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公开(公告)号：WO2011159924A3
公开(公告)日：2011-12-22
申请号：PCT/US2011/040742
申请日：2011-06-16
Applicant: TAXON BIOSCIENCES, INC. , ASHBY, Matthew , WOOD, Ladonna , LIDSTRÖM, Ulrika , CLARKE, Christine , GOULD, Alison , STRAPOC, Dariusz , LAMBO, Adewale , HUIZINGA, Bradley, James
Inventor： ASHBY, Matthew , WOOD, Ladonna , LIDSTRÖM, Ulrika , CLARKE, Christine , GOULD, Alison , STRAPOC, Dariusz , LAMBO, Adewale , HUIZINGA, Bradley, James
Abstract: This invention generally relates to natural gas and methylotrophic energy generation, bio-generated fuels and microbiology. In alternative embodiments, the invention provides nutrient amendments and microbial compositions, e.g., consortia, that are both specifically optimized to stimulate methanogenesis, or for "methylotrophic" or other conversions. In alternative embodiments, the invention provides methods to develop nutrient amendments and microbial compositions that are both specifically optimized to stimulate methanogenesis in a given reservoir. The invention also provides methods for the evaluation of potentially damaging biomass formation and scale precipitation resulting from the addition of nutrient amendments. In other embodiments, the invention provides methods for simulating biogas in sub-surface conditions using a computational model.
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2.发明申请METHODS FOR THE IDENTIFICATION OF REPORTER AND TARGET MOLECULES USING COMPREHENSIVE GENE EXPRESSION PROFILES 审中-公开使用综合基因表达谱鉴定报告物和目标分子的方法
公开(公告)号：WO0058521A2
公开(公告)日：2000-10-05
申请号：PCT/US0008604
申请日：2000-03-31
Applicant: ROSETTA INPHARMATICS INC , ASHBY MATTHEW , SCHERER STEWART , PHILLIPS JOHN , ZIMAN MICHAEL , MARINI NICHOLAS
Inventor： ASHBY MATTHEW , SCHERER STEWART , PHILLIPS JOHN , ZIMAN MICHAEL , MARINI NICHOLAS
Abstract: The present invention relates to methods of identifying genes whose expression is indicative of activation of a particular biochemical or metabolic pathway or a common set of biological reactions or functions in a cell ("regulon indicator genes"). The present invention provides an example of such an indicator gene. The present invention also relates to methods of partially characterizing a gene of unknown function by determining which biological pathways, reactions or functions its expression is associated with, thereby placing the gene within a functional genetic group or "regulon". These partially characterized genes may be used to identify desirable therapeutic targets of biological pathways of interest ("regulon target genes"). The present invention provides examples of such target genes. Methods for identifying effectors (activators and inhibitors) of regulon target genes are provided. The present invention also provides examples of regulon target gene inhibitors.
Abstract translation: 本发明涉及鉴定其表达指示特定生物化学或代谢途径的激活或细胞中的一组共同的生物反应或功能（“调节子指示基因”）的基因的方法。 本发明提供了这种指示基因的实例。 本发明还涉及通过确定哪些生物学途径，其表达与其相关的生物学途径，反应或功能来部分表征未知功能的基因，从而将基因置于功能性遗传组或“调节子”内的方法。 这些部分表征的基因可用于鉴定感兴趣的生物学途径的所需治疗靶标（“调节基因靶基因”）。 本发明提供了这些靶基因的实例。 提供了用于鉴定调节子靶基因的作用剂（活化剂和抑制剂）的方法。 本发明还提供了调节基因靶基因抑制剂的实例。
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3.发明申请
公开(公告)号：WO2012016215A3
公开(公告)日：2012-02-02
申请号：PCT/US2011/046015
申请日：2011-07-29
Applicant: TAXON BIOSCIENCES, INC. , ASHBY, Matthew , DIMSTER-DENK, Dago
Inventor： ASHBY, Matthew , DIMSTER-DENK, Dago
Abstract: In alternative embodiments, the invention provides products of manufacture and compositions, e.g., nucleic acid probes, for use as identifying agents or indicators to detect the presence of a hydrocarbon in a sample, e.g., in marine sediments, muds, sands and the like, or in a solution, e.g., an aqueous solution, such as a production water, fresh water, underground water or seawater. In alternative embodiments, the invention provides compositions, e.g., nucleic acid probes or primers or primer pairs, for use as sensors and/or identifying agents to detect the presence of a hydrocarbon in a sample (e.g., in fresh water, underground water or seawater, or a marine mud, sand or sediment), where the presence of the hydrocarbon indicates e.g., the presence of a subsurface oil, petroleum or gas accumulation or deposit. In alternative embodiments, the invention provides compositions and methods for use as tools for offshore oil exploration activities.
