公开(公告)号：WO2023046953A1

公开(公告)日：2023-03-30

申请号：PCT/EP2022/076661

申请日：2022-09-26

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Inventor： HAEMMERLING, Frank ,  BAUMGARTNER, Kai ,  BUSKE, Julia ,  GARIDEL, Patrick ,  MOLNAR, Daniel

IPC: G01N33/58 ,  G01N33/68 ,  G01N33/92

Abstract: The present disclosure is directed to a method (a) for the quantification of polysorbate in aqueous formulations containing polysorbate and one or more (poly)peptides having the following steps: (a.1) providing a sample of the aqueous formulation; (a.2) adding of a solution containing the fluorescent dye N-phenyl-1-naphthylamine to the sample of step (a.1) to obtain a fluorescent dye containing sample to be tested in a fluorescence micelle assay; (a.3) optionally incubating the fluorescent dye containing sample of step (a.2); (a.4) performing a fluorescence micelle assay with the fluorescent dye containing sample obtained in step (a.2) or step (a.3) and (a.5) determining the content of polysorbate present in the sample from the fluorescence micelle assay performed in step (a.4); with the proviso that the method is being performed without the use of a HPLC-system. An additional method (b) of the present invention also allows a high-throughput-screening of a great number of samples. The presence of (poly)peptide(s) does/do not interfere with the fluorescence micelle assay measurement in any way.

公开(公告)号：WO2023042851A1

公开(公告)日：2023-03-23

申请号：PCT/JP2022/034383

申请日：2022-09-14

Applicant: SANTEN PHARMACEUTICAL CO., LTD. ,  BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Inventor： OKI, Kenji ,  NAGANO, Takashi ,  ASANO, Nagayoshi ,  FUJISAWA, Koushi

IPC: A61K31/538 ,  A61P27/02 ,  A61P43/00

Abstract: A compound useful for preventing or treating dry eye and a medicament for preventing and/or treating dry eye comprising the same which does not substantially impact on the intraocular pressure are provided. The present invention relates to a medicament for preventing and/or treating dry eye, comprising olodaterol or a salt thereof as an active ingredient.

公开(公告)号：WO2023031409A1

公开(公告)日：2023-03-09

申请号：PCT/EP2022/074465

申请日：2022-09-02

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Inventor： SMIATEK, Jens ,  BLUHMKI, Erich ,  BURKERT, Oliver ,  KOHLER, Benjamin Joshua ,  LINK, Selina ,  MILLER, Melanie

IPC: G01N21/64 ,  G01N21/78 ,  G01J3/44 ,  G01N21/29 ,  G01N21/77

Abstract: The disclosure relates to determining a color value (12) or corresponding property of a protein-containing solution (2) or of a protein-containing product (3) prepared therefrom, comprising applying exciting fluorescent radiation (5) to the solution (2) or product (3), measuring at least one property, preferably a spectrum (6A) or corresponding feature, of the fluorescent radiation (6), and determining, based on a correlation between the at least one property of the fluorescent radiation (6) and the color value (12) or corresponding property, the present or future color value (12) or corresponding property of the solution (2) or product (3).

公开(公告)号：WO2022106551A1

公开(公告)日：2022-05-27

申请号：PCT/EP2021/082162

申请日：2021-11-18

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Inventor： GAO, Joe, Ju ,  JANKOVSKY, Corinne, B.

IPC: A61P37/00 ,  C07C57/00 ,  C07C63/00 ,  C07D487/04 ,  A61K31/519

Abstract: The present invention relates to co-crystal forms of the following compound (I).

