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公开(公告)号：WO2018102006A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/051837
申请日：2017-09-15
Applicant: ENSEMBLE THERAPEUTICS CORPORATION
Inventor： BRIGGS, Timothy, F. , CIPRIANI, Tyler, J. , DAVIS, Heather , DUVALL, Jeremy, R. , HALE, Stephen, P. , JIANG, Jun , LEE, Maurice, D. , MUNCIPINTO, Giovanni , OALMANN, Christopher, J. , SNEDEKER, Cheri
IPC: C07D207/04 , A61K31/407 , A61K31/424 , A61P35/00 , C07D207/16 , C07D413/12 , C07D409/12 , C07D403/12 , C07D403/06 , C07D413/14 , C07D401/14
CPC classification number: A61P35/00 , A61K45/06 , C07D205/04 , C07D207/09 , C07D209/08 , C07D233/64 , C07D257/04 , C07D263/32 , C07D263/56 , C07D271/06 , C07D277/28 , C07D295/185 , C07D403/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07K5/06017 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/06078 , C07K5/06191 , C07K5/0808
Abstract: The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of indoleamine-2,3-dioxygenase (IDO) activity, and methods of treating IDO-related disorders.
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公开(公告)号：WO2014074665A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/068856
申请日：2013-11-07
Applicant: BRISTOL-MYERS SQUIBB COMPANY , ENSEMBLE THERAPEUTICS
Inventor： BORZILLERI, Robert M. , ZHANG, Yong , MILLER, Michael M. , FRALEY, Andrew W.
IPC: C07K7/06 , C07D249/04 , C07D487/06 , C07D487/16 , C07D498/06 , C07D498/16 , A61P35/00
Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
Abstract translation: 公开了利用本发明化合物调节凋亡抑制剂（IAP）的活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病和失调性细胞凋亡障碍的疾病的方法。
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公开(公告)号：WO2013116682A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/024386
申请日：2013-02-01
Applicant: ENSEMBLE THERAPEUTICS CORPORATION
Inventor： TAYLOR, Michael , TERRETT, Nicholas, K. , CONNORS, William, H. , SHORTSLEEVES, Kelley, C. , SEIGAL, Benjamin, A. , SNEDEKER, Cheri , HALE, Stephen, P. , BRIGGS, Timothy, F. , FAVALORO, Frank, G. , CIPRIANI, Tyler, J. , YAN, Dingxue , ALEXANDER, Sethu, L. , THORARENSEN, Atli , XING, Li
IPC: C07D255/02 , C07D257/02 , C07D273/00 , A61P29/00 , A61K31/395
CPC classification number: C07D257/10 , A61K31/366 , A61K31/42 , A61K38/00 , C07D255/02 , C07D257/02 , C07D273/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17-associated disorders.
Abstract translation: 本发明一般涉及式I的大环化合物及其治疗用途。 更具体地说，本发明涉及调节IL-17的活性和/或可用于治疗诸如炎性疾病和其它IL-17相关疾病的医学病症的大环化合物。
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4.发明申请MACROCYCLIC COMPOUNDS FOR THE INHIBITION OF INDOLEAMINE-2,3-DIOXYGENASE ACTIVITY AND USE THEREOF 审中-公开抑制吲哚胺-2,3-二氧化酶活性的大环化合物及其用途
公开(公告)号：WO2018053302A1
公开(公告)日：2018-03-22
申请号：PCT/US2017/051833
申请日：2017-09-15
Applicant: ENSEMBLE THERAPEUTICS CORPORATION
Inventor： BRIGGS, Timothy, F. , ALEXANDER, Sethu, L. , CIPRIANI, Tyler, J. , DAVIS, Heather , DUVALL, Jeremy, R. , HALE, Stephen P. , JIANG, Jun , LEE, Maurice, D., IV , MEHOVIC, Revonda, M. , MUNCIPINTO, Giovanni , OALMANN, Christopher, J. , SHORTSLEEVES, Kelley, C. , TERRETT, Nicholas, K.
IPC: C07D498/18 , C07D498/04 , A61K31/407 , A61K31/424 , A61P35/00
CPC classification number: C07D498/04 , A61K31/407 , A61K31/4245 , A61P35/00 , C07D498/18
Abstract: The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of indoleamine-2,3-dioxygenase (IDO) activity, and methods of treating IDO-related disorders.
Abstract translation: 本发明涉及用作吲哚胺-2,3-双加氧酶（IDO）活性拮抗剂的化合物及其药学上可接受的组合物，以及治疗IDO相关病症的方法。
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公开(公告)号：WO2014066726A2
公开(公告)日：2014-05-01
申请号：PCT/US2013066749
申请日：2013-10-25
Applicant: ENSEMBLE THERAPEUTICS CORPORATION
Inventor： ALEXANDER SETHU L , BRIGGS THIMOTY F , FAVALORO FRANK G JR , HALE STEPHEN P , SEIGAL BENJAMIN A , SHORTSLEEVES KELLEY C , SNEDEKER CHERI , TAYLOR MICHAEL , TERRETT NICHOLAS K , YAN DINGXUE , NOWAK PAWEL WOJCIECH , DENNY RAJIAH ALDRIN , CHRUNYK BORIS ANDREW , SAHASRABUDHE PARAG VASANT , WITHKA JANE MARIE
CPC classification number: C07C255/60 , C07C237/22 , C07C239/22 , C07C271/28 , C07C309/15 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D205/04 , C07D205/12 , C07D207/08 , C07D207/14 , C07D207/16 , C07D209/18 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/56 , C07D213/71 , C07D213/75 , C07D213/81 , C07D249/04 , C07D249/18 , C07D263/58 , C07D271/07 , C07D295/185 , C07D309/14 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D417/04 , C07D498/04
Abstract: The invention relates generally to compounds and their therapeutic use. More particularly, the invention relates to compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17 associated disorders.