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公开(公告)号：WO0177392B1
公开(公告)日：2003-07-03
申请号：PCT/US0111609
申请日：2001-04-10
Applicant: ASHBY MATTHEW
Inventor： ASHBY MATTHEW
CPC classification number: G06F19/22 , C12Q1/6809 , C12Q1/683 , C12Q1/6869 , C12Q1/6888 , C12Q2600/156 , G06F19/18 , Y10T436/21 , C12Q2525/191 , C12Q2525/151 , C12Q2521/313 , C12Q2525/131
Abstract: The present invention relates to methods for performing surveys of the genetic diversity of a population. The invention also relates to methods for performing genetic analysis of a population. The invention further relates to methods for the creation of databases comprising the survey information and the databases created by these methods. The invention also relates to methods for analyzing the information to correlate the presence of nucleic acid markers with desired parameters in a sample. These methods have application in the fields of geochemical exploration, agriculture, bioremediation, environmental analysis, clinical microbiology, forensic science and medicine.
Abstract translation: 本发明涉及进行群体遗传多样性调查的方法。 本发明还涉及用于进行群体的遗传分析的方法。 本发明还涉及用于创建数据库的方法，该数据库包括调查信息和由这些方法创建的数据库。 本发明还涉及用于分析信息以将核酸标记物的存在与样品中的期望参数相关联的方法。 这些方法适用于地球化学勘探，农业，生物修复，环境分析，临床微生物学，法医学和医学领域。
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5.发明申请COMPOSITIONS AND METHODS FOR IDENTIFYING AND MODIFYING CARBONACEOUS COMPOSITIONS 审中-公开用于鉴定和改性碳组合物的组合物和方法
公开(公告)号：WO2011159924A2
公开(公告)日：2011-12-22
申请号：PCT/US2011040742
申请日：2011-06-16
Applicant: TAXON BIOSCIENCES INC , ASHBY MATTHEW , WOOD LADONNA , LIDSTROEM ULRIKA , CLARKE CHRISTINE , GOULD ALISON , STRAPOC DARIUSZ , LAMBO ADEWALE , HUIZINGA BRADLEY JAMES
Inventor： ASHBY MATTHEW , WOOD LADONNA , LIDSTROEM ULRIKA , CLARKE CHRISTINE , GOULD ALISON , STRAPOC DARIUSZ , LAMBO ADEWALE , HUIZINGA BRADLEY JAMES
CPC classification number: C12P5/023 , C09K8/582 , C12N1/20 , C12Q1/04 , E21B43/16 , E21B43/295 , Y02E50/343 , Y02P20/128
Abstract: This invention generally relates to natural gas and methylotrophic energy generation, bio-generated fuels and microbiology. In alternative embodiments, the invention provides nutrient amendments and microbial compositions, e.g., consortia, that are both specifically optimized to stimulate methanogenesis, or for "methylotrophic" or other conversions. In alternative embodiments, the invention provides methods to develop nutrient amendments and microbial compositions that are both specifically optimized to stimulate methanogenesis in a given reservoir. The invention also provides methods for the evaluation of potentially damaging biomass formation and scale precipitation resulting from the addition of nutrient amendments. In other embodiments, the invention provides methods for simulating biogas in sub-surface conditions using a computational model.
