公开(公告)号：WO2009108690A1

公开(公告)日：2009-09-03

申请号：PCT/US2009/035125

申请日：2009-02-25

申请人： TTI ELLEBEAU, INC. ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY ,  DHARMA THERAPEUTICS ,  KAJIMOTO, Kazuaki ,  YAMAMOTO, Masahiko ,  KIGASAWA, Kaoru ,  KOGURE, Kentaro

发明人： KAJIMOTO, Kazuaki ,  YAMAMOTO, Masahiko ,  KIGASAWA, Kaoru ,  KOGURE, Kentaro

IPC分类号： A61K9/00 ,  A61K48/00 ,  A61K9/127

CPC分类号： A61K9/127 ,  A61K9/0009 ,  A61K48/00

摘要： To provide a composition which is capable of efficiently delivering an siRNA intradermally and of effectively suppressing the expression of a target gene by an RNAi. Provided is a composition for iontophoresis including an siRNA-polycation complex which is charged negatively.

摘要翻译： 提供能够有效地递送siRNA并且通过RNAi有效抑制靶基因表达的组合物。 提供一种用于离子电渗疗法的组合物，其包含负电荷的siRNA-聚阳离子络合物。

公开(公告)号：WO2014168262A1

公开(公告)日：2014-10-16

申请号：PCT/JP2014/060992

申请日：2014-04-11

申请人： D.D.P. CORPORATION ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

发明人： KOGAMI, Yuji ,  SHUTO, Satoshi ,  ARISAWA, Mitsuhiro

IPC分类号： C07D215/14 ,  A61K31/405 ,  A61K31/416 ,  A61K31/47 ,  A61K35/00 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/14 ,  A61P25/28 ,  A61P43/00 ,  C07D209/08 ,  C07D231/56

CPC分类号： C07D209/08 ,  C07D215/14 ,  C07D231/56 ,  C07D401/12

摘要： The invention provides compound (I): wherein each symbol is as defined in the specification, having a tyrosine kinase inhibitory action on Trk receptors such as TrkA, TrkB, TrkC or other tyrosine kinase receptors such as Flt-3, which is useful for the prophylaxis or treatment of proliferative diseases associated with kinase signaling pathway such as tumor or cancer, fibrotic diseases, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, tuberous sclerosis complex, hair loss, and Alzheimer's disease.

摘要翻译： 本发明提供化合物（I）：其中每个符号如说明书中所定义，对Trk受体如TrkA，TrkB，TrkC或其它酪氨酸激酶受体如Flt-3具有酪氨酸激酶抑制作用，其可用于 与肿瘤或癌症等激酶信号通路相关的增殖性疾病的预防或治疗，纤维化疾病，与血管成形术相关的再狭窄，多囊肾病，异常血管生成疾病，结节性硬化综合征，脱发和阿尔茨海默氏病。

公开(公告)号：WO2005093055A1

公开(公告)日：2005-10-06

申请号：PCT/JP2004/004344

申请日：2004-03-26

申请人： FRONTIER SCIENCE CO. LTD. ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY ,  SUGAWARA, Teruo ,  ITO, Keizo

发明人： SUGAWARA, Teruo ,  ITO, Keizo

IPC分类号： C12N15/09

CPC分类号： C12Q1/02

摘要： The invention is a transformed yeast for detecting and measuring a dioxin comprising a dioxin receptor gene, a dioxin receptor nuclear translocator gene, a transcription activation domain gene, a dioxin receptor-binding DNA cis element and a reporter gene and capable of expressing the reporter gene in the presence of the dioxin. The invention is also a reagent for detecting and measuring a dioxin comprising this transformed yeast. The invention is also a kit for detecting and measuring a dioxin comprising this reagent and a proliferation medium.

摘要翻译： 本发明是一种用于检测和测量二恶英的转化酵母，其包含二恶英受体基因，二恶英受体核转运基因，转录活化域基因，二恶英受体结合DNA顺式元件和报告基因，并能够表达报告基因 在二恶英的存在下。 本发明也是用于检测和测量包含该转化酵母的二恶英的试剂。 本发明还是一种用于检测和测量包含该试剂和增殖介质的二恶英的试剂盒。

公开(公告)号：WO2016203283A1

公开(公告)日：2016-12-22

申请号：PCT/IB2015/001177

申请日：2015-06-18

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE - LILLE 1 ,  ECOLE CENTRALE DE LILLE ,  HOKKAIDO UNIVERSITY

发明人： PAUL, Sébastien ,  DUMEIGNIL, Franck ,  KATRYNIOK, Benjamin ,  ARAQUE MARIN, Marcia ,  MURAYAMA, Toru ,  UEDA, Wataru

IPC分类号： C07C51/25 ,  C07C57/04

CPC分类号： C07C51/235 ,  C07C57/04

摘要： The present invention relates to the use of molybdenum and vanadium mixed oxides, optionally iron doped, as catalysts for the oxidation of unsaturated alcohols, in particular allyl alcohol, and also to a process for the production of unsaturated carboxylic acids, in particular acrylic acid, in the gas phase, in the presence of such a catalyst.

