公开(公告)号：WO2021067948A1

公开(公告)日：2021-04-08

申请号：PCT/US2020/054286

申请日：2020-10-05

Applicant: JAVELIN BIOTECH, INC.

Inventor： CIRIT, Murat ,  ALAYBEYOGLU, Begum ,  SHERFEY, Jason Samuel ,  RUMSEY, John Wayne ,  SHIN, Yoojin

IPC: B01L3/00 ,  G01N33/50

Abstract: A microphysiological system (MPS) includes at least one first inlet for receiving a fluid medium. The MPS includes a brain module comprising brain tissue. The MPS includes a blood-brain-barrier (BBB) module comprising BBB tissue, the BBB module configured to receive the fluid medium. The MPS includes a crosstalk channel between the brain module and the BBB module, the crosstalk channel configured to promote a bidirectional crosstalk between the brain tissue and the BBB tissue in response to receiving the fluid medium at the BBB module. The MPS is configured for treating the brain tissue and the BBB tissue with a drug or a combination of drugs to determine a phenotypic effect and a transcriptomic effect of the drug. A drug perturbation is related to the phenotypic effect and the transcriptomic effect based on kinetic optimization.

公开(公告)号：WO2018187595A1

公开(公告)日：2018-10-11

申请号：PCT/US2018/026293

申请日：2018-04-05

Applicant: HUDSON, Andrew ,  HINTON, Thomas ,  FEINBERG, Adam ,  LEE, Andrew

Inventor： HUDSON, Andrew ,  HINTON, Thomas ,  FEINBERG, Adam ,  LEE, Andrew

IPC: B01J13/06 ,  B01J13/08 ,  B01J13/10 ,  A61K9/107 ,  A61K9/16 ,  A61K9/50 ,  A61L27/14 ,  A61L27/20 ,  A61L27/24 ,  A61L27/52

Abstract: This document describes a process of producing gel microparticles, which are consistent in size and morphology. Through the process of coacervation, large volumes of gel microparticle slurry can be produced by scaling up reactor vessel size. Particles can be repeatedly dehydrated and rehydrated in accordance to their environment, allowing for the storage of particles in a non-solvent such as ethanol. Gel slurries exhibit a Bingham plastic behavior in which the slurry behaves as a solid at shear stresses that are below a critical value. Upon reaching the critical shear stress, the slurry undergoes a rapid decrease in viscosity and behaves as a liquid. The rheological behavior of these slurries can be adjusted by changing the compaction processes such as centrifugation force to alter the yield-stress. The narrower distribution and reduced size of these particles allows for an increase in FRESH printing fidelity.

公开(公告)号：WO2018067613A1

公开(公告)日：2018-04-12

申请号：PCT/US2017/054999

申请日：2017-10-03

Applicant: HARRISON, Christopher

Inventor： HARRISON, Christopher ,  ZHANG, Yang ,  LAPUT, Gierad

IPC: B25J9/16 ,  G08B21/00 ,  H04B7/00

Abstract: A method for a touch sensing system includes generating, by a first pair of electrodes at a first location in a conductive material, an electric field in the conductive material; generating measurement data by measuring, by one or more second pairs of electrodes, the electric field in the conductive material at one or more second locations in the conductive material, with each of the one or more second locations differing from the first location; generating, based on the measurement data, an approximation of the electric field in the conductive material; and classifying, based on the approximation, one or more regions of the interface into a given state.

Abstract translation: 一种用于触摸感测系统的方法，包括：由导电材料中的第一位置处的第一对电极产生所述导电材料中的电场; 通过由一个或多个第二对电极测量在所述导电材料中的一个或多个第二位置处的所述导电材料中的电场来生成测量数据，其中所述一个或多个第二位置中的每一个不同于所述第一位置; 基于测量数据生成导电材料中的电场的近似值; 并基于该近似将接口的一个或多个区域分类为给定状态。

公开(公告)号：WO2018035486A1

公开(公告)日：2018-02-22

申请号：PCT/US2017/047658

申请日：2017-08-18

Applicant: VESPER TECHNOLOGIES INC.

Inventor： LITTRELL, Robert J.

IPC: H04R17/02

Abstract: A piezoelectric, acoustic device comprising: a substrate; a plurality of plates, each plate comprising a first electrode layer, a piezoelectric layer and a second electrode layer, wherein the piezoelectric layer is in between the first electrode layer and the second electrode layer, and wherein, for each plate, a base of the plate is affixed to the substrate and a remaining portion of the plate is unaffixed to the substrate; and a plate coupling structure affixed to a first one of the plates and to a second one of the plates, wherein the plate coupling structure at least partly covers a gap between a first edge of the first one of the plates and a second edge of the second one of the plates, wherein the first edge faces the second edge; wherein the plate coupling structure comprises a mismatch reduction element and a stopping element, wherein the mismatch reduction element is configured to reduce an amount of mismatch in deflection of the first one of the plates and the second one of the plates, and wherein the stopping element is configured to enable the mismatch reduction element to expand only up to a specified amount.

