at least 95 wt.-%.
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公开(公告)号：WO2023020930A1
公开(公告)日：2023-02-23
申请号：PCT/EP2022/072542
申请日：2022-08-11
Applicant: MEDICAL UNIVERSITY OF GRAZ , KING'S COLLEGE LONDON , NUMERICOR GMBH
Inventor： PLANK, Gernot , BISHOP, Martin , NEIC, Aurel , CAMPOS, Fernando
Abstract: A computer-implemented method of determining one or more target sites (200) usable for treatment of ventricular tachycardia is proposed. The method comprises receiving, with a computing device (100) including one or more processors (110), three-dimensional model data indicative of a cardiac model (150) modelling an anatomy of a heart of a subject with fibrosis, wherein the cardiac model (150) includes at least one myocardial segment (160) associated with and/or modelled as electrically conducting myocardial tissue and at least one fibrotic segment (170) associated with and/or modelled as insulating fibrotic tissue. The method further comprises simulating (S1) the evolution of a cardiac activation wave across the at least one myocardial segment (160) and the at least one fibrotic segment (170), and determining (S2) at least one split location (182), at which an isosurface (180) of the simulated wave is split into two or more sections (18a-c), the at least one split location (182) being indicative of a location for the simulated wave hitting a boundary between the at least one fibrotic segment (170) and the at least one myocardial segment (160). The method further comprises determining one or more target sites (200) based on the determined at least one split location (182).
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10.发明申请
公开(公告)号：WO2023016651A1
公开(公告)日：2023-02-16
申请号：PCT/EP2021/072537
申请日：2021-08-12
Applicant: AZYRO SA
Inventor： VANCRAEYENEST, Marc
Abstract: The present invention provides a method, device and/or system, and computer program element for providing an electrical signal in correspondence with a resonant frequency range of genetic material by a medical treatment device. The method comprises receiving (S310), by a processor (120, 121), length information data associated with a wavelength of the genetic material. The method further comprises determining (S320), by the processor (120, 121), a basic resonant frequency of the genetic material by dividing a velocity through a tissue or medium surrounding the genetic material by the wavelength of the genetic material. Further, the method comprises performing (S330), by the processor (120, 121), a multi-stage shift on the basic resonant frequency to an operable frequency range that can be output by the medical treatment device by applying multiple multiplication or division operations on the basic resonant frequency using a number of factors different to each other to obtain one or more shifted resonant frequencies determined to be in the operable frequency range. And the method comprises generating (S340) a driver signal for providing the electrical signal based on the one or more shifted resonant frequencies determined to be in the operable frequency range.
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