Abstract translation: 本发明一般涉及天然气和甲基营养能量的产生，生物燃料和微生物学。 在替代实施方案中，本发明提供营养物修饰物和微生物组合物，例如联合体，其都被特别优化以刺激产甲烷生成，或用于“甲基营养”或其他转化。 在替代实施方案中，本发明提供开发营养物修饰物和微生物组合物的方法，所述营养物质修饰物和微生物组合物都被特别优化以刺激给定储存器中的产甲烷生成。 本发明还提供了用于评估由添加营养物修饰导致的潜在的破坏性生物质形成和水垢沉淀的方法。 在其他实施方案中，本发明提供了使用计算模型来模拟在亚表面条件下的沼气的方法。
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Patent Agency Ranking
公开(公告)号：WO0177392A2
公开(公告)日：2001-10-18
申请号：PCT/US0111609
申请日：2001-04-10
Applicant: ASHBY MATTHEW
Inventor： ASHBY MATTHEW
CPC classification number: G06F19/22 , C12Q1/6809 , C12Q1/683 , C12Q1/6869 , C12Q1/6888 , C12Q2600/156 , G06F19/18 , Y10T436/21 , C12Q2525/191 , C12Q2525/151 , C12Q2521/313 , C12Q2525/131
Abstract: The present invention relates to methods for performing surveys of the genetic diversity of a population. The invention also relates to methods for performing genetic analysis of a population. The invention further relates to methods for the creation of databases comprising the survey information and the databases created by these methods. The invention also relates to methods for analyzing the information to correlate the presence of nucleic acid markers with desired parameters in a sample. These methods have application in the fields of geochemical exploration, agriculture, bioremediation, environmental analysis, clinical microbiology, forensic science and medicine.
Abstract translation: 本发明涉及进行群体遗传多样性调查的方法。 本发明还涉及用于进行群体的遗传分析的方法。 本发明还涉及用于创建数据库的方法，该数据库包括调查信息和由这些方法创建的数据库。 本发明还涉及用于分析信息以将核酸标记物的存在与样品中的期望参数相关联的方法。 这些方法适用于地球化学勘探，农业，生物修复，环境分析，临床微生物学，法医学和医学领域。
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7.发明申请MICROBIAL BIOINDICATORS OF HYDROCARBONS IN WATER AND IN MARINE SEDIMENTS AND METHODS FOR MAKING AND USING THEM 审中-公开烃类在水体和海洋沉积物中的微生物生物调节剂及其制备和使用方法
公开(公告)号：WO2012016215A2
公开(公告)日：2012-02-02
申请号：PCT/US2011046015
申请日：2011-07-29
Applicant: TAXON BIOSCIENCES INC , ASHBY MATTHEW , DIMSTER-DENK DAGO
Inventor： ASHBY MATTHEW , DIMSTER-DENK DAGO
CPC classification number: C12Q1/6888 , C07H21/04 , C12Q1/689 , C12Q2600/16
Abstract: In alternative embodiments, the invention provides products of manufacture and compositions, e.g., nucleic acid probes, for use as identifying agents or indicators to detect the presence of a hydrocarbon in a sample, e.g., in marine sediments, muds, sands and the like, or in a solution, e.g., an aqueous solution, such as a production water, fresh water, underground water or seawater. In alternative embodiments, the invention provides compositions, e.g., nucleic acid probes or primers or primer pairs, for use as sensors and/or identifying agents to detect the presence of a hydrocarbon in a sample (e.g., in fresh water, underground water or seawater, or a marine mud, sand or sediment), where the presence of the hydrocarbon indicates e.g., the presence of a subsurface oil, petroleum or gas accumulation or deposit. In alternative embodiments, the invention provides compositions and methods for use as tools for offshore oil exploration activities.