Abstract translation: 一种压电声学装置，包括：基板; 多个板，每个板包括第一电极层，压电层和第二电极层，其中压电层位于第一电极层和第二电极层之间，并且其中对于每个板， 将板固定到基底上，并将板的其余部分不固定到基底上; 以及板联接结构，所述板联接结构固定到所述板中的第一板和所述板中的第二板，其中所述板联接结构至少部分地覆盖所述板中的所述第一板的第一边缘与所述板中的第二边缘 第二个板，其中第一边缘面对第二边缘; 其中，所述板联接结构包括失配减少元件和止动元件，其中，所述失配减少元件构造成减小所述板中的所述第一板和所述板中的所述第二板的偏转量，并且其中，所述止动元件 被配置为使失配减少元件仅扩展到指定量。

公开(公告)号：WO2017087928A1

公开(公告)日：2017-05-26

申请号：PCT/US2016/063007

申请日：2016-11-21

Applicant: VESPER TECHNOLOGIES INC.

Inventor： LITRELL, Robert J.

IPC: H04R19/04 ,  H04R1/28

CPC classification number: H04R1/222 ,  H04R17/02 ,  H04R19/04 ,  H04R31/006 ,  H04R2499/11

Abstract: A package comprises: a transducer; a substrate comprising an acoustic port, with the transducer attached to a surface of the substrate and over or adjacent to the acoustic port; and a venting mechanism for venting air or sound pressure from a device comprising the package, with the venting mechanism being affixed to the substrate and partially surrounding the acoustic port, and with the venting mechanism being dimensioned to filter out audio frequencies.

Abstract translation: 包装包括：换能器; 包括声学端口的基底，其中所述换能器连接到所述基底的表面并且在所述声学端口上方或附近; 以及用于从包括包装的装置排出空气或声压的通气机构，其中通气机构固定到基底并且部分地围绕声学端口，并且通气机构的尺寸被设计为过滤掉音频。

公开(公告)号：WO2017070656A1

公开(公告)日：2017-04-27

申请号：PCT/US2016/058440

申请日：2016-10-24

Applicant: HAUPTMANN, Alexander G.

Inventor： HAUPTMANN, Alexander G. ,  JIANG, Lu ,  HUANG, Po-yao

IPC: G06F17/30

CPC classification number: G06F17/3079 ,  G06F17/30837

Abstract: This document describes a search retrieval system for automatically indexing data representing audio-visual recordings and for querying, responsive to a search query, that indexed data representing the audio-visual recordings. The search retrieval system defines weights for semantic features of an audio-visual recording and extracts, based on execution of a first set of rules, one or more semantic features. The system determines a weight for each of the one or more semantic features. A search engine searches nodes in the graph of the semantic features to identify one or more logical relationships for the one or more semantic features extracted. The weights for each of the one or more semantic features are adjusted based on the graph. The data is indexed in association with the one or more adjusted weights for the one or more semantic features, respectively.

Abstract translation: 该文件描述了一种搜索检索系统，用于自动索引表示视听记录的数据并用于响应于搜索查询而查询表示该视听记录的索引数据。 搜索检索系统定义视听记录的语义特征的权重，并且基于第一组规则的执行提取一个或多个语义特征。 系统为一个或多个语义特征中的每一个确定权重。 搜索引擎搜索语义特征的图中的节点以识别所提取的一个或多个语义特征的一个或多个逻辑关系。 基于该图来调整一个或多个语义特征中的每一个的权重。 数据分别与一个或多个语义特征的一个或多个调整权重相关联地索引。

公开(公告)号：WO2017049278A9

公开(公告)日：2017-03-23

申请号：PCT/US2016/052461

申请日：2016-09-19

Applicant: VESPER TECHNOLOGIES INC.

Inventor： LITTRELL, Robert J.

IPC: B81B3/00 ,  B81B7/00

Abstract: A transducer and method for processing a MEMS transducer. In one aspect, the MEMS transducer includes a first plate and a second plate. The MEMS transducer can also include a spring substantially between the first plate and the second plate, the spring including first and second spring arms dimensioned to decrease vertical deflection mismatch between the first and second plates, relative to vertical deflection mismatch of the first and second plates independent of the spring.

