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公开(公告)号：WO2013014208A2
公开(公告)日：2013-01-31
申请号：PCT/EP2012/064632
申请日：2012-07-25
Applicant: GLAXO GROUP LIMITED , ASHMAN, Claire , CATCHPOLE, Ian Richard , HUGHES-THOMAS, Zoe , LEWIS, Alan Peter , STEWARD, Michael
Inventor： ASHMAN, Claire , CATCHPOLE, Ian Richard , HUGHES-THOMAS, Zoe , LEWIS, Alan Peter , STEWARD, Michael
IPC: C07K16/22
CPC classification number: C07K16/22 , A61K2039/505 , A61K2039/54 , A61K2039/70 , C07K16/46 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/60 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs.
Abstract translation: 本发明涉及包含通过抗体的单链Fc区分离的一个或两个表位结合结构域的抗原结合构建体，其中能够结合VEGF的每个表位结合域与包含本发明的两个抗原结合构建体的二聚体， 包含所述二聚体的药物组合物及其用于治疗与VEGF信号传导相关的疾病，例如糖尿病性黄斑水肿（DME），湿性年龄相关性黄斑变性（湿性AMD），糖尿病性视网膜病变，视网膜静脉阻塞（RVO）和角膜 新血管形成和编码所述抗原结合构建体的多核苷酸序列。
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公开(公告)号：WO2009040336A1
公开(公告)日：2009-04-02
申请号：PCT/EP2008/062652
申请日：2008-09-23
Applicant: GLAXO GROUP LIMITED , BURBIDGE, Stephen Anthony , CATCHPOLE, Ian Richard , ELLIS, Jonathan Henry , FORD, Susannah Karen , GERMASCHEWSKI, Volker , KUMAR, Umesh , PHILPOTT, Karen Louise , SODEN, Peter Ernest
Inventor： BURBIDGE, Stephen Anthony , CATCHPOLE, Ian Richard , ELLIS, Jonathan Henry , FORD, Susannah Karen , GERMASCHEWSKI, Volker , KUMAR, Umesh , PHILPOTT, Karen Louise , SODEN, Peter Ernest
IPC: A61P27/12
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/567
Abstract: The present invention relates to methods of treating diseases or disorders affecting the eye or optic nerve characterised by elevated β-amyloid levels or β-amyloid deposits, particularly age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with antigen binding proteins that bind β-amyloid peptide and in particular human β-amyloid peptide.
Abstract translation: 本发明涉及治疗影响眼睛或视神经的疾病或病症的方法，其特征在于β-淀粉样蛋白水平升高或β-淀粉样沉积，特别是年龄相关性黄斑变性和青光眼型疾病和β-淀粉样蛋白依赖性白内障形成，具有抗原结合 结合β-淀粉样肽，特别是人β-淀粉样肽的蛋白质。
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公开(公告)号：WO2006136460A3
公开(公告)日：2007-06-14
申请号：PCT/EP2006006264
申请日：2006-06-20
Applicant: GLAXO GROUP LTD , CATCHPOLE IAN RICHARD , PAPANICOLAOU IRENE
Inventor： CATCHPOLE IAN RICHARD , PAPANICOLAOU IRENE
CPC classification number: A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55577 , C12N2710/10343 , C12N2740/16034
Abstract: The present invention provides a novel adjuvant for polynucleotide vaccines, and in particular the present invention provides immunogenic compositions comprising a polynucleotide encoding an antigen capable of eliciting an immune response and an adjuvant comprising an immunostimulatory quantity of a gemini surfactant, or a derivative thereof. The invention further comprises polynucleotide vaccines that comprise, or are administered in association with, a composition that comprises a gemini surfactant compound. The polynucleotide vaccines of the present invention are vaccines that encode an antigen against which it is desired to generate an immune response, and in particular the polynucleotide vaccine may be a DNA vaccine. Also provided by the present invention is the use of gemini surfactants in the manufacture of a polynucleotide vaccine composition for the purpose of enhancing the immune response against the specific antigen that is encoded by the polynucleotide vaccine. Vaccine compositions, kits comprising separate polynucleotide composition and adjuvant compositions for separate or simultaneous administration, methods of manufacture of the vaccines and kits, and methods of treatment of individuals with the immunogencic compositions and vaccines of the present invention, are provided.