Abstract translation: 本发明一般涉及化合物及其治疗用途。 更具体地说，本发明涉及调节IL-17的活性和/或可用于治疗诸如炎性疾病和其它IL-17相关疾病的医学病症的化合物。
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公开(公告)号：WO2013071035A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/064342
申请日：2012-11-09
Applicant: ENSEMBLE THERAPEUTICS , BRISTOL-MYERS SQUIBB COMPANY
Inventor： SEIGAL, Benjamin, Adam , TERRETT, Nicholas , CARTER, Percy, H. , BORZILLERI, Robert, M. , ZHANG, Yong , MILLER, Michael, M.
IPC: C07D249/04 , A61P35/00
CPC classification number: C07D498/22 , A61K38/00 , C07D249/04 , C07D498/16 , C07K5/1008 , C07K7/56 , Y02A50/411 , Y02A50/414
Abstract: The invention relates generally to macrocyclic compounds and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of inhibitors of apoptosis (IAPs) and/or are useful in the treatment of medical conditions, such as cancer.
Abstract translation: 本发明一般涉及大环化合物及其治疗用途。 更具体地说，本发明涉及调节细胞凋亡抑制剂（IAP）活性的大环化合物和/或可用于治疗诸如癌症的医学病症。
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7.发明申请METHODS AND COMPOSITIONS FOR NUCLEIC ACID-TEMPLATED SYNTHESIS OF LARGE LIBRARIES OF COMPLEX SMALL MOLECULES 审中-公开用于复合小分子的大型图谱的核酸酸化合成的方法和组合物
公开(公告)号：WO2016109808A1
公开(公告)日：2016-07-07
申请号：PCT/US2015/068308
申请日：2015-12-31
Applicant: ENSEMBLE THERAPEUTICS CORPORATION
Inventor： TERRETT, Nicholas, K. , CONNORS, William, H.
IPC: C40B50/00
CPC classification number: C40B50/00 , C12N15/1031
Abstract: The present invention provides methods and compositions for expanding the scope of chemical reactions that can be performed during nucleic acid-templated organic syntheses, and for producing small molecule libraries of greater size, scope and complexity than previously possible.
Abstract translation: 本发明提供了用于扩展可在核酸模板化有机合成过程中进行的化学反应范围以及用于产生比以前可能的更大尺寸，范围和复杂性的小分子文库的方法和组合物。
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公开(公告)号：WO2014074658A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/068834
申请日：2013-11-07
Inventor： BORZILLERI, Robert M. , ZHANG, Yong , MILLER, Michael M. , SEIGAL, Benjamin A.
IPC: C07D471/08 , C07D471/18 , C07D498/08 , C07D498/18 , C07D498/22 , A61K31/395 , C07K5/00 , A61P35/00
CPC classification number: C07K7/06 , C07D471/08 , C07D471/18 , C07D498/08 , C07D498/18 , C07D498/22 , C07K7/56
Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
Abstract translation: 公开了调节细胞凋亡抑制剂（IAP）的活性的化合物，含有所述化合物的药物组合物以及治疗增殖性疾病和失调性细胞凋亡疾病如癌症的方法，所述化合物利用 发明。
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公开(公告)号：WO2013071039A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/064349
申请日：2012-11-09
Applicant: ENSEMBLE THERAPEUTICS , BRISTOL-MYERS SQUIBB COMPANY
Inventor： SEIGAL, Benjamin Adam , TERRETT, Nicholas , FRALEY, Andrew , CONNORS, William , BRIGGS, Timothy , BORZILLERI, Robert M. , ZHANG, Yong , MATHIEU, Steven , CARTER, Percy H.
Abstract: The invention relates generally to macrocyclic compounds and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of inhibitors of apoptosis (IAPs) and/or are useful in the treatment of medical conditions, such as cancer.
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公开(公告)号：WO2013071027A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/064332
申请日：2012-11-09
Applicant: ENSEMBLE THERAPEUTICS , BRISTOL- MYERS SQUIBB COMPANY
Inventor： SEIGAL, Benjamin, Adam , TERRETT, Nicholas , FRALEY, Andrew , MATHIEU, Steven , CONNORS, William , BRIGGS, Timothy , CARTER, Percy, H. , BORZILLERI, Robert, M. , ZHANG, Yong
IPC: C07D487/06 , C07D487/16 , C07D498/06 , C07D498/16 , A61K31/559 , A61P35/00
CPC classification number: C07D498/16 , C07D487/06 , C07D487/16 , C07D498/06
Abstract: The invention relates generally to macrocyclic compounds and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of inhibitors of apoptosis (IAPs) and/or are useful in the treatment of medical conditions, such as cancer.
Abstract translation: 本发明一般涉及大环化合物及其治疗用途。 更具体地，本发明涉及调节凋亡抑制剂（IAP）的活性的大环化合物和/或可用于治疗诸如癌症的医学病症。