公开(公告)号：WO2017024164A1

公开(公告)日：2017-02-09

申请号：PCT/US2016/045612

申请日：2016-08-04

Applicant: AB INITIO TECHNOLOGY LLC

Inventor： WHOLEY, Joseph Skeffington ,  GADODIA, Rajesh

IPC: G06F17/30

CPC classification number: G06F17/30516 ,  G06F17/30398 ,  G06F17/30958

Abstract: A computer-implemented method for executing a query on data items located at different places in a stream of near real-time data to provide near-real time intermediate results for the query, as the query is being executed, the method including: from time to time, executing, by one or more computer systems, the query on two or more of the data items located at different places in the stream, with the two or more data items being accessed in near real-time with respect to each of the two or more data items; generating information indicative of results of executing the query; and as the query continues being executed, generating intermediate results of query execution by aggregating the results with prior results of executing the query on data items that previously appeared in the stream of near real-time data; and transmitting to one or more client devices the intermediate results of query execution, prior to completion of execution of the query.

Abstract translation: 一种计算机实现的方法，用于对位于近实时数据流中的不同位置的数据项执行查询，以便在执行查询时提供用于查询的近实时中间结果，所述方法包括：从时间 通过一个或多个计算机系统对位于流中不同位置的两个或多个数据项执行查询，其中两个或多个数据项相对于每个数据项被接近实时访问 两个或多个数据项; 产生指示执行查询结果的信息; 并且随着查询继续执行，通过将结果与先前在近实时数据流中出现的数据项执行查询的先前结果相结合来生成查询执行的中间结果; 以及在执行查询之前向一个或多个客户机设备发送查询执行的中间结果。

公开(公告)号：WO2015027070A1

公开(公告)日：2015-02-26

申请号：PCT/US2014/052110

申请日：2014-08-21

Applicant: CARNEGIE MELLON UNIVERSITY

Inventor： BHARGAVA, Mudit ,  MAI, Kenneth Wei-An

IPC: H04L9/32

CPC classification number: H03K19/00315 ,  G09C1/00 ,  H04L9/0866 ,  H04L9/3278 ,  H04L2209/12

Abstract: Techniques and circuits are disclosed for obtaining a physical unclonable function (PUF) circuit that is configured to provide, during a first operational mode, an output signal that is dependent on an electric characteristic of the PUF circuit. Techniques and circuits described herein can cause the PUF circuit to enter a second operational mode by applying a stress signal to the PUF circuit that changes a value of the electric characteristic relative to another value of the electric characteristic during the first operational mode of the PUF circuit; and adjusting, based on changing the absolute value of the first electric characteristic, a bias magnitude of the output signal relative to another bias magnitude of the output signal during the first operational mode of the PUF circuit.

Abstract translation: 公开了用于获得物理不可克隆功能（PUF）电路的技术和电路，其被配置为在第一操作模式期间提供取决于PUF电路的电特性的输出信号。 这里描述的技术和电路可以通过向PUF电路施加应力信号来使PUF电路进入第二操作模式，PUF电路在PUF电路的第一操作模式期间相对于电特性的另一值改变电特性值 ; 以及在PUF电路的第一操作模式期间，基于改变第一电特性的绝对值，调整输出信号相对于输出信号的另一偏置幅度的偏置幅度。

公开(公告)号：WO2014071165A1

公开(公告)日：2014-05-08

申请号：PCT/US2013/068018

申请日：2013-11-01

Applicant: GOOGLE INC.

Inventor： HAUGEN, Frances B. ,  MARRA, Gregory M.

IPC: G06Q50/00

CPC classification number: G06Q50/01

Abstract: A method performed by one or more processing devices includes receiving a request for social media content that is relevant to one or more search terms; identifying, based on a social graph of a user, social media content with connections in the social graph to the user, wherein the social media content is associated with metadata; identifying metadata that is associated with the identified social media content and that has at least a threshold amount of relevance to the one or more search terms; generating a summarization of contents of the metadata identified and contents of the social media content identified; and transmitting, to the device used by the user who sent the request, the summarization for presentation to the user, in response to the request for social media content.

Abstract translation: 由一个或多个处理设备执行的方法包括接收与一个或多个搜索词相关的社交媒体内容的请求; 基于所述用户的社交图来识别具有所述社交图中的所述用户的连接的社交媒体内容，其中所述社交媒体内容与元数据相关联; 识别与所识别的社交媒体内容相关联的元数据，并且具有至少一个与所述一个或多个搜索词语相关的阈值量; 生成所识别的元数据的内容和所识别的社交媒体内容的内容的总结; 以及响应于社交媒体内容的请求，向发送请求的用户使用的用于向用户呈现的摘要的发送。