Abstract translation: 本发明提供了用于多核苷酸疫苗的新型佐剂，特别是本发明提供了包含编码能引发免疫应答的抗原的多核苷酸的免疫原性组合物和包含免疫刺激量的双子表面活性剂或其衍生物的佐剂。 本发明还包括包含或与包含双子表面活性剂化合物的组合物结合施用的多核苷酸疫苗。 本发明的多核苷酸疫苗是编码希望产生免疫应答的抗原的疫苗，特别是多核苷酸疫苗可以是DNA疫苗。 本发明还提供了双子座表面活性剂在制造多核苷酸疫苗组合物中的用途，以增强针对由多核苷酸疫苗编码的特异性抗原的免疫应答。 提供疫苗组合物，包含单独的多核苷酸组合物和用于单独或同时施用的佐剂组合物的试剂盒，疫苗和试剂盒的制备方法以及用本发明的免疫原性组合物和疫苗处理个体的方法。
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公开(公告)号：WO2003061636A3
公开(公告)日：2003-07-31
申请号：PCT/GB2003/000282
申请日：2003-01-23
Applicant: GLAXO GROUP LIMITED , CATCHPOLE, Ian, Richard
Inventor： CATCHPOLE, Ian, Richard
IPC: A61K9/70
Abstract: The present invention relates to efficient devices for administration of DNA based pharmaceutical agents into mammalian skin. In a particularly preferred aspect of the present invention there is provided devices for administration of DNA vaccines into the skin of the mammal, and preferably into human skin. The present invention provides a microneedle DNA pharmaceutical agent delivery device having at least one skin-piercing element which comprises a support member coated with a solid reservoir medium containing, in solid solution or suspension within it, the DNA pharmaceutical agent, and a stabilising agent that inhibits the degradative effects of free radicals. Preferably the solid pharmaceutical reservoir medium coated onto such devices is a polyol, preferably being a polyol in an amorphous state (such as a glass).
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公开(公告)号：WO2009135853A2
公开(公告)日：2009-11-12
申请号：PCT/EP2009/055436
申请日：2009-05-05
Applicant: GLAXO GROUP LIMITED , CATCHPOLE, Ian Richard , GOUGH, Gerald Wayne , PAPANICOLAOU, Irene
Inventor： CATCHPOLE, Ian Richard , GOUGH, Gerald Wayne , PAPANICOLAOU, Irene
IPC: A61K9/51
CPC classification number: A61K9/5138 , A61K9/0051 , A61K9/1647 , A61K9/5153 , A61K9/5192 , A61K2039/505 , Y02A50/394
Abstract: The present invention provides particulate carriers comprising encapsulated biologically active agents such as proteins for ocular delivery. Also provided are methods of delivery of proteins to the eye in nanoparticles, and uses of compositions comprising such particulate carriers in treatment.
Abstract translation: 本发明提供了包含包封的生物活性剂如用于眼睛递送的蛋白质的颗粒载体。 还提供了在纳米颗粒中将蛋白递送到眼睛的方法，以及在治疗中使用包含这种颗粒载体的组合物。
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公开(公告)号：WO2004052909A2
公开(公告)日：2004-06-24
申请号：PCT/EP2003/013803
申请日：2003-12-04
Applicant: GLAXO GROUP LIMITED , CATCHPOLE, Ian, Richard
Inventor： CATCHPOLE, Ian, Richard
IPC: C07H21/00
CPC classification number: C12N15/117 , A61K2039/55561 , C12N2310/315 , C12N2310/3231 , C12N2310/346
Abstract: The present invention relates to novel compositions comprising DNA attached to an immunostimulatory oligonucleotide (CpG) via a locked nucleic acid oligonucleotide of a defined sequence. In particular the present invention provides compositions comprising a plasmid containing a gene encoding a protein of interest, wherein said plasmid may be introduced to a tissue or cell and the gene expressed, complexed to the LNA -CpG. Also provided is a method of co-synthesis of CpG and LNA to form compositions for use as adjuvants with DNA plasmid vaccines.
Abstract translation: 本发明涉及通过经定义的序列的锁定核酸寡核苷酸连接到免疫刺激性寡核苷酸（CpG）上的DNA的新型组合物。 特别地，本发明提供包含含有编码目的蛋白质的基因的质粒的组合物，其中所述质粒可以被引入到组织或细胞中，并且所述基因与LNA -CpG复合。 还提供了共同合成CpG和LNA以形成用作DNA质粒疫苗佐剂的组合物的方法。
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公开(公告)号：WO03061636A2
公开(公告)日：2003-07-31
申请号：PCT/GB0300282
申请日：2003-01-23
Applicant: GLAXO GROUP LTD , CATCHPOLE IAN RICHARD
Inventor： CATCHPOLE IAN RICHARD
IPC: A61K9/70 , A61K9/14 , A61K9/16 , A61K31/7088 , A61K39/00 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/42 , A61M37/00 , C12N15/89
CPC classification number: A61K9/1676 , A61K9/0014 , A61K9/0021 , A61K9/145 , A61K47/183 , A61K47/26
Abstract: The present invention relates to efficient devices for administration of DNA based pharmaceutical agents into mammalian skin. In a particularly preferred aspect of the present invention there is provided devices for administration of DNA vaccines into the skin of the mammal, and preferably into human skin. The present invention provides a microneedle DNA pharmaceutical agent delivery device having at least one skin-piercing element which comprises a support member coated with a solid reservoir medium containing, in solid solution or suspension within it, the DNA pharmaceutical agent, and a stabilising agent that inhibits the degradative effects of free radicals. Preferably the solid pharmaceutical reservoir medium coated onto such devices is a polyol, preferably being a polyol in an amorphous state such as a glass.
