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公开(公告)号：WO2011141512A2
公开(公告)日：2011-11-17
申请号：PCT/EP2011057621
申请日：2011-05-11
Applicant: ARTELIS S A , KARERANGABO DIDIER , CARDON JULIEN , CASTILLO GONZALEZ JOSE ANTONIO
Inventor： KARERANGABO DIDIER , CARDON JULIEN , CASTILLO GONZALEZ JOSE ANTONIO
Abstract: A bioreactor (1) for the culture of cells (C) comprising a stack of carriers (7) for cell (C) adherence and liquid medium (M) distribution. The carriers (7) are stacked so as to define levels (6) between adjacent carriers (7) for the flow of the liquid medium (M). Adjacent levels (6) are fluidly interconnected via open spaces (2) so that the liquid medium (M) can flow from one level (6) to an adjacent level (6). The open spaces (2) between a first and an adjacent second level (6') do not overlap with the one or more open spaces (2) between the second level (6') and an adjacent third level (6''). One or more of the carriers may also include an area adapted to prevent cell adhesion or growth, thereby allowing for the viewing of cell growth on adjacent carriers from a vantage point external to the bioreactor. Related methods are also disclosed.
Abstract translation: 用于细胞培养的生物反应器（1）（C）包括用于细胞（C）粘附和液体介质（M）分布的载体（7）的堆叠。 载体（7）被堆叠以便限定用于液体介质（M）的流动的相邻载体（7）之间的水平（6）。 相邻的水平面（6）通过开放空间（2）流体地互连，使得液体介质（M）可以从一个水平面（6）流到相邻的水平面（6）。 第一和第二级（6'）之间的开放空间（2）不与第二级（6'）和相邻的第三级（6“）之间的一个或多个开放空间（2）重叠。 一个或多个载体还可以包括适于防止细胞粘附或生长的区域，从而允许从生物反应器外部的有利位置观察相邻载体上的细胞生长。 还公开了相关方法。
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公开(公告)号：WO2011141512A3
公开(公告)日：2011-11-17
申请号：PCT/EP2011/057621
申请日：2011-05-11
Applicant: ARTELIS S.A. , KARERANGABO, Didier , CARDON, Julien , CASTILLO GONZALEZ, Jose Antonio
Inventor： KARERANGABO, Didier , CARDON, Julien , CASTILLO GONZALEZ, Jose Antonio
Abstract: A bioreactor (1) for the culture of cells (C) comprising a stack of carriers (7) for cell (C) adherence and liquid medium (M) distribution. The carriers (7) are stacked so as to define levels (6) between adjacent carriers (7) for the flow of the liquid medium (M). Adjacent levels (6) are fluidly interconnected via open spaces (2) so that the liquid medium (M) can flow from one level (6) to an adjacent level (6). The open spaces (2) between a first and an adjacent second level (6') do not overlap with the one or more open spaces (2) between the second level (6') and an adjacent third level (6''). One or more of the carriers may also include an area adapted to prevent cell adhesion or growth, thereby allowing for the viewing of cell growth on adjacent carriers from a vantage point external to the bioreactor. Related methods are also disclosed.