公开(公告)号：WO2022106548A1

公开(公告)日：2022-05-27

申请号：PCT/EP2021/082159

申请日：2021-11-18

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Inventor： GAO, Joe, Ju ,  ZENG, Xingzhong

IPC: A61P37/00 ,  C07D487/04 ,  A61K31/519

Abstract: The present invention relates to alternative forms of the following compound (I)

公开(公告)号：WO2022090101A1

公开(公告)日：2022-05-05

申请号：PCT/EP2021/079442

申请日：2021-10-25

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Inventor： GROLL, Klaus ,  PANGERL, Michael ,  WANG, Yanling ,  XING, Lidong ,  XU, Jianping ,  ZHANG, Pinjie ,  ZHANG, Yongsheng ,  ZHU, Zhibin

IPC: C07D239/42

Abstract: The invention is directed to the commercially synthetic process of 2,4-Dichloro-5-amino- pyrimidine, starting from 5-nitrouracil.

公开(公告)号：WO2022053703A1

公开(公告)日：2022-03-17

申请号：PCT/EP2021/075184

申请日：2021-09-14

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Inventor： WOLLMANN, Guido ,  DAS, Krishna ,  DEROUAZI, Madiha ,  BELNOUE, Elodie ,  ELBERS, Knut

IPC: A61K39/00 ,  A61K39/385 ,  A61P35/00

Abstract: The present invention pertains to the provision of a vaccine comprising a first component (K) and a second component (V), wherein the first component (K) comprises a complex in which a cell penetrating peptide, an antigenic domain and a TLR agonist are functionally linked and the second component (V) comprises an oncolytic recombinant vesicular stomatitis virus expressing an antigenic domain. The invention further pertains to the use of the inventive vaccine in the treatment of cancer. The invention also provides a recombinant vesicular stomatitis virus expressing an antigenic domain and its use in cancer vaccines.

公开(公告)号：WO2022002993A1

公开(公告)日：2022-01-06

申请号：PCT/EP2021/067935

申请日：2021-06-30

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Inventor： HERRMANN, Frank

IPC: A61M15/00 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/0036 ,  A61M15/0066 ,  A61M15/0073 ,  A61M15/0081 ,  A61M15/0088 ,  A61M15/009 ,  A61M2205/02 ,  A61M2205/103 ,  A61M2205/273 ,  A61M2205/8281

Abstract: A nebulizer for nebulizing a fluid is proposed. The nebulizer comprises an indicator device with a rotatable indicator element for counting or indicating a number of actuations performed or still possible with the nebulizer and a rotatable shaft which rotatably drives the indicator element. The indicator device is non-detachably attached to the shaft and/or to an inner part of the nebulizer. The nebulizer may further comprise a positioning device that keeps the shaft in a defined rotational position and/or blocks the shaft from rotating backwards.

公开(公告)号：WO2022002782A1

公开(公告)日：2022-01-06

申请号：PCT/EP2021/067470

申请日：2021-06-25

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Inventor： BINDER, Florian, Paul, Christian ,  FLECK, Martin, Thomas ,  WILLWACHER, Jens

IPC: A61K31/506 ,  A61P11/00 ,  A61P11/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

公开(公告)号：WO2021245111A1

公开(公告)日：2021-12-09

申请号：PCT/EP2021/064728

申请日：2021-06-02

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Inventor： MUELLER, Philipp ,  ERB, Klaus ,  ERLMANN, Patrik ,  WOLLMANN, Guido

IPC: A61K35/766 ,  C07K14/005 ,  C07K14/705 ,  C12N15/86 ,  C12N7/00 ,  A61K45/06 ,  C07K14/70532 ,  C07K2319/02 ,  C07K2319/30 ,  C12N2760/10022 ,  C12N2760/20032 ,  C12N2760/20043 ,  C12N2760/20232 ,  C12N2760/20243 ,  C12N2760/20245

Abstract: The present invention relates to the field of oncolytic viruses and in particular to a recombinant rhabdovirus, such as vesicular stomatitis virus encoding in its genome for a CD80 extracellular domain Fc-fusion protein. The invention is further directed to the use of the recombinant virus in the treatment of cancer, and also to methods for producing such viruses..