Abstract translation: 本发明涉及用于向哺乳动物皮肤中施用基于DNA的药剂的有效装置。 在本发明的一个特别优选的方面，提供了用于将DNA疫苗施用于哺乳动物皮肤，优选进入人体皮肤的装置。 本发明提供了一种具有至少一个皮肤刺穿元件的微针DNA药剂递送装置，其包括涂覆有固体储存介质的支撑构件，该固体储存介质在其中具有固体溶液或悬浮液中的DNA药剂和稳定剂， 抑制自由基的降解作用。 优选地，涂覆在这种装置上的固体药物储存介质是多元醇，优选是非晶状态的多元醇，例如玻璃。
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公开(公告)号：WO0102594A3
公开(公告)日：2001-11-15
申请号：PCT/GB0002569
申请日：2000-07-05
Applicant: GLAXO GROUP LTD , GREAVES DAVID ROBERT , THOMSEN LINDY , CATCHPOLE IAN RICHARD , FORD MARTIN JAMES
Inventor： GREAVES DAVID ROBERT , THOMSEN LINDY , CATCHPOLE IAN RICHARD , FORD MARTIN JAMES
IPC: C12N15/09 , A61K35/76 , A61K38/00 , A61K39/395 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/85 , C12P21/00 , A61K31/17
CPC classification number: C07K14/4705 , A61K48/00 , A61K2039/51 , C12N15/85 , C12N2830/00 , C12N2830/42 , C12N2830/46 , C12N2830/85
Abstract: The present invention provides novel DNA constructs comprising a transcriptional regulatory sequence comprising a polynucleotide derivable from the eIF4A1 gene promoter. In preferred embodiments, the polynucleotide further comprises a polynucleotide derivable from the eIF4A gene introns, particularly intron 1. Host cells harbouring the constructs are also provided. These novel constructs have applications in gene therapy, DNA vaccines and in the commercial production of proteins.
Abstract translation: 本发明提供了包含转录调节序列的新型DNA构建体，所述转录调节序列包含可得自eIF4A1基因启动子的多核苷酸。 在优选的实施方案中，多核苷酸还包含衍生自eIF4A基因内含子的多核苷酸，特别是内含子1.还提供了携带该构建体的宿主细胞。 这些新型构建体在基因治疗，DNA疫苗和蛋白质的商业化生产中都有应用。
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公开(公告)号：WO2009135853A3
公开(公告)日：2011-05-12
申请号：PCT/EP2009055436
申请日：2009-05-05
Applicant: GLAXO GROUP LTD , CATCHPOLE IAN RICHARD , GOUGH GERALD WAYNE , PAPANICOLAOU IRENE
Inventor： CATCHPOLE IAN RICHARD , GOUGH GERALD WAYNE , PAPANICOLAOU IRENE
IPC: A61K9/51
CPC classification number: A61K9/5138 , A61K9/0051 , A61K9/1647 , A61K9/5153 , A61K9/5192 , A61K2039/505
Abstract: The present invention provides particulate carriers comprising encapsulated biologically active agents such as proteins for ocular delivery. Also provided are methods of delivery of proteins to the eye in nanoparticles, and uses of compositions comprising such particulate carriers in treatment.
Abstract translation: 本发明提供了包含包封的生物活性剂如用于眼睛递送的蛋白质的颗粒载体。 还提供了在纳米颗粒中将蛋白递送到眼睛的方法，以及在治疗中使用包含这种颗粒载体的组合物。
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公开(公告)号：WO2002102825A3
公开(公告)日：2002-12-27
申请号：PCT/GB2002/002728
申请日：2002-06-14
Applicant: GLAXO GROUP LIMITED , CATCHPOLE, Ian, Richard
Inventor： CATCHPOLE, Ian, Richard
IPC: C12N15/87
Abstract: The present invention relates to compositions comprising DNA attached to one or more functional moities via a locked nucleic acid oligonucleotide. In particular the present invention provides compositions comprising a plasmid containing a gene encoding a protein of interest, wherein said plasmid may be introduced to a tissue or cell and the gene expressed, complexed to the LNA-functional moiety.
