Abstract:
The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 5 have the significance given in claim 1. These compounds can be used for the preparation of medicaments.
Abstract:
The invention relates to compounds of formula (I) wherein A, R 1 to R 8 have the meaning as cited in the description and the claims. Said compounds are useful as Orexin Receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.
Abstract:
The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 5 have the significance given in claim 1. These compounds can be used for the preparation of medicaments.
Abstract:
A chemical compound of formula (I): wherein R1 to R3 are independently selected from hydrogen and alkyl; R5 is selected from alkylthio, arylthio, alkylsulfoxyl, arylsulfoxyl, alkylsulfonyl and arylsulfonyl; R4, R6, and R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, arylsulfoxyl, alkylsulfoxyl, alkylsulfonyl, arylsulfonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino, and pharmaceutically acceptable salts and prodrugs thereof, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus; and sleep apnea, and particularly for the treatment of obesity.
Abstract:
A chemical compound of formula (I) wherein R1 to R3 are independently selected from hydrogen and alkyl; R4 to R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, amino, monoalkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, arylthio, arylsulfoxyl, arylsulfonyl, alkylsulfoxyl, alkylsulfonyl, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino; and R8 is selected from alkyl and alkoxy, and pharmaceutically acceptable salts and prodrugs thereof, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.
Abstract:
The invention relates to compounds of formula (I) wherein A, R1 to R8 have the meaning as cited in the description and the claims. Said compounds are useful as Orexin Receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.
Abstract:
Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder mediated by CB 1 receptors, such as obesity, wherein: R 1 is aryl or heteroaryl; R 2 is alkyl, aryl or heteroaryl; R 3 is alkyl, aryl, heteroaryl, NR 9 R 10 , OR 15, or NR 16 C(O)R 17 ; Y is C=O, C=S, SO 2 , or (CR 7 R 8) p ; m = 1 or 2; n = 1 or 2; and p=1,2,3 or 4, R 7 to R 17 being as defined in the specification; wherein if -Y-R 3 is -C(O)NH(alkyl) then: R 1 and/or R 2 is selected from heteroary1; and/or m and/or n is 2; and/or R 11 and/or R 12 is lower alkyl, or a pharmaceutically acceptable salt or prodrug thereof.
Abstract translation:式(I)化合物及其在治疗中的用途,特别是用于治疗由CB1受体介导的障碍,例如肥胖症,其中:R 1是芳基或杂芳基; R 2是烷基,芳基或杂芳基; R 3是烷基,芳基,杂芳基,NR 9 R 10,OR 15或NR 16 C(O)R 17; Y是C = O,C = S ,SO 2或(CR 7 R 8)> p; m = 1或2; n = 1或2; 和p = 1,2,3或4,R 7至R 17如说明书中所定义; 其中如果-Y-R 3是-C(O)NH(烷基),那么:R 1和/或R 2选自杂芳基; 和/或m和/或n为2; 和/或R 11和/或R 12是低级烷基,或其药学上可接受的盐或前药。
Abstract:
The invention relates to compounds of formula (I) wherein A, R 1 to R 8 have the meaning as cited in the description and the claims. Said compounds are useful as Orexin Receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.