Abstract translation: 在可选的实施方案中，本发明提供了制造产品和组合物，例如核酸探针，用作识别试剂或指示剂以检测样品中烃的存在，例如在海洋沉积物，泥土，沙子等中， 或在溶液中，例如水溶液如生产用水，淡水，地下水或海水中。 在可选的实施方案中，本发明提供组合物，例如核酸探针或引物或引物对，用作传感器和/或鉴定试剂以检测样品中烃的存在（例如在淡水，地下水或海水中 ，或海洋泥，沙或沉积物），其中烃的存在表明例如存在地下油，石油或天然气积聚或沉积物。 在替代实施方案中，本发明提供了用作海上石油勘探活动工具的组合物和方法。
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公开(公告)号：WO2009049175A3
公开(公告)日：2009-07-02
申请号：PCT/US2008079537
申请日：2008-10-10
Applicant: NUCOR CORP , LINDSEY STEVE , ASHBY MATTHEW
Inventor： LINDSEY STEVE , ASHBY MATTHEW
CPC classification number: B01D46/442 , B01D46/0095
Abstract: Methods and systems for detecting the presence of a leak in a baghouse bag installed in a baghouse system having at least one compartment. The methods include using a system to acquire electrical signals corresponding to the opacity of gas flow through an outlet of a baghouse system during a start-up of one or more compartments of the baghouse system and comparing the electrical signals corresponding to the opacity of the gas flow with electrical signals characteristic of a leak in at least one of the baghouse bags of the baghouse system.
Abstract translation: 用于检测安装在具有至少一个隔室的袋滤室系统中的袋滤室袋中存在泄漏的方法和系统。 该方法包括使用系统来获取与布袋除尘系统的一个或多个隔室的启动期间通过袋滤室系统的出口的气流的不透明度相对应的电信号，并比较对应于气体的不透明度的电信号 用袋式除尘器系统的至少一个袋式除尘器袋中的泄漏的电信号流动。
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公开(公告)号：WO2009049175A2
公开(公告)日：2009-04-16
申请号：PCT/US2008/079537
申请日：2008-10-10
Applicant: NUCOR CORPORATION , LINDSEY, Steve , ASHBY, Matthew
Inventor： LINDSEY, Steve , ASHBY, Matthew
CPC classification number: B01D46/442 , B01D46/0095
Abstract: Methods and systems for detecting the presence of a leak in a baghouse bag installed in a baghouse system having at least one compartment. The methods include using a system to acquire electrical signals corresponding to the opacity of gas flow through an outlet of a baghouse system during a start-up of one or more compartments of the baghouse system and comparing the electrical signals corresponding to the opacity of the gas flow with electrical signals characteristic of a leak in at least one of the baghouse bags of the baghouse system.
Abstract translation: 用于检测安装在具有至少一个隔间的袋式除尘器系统中的袋装袋中的泄漏的存在的方法和系统。 所述方法包括使用系统来获取对应于袋式系统的一个或多个室的起动期间通过袋式排气系统的出口的气体流动的不透明度的电信号，并且比较与气体的不透明度相对应的电信号 在袋式垃圾箱系统的至少一个袋式垃圾袋中泄漏特征的电信号流动。
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公开(公告)号：WO2001077392A3
公开(公告)日：2001-10-18
申请号：PCT/US2001/011609
申请日：2001-04-10
Applicant: ASHBY, Matthew
Inventor： ASHBY, Matthew
IPC: C12Q1/68
Abstract: The present invention relates to methods for performing surveys of the genetic diversity of a population. The invention also relates to methods for performing genetic analysis of a population. The invention further relates to methods for the creation of databases comprising the survey information and the databases created by these methods. The invention also relates to methods for analyzing the information to correlate the presence of nucleic acid markers with desired parameters in a sample. These methods have application in the fields of geochemical exploration, agriculture, bioremediation, environmental analysis, clinical microbiology, forensic science and medicine.
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