摘要翻译： 本发明涉及钼和钒混合氧化物（任选掺杂铁）作为用于不饱和醇，特别是烯丙醇氧化的催化剂的用途，以及用于生产不饱和羧酸，特别是丙烯酸的方法， 在气相中，在这种催化剂的存在下。

公开(公告)号：WO2012039137A3

公开(公告)日：2012-03-29

申请号：PCT/JP2011/005325

申请日：2011-09-21

申请人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY ,  Shionogi & Co., Ltd. ,  MITSUTAKE, Susumu ,  ZAMA, Kota ,  IGARASHI, Yasuyuki ,  YOSHIDA, Tetsuya ,  TANAKA, Yoshikazu ,  TAKEMOTO, Hiroshi

发明人： MITSUTAKE, Susumu ,  ZAMA, Kota ,  IGARASHI, Yasuyuki ,  YOSHIDA, Tetsuya ,  TANAKA, Yoshikazu ,  TAKEMOTO, Hiroshi

IPC分类号： C12N15/113 ,  A61K31/712 ,  A61K31/713

摘要： The problem of the present invention is to prove a medicament for decreasing body weight, a medicament for decreasing visceral fat, a medicament for decreasing triglyceride in the liver, and a method for screening a medicament for ameliorating obesity and fatty liver. The problem is solved by a method comprising measuring an activity of a candidate material for inhibiting a sphingomyelin synthetase wherein if the candidate material has an activity for inhibiting a sphingomyelin synthetase, the candidate material is judged to have at least one function selected from the consisting of an anti-obesity drug, a drug for decreasing visceral fat, a drug for treating fatty liver and an agent for increasing adiponectin expression.

公开(公告)号：WO2009108686A1

公开(公告)日：2009-09-03

申请号：PCT/US2009/035116

申请日：2009-02-25

申请人： TTI ELLEBEAU, INC. ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY ,  DHARMA THERAPEUTICS ,  KAJIMOTO, Kazuaki ,  YAMAMOTO, Masahiko ,  KOGURE, Kentaro ,  HARASHIMA, Hideyoshi

发明人： KAJIMOTO, Kazuaki ,  YAMAMOTO, Masahiko ,  KOGURE, Kentaro ,  HARASHIMA, Hideyoshi

IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K38/00 ,  A61K39/00

CPC分类号： A61K9/0009 ,  A61K9/127 ,  A61K39/39 ,  A61K2039/55555

摘要： Provided is a composition for iontophoresis comprising a negatively-charged protein-liposome complex, in which the protein-liposome complex is formed of a negatively-charged protein and a cationic liposome. Such may provide a composition capable of efficiently delivering a protein having a large molecular weight intradermally and inducing an immune response effectively by iontophoresis.

摘要翻译： 提供了一种用于离子电渗的组合物，其包含带负电荷的蛋白质 - 脂质体复合物，其中蛋白质 - 脂质体复合物由带负电荷的蛋白质和阳离子脂质体形成。 这样可提供能够有效地输送皮内具有大分子量的蛋白质并通过离子电渗法有效地诱导免疫应答的组合物。

公开(公告)号：WO2006049229A1

公开(公告)日：2006-05-11

申请号：PCT/JP2005/020255

申请日：2005-10-28

申请人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY ,  NIPPON SHOKUBAI CO., LTD. ,  MIYAURA, Norio ,  YAMAMOTO, Yasunori ,  NAKATANI, Yasutaka ,  YAMAMOTO, Tetsuya

发明人： MIYAURA, Norio ,  YAMAMOTO, Yasunori ,  NAKATANI, Yasutaka ,  YAMAMOTO, Tetsuya

IPC分类号： C07F5/05

CPC分类号： C07F5/02

摘要： The invention relates to a method for producing hexaalkylborazine represented by formula 2 from a borazine represented by the formula 1, an alkene and a ligand transition-metal complex catalyst. For both formulas 1 and 2, R 1 represents an alkyl group and may be the same or different. R 2 represents a hydrogen atom or an alkyl group, and may be the same or different, and at least one of the R2 is a hydrogen atom, and R 3 represents a an alkyl group, and may be the same or different.

摘要翻译： 本发明涉及由式1表示的环硼烷，烯烃和配位体过渡金属络合物催化剂制备由式2表示的六烷基氮杂硼烷的方法。 对于式1和式2，R 1表示烷基，可以相同或不同。 R 2表示氢原子或烷基，可以相同或不同，R2中的至少一个为氢原子，R 3为 烷基，可以相同或不同。

公开(公告)号：WO2016027383A1

公开(公告)日：2016-02-25

申请号：PCT/JP2014/072080

申请日：2014-08-19

申请人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY ,  UNIVERSITY OF MASSACHUSETTS

发明人： GONG, Jian Ping ,  KUROKAWA, Takayuki ,  SUN, Tao Lin ,  KING, Daniel ,  CROSBY, Alfred

IPC分类号： D06M14/18 ,  A61F2/08 ,  A61F2/10 ,  A61L27/00

CPC分类号： A61F2/08 ,  A61L15/60 ,  A61L27/10 ,  A61L27/16 ,  A61L27/446 ,  A61L27/48 ,  A61L27/52 ,  A61L27/60 ,  A61L2430/10 ,  C08J5/2231 ,  C08J2325/18 ,  C08J2339/08 ,  D06M15/233 ,  D06M15/267 ,  D06M15/285 ,  D06M15/3562 ,  D06M15/3566

摘要： A composite comprising a fabric and a polyampholyte hydrogel is provided. In the composite, the polyampholyte hydrogel is a hydrogel of a polymer bearing randomly dispersed cationic and anionic repeat groups and at least a part of the fabric is coated with the polyampholyte hydrogel. A method of preparation of the composite comprises steps (a) to (c): (a) providing a monomer mixture for preparation of a polyampholyte hydrogel; (b) immersing a fabric in the monomer mixture solution; and (c) polymerizing monomers in the monomer mixture solution to obtain a precursor of the composite.

摘要翻译： 提供了包含织物和聚阴离子水凝胶的复合材料。 在复合材料中，聚阴离子水凝胶是具有随机分散的阳离子和阴离子重复基团的聚合物的水凝胶，并且织物的至少一部分涂覆有聚阴离子水凝胶。 制备复合材料的方法包括步骤（a）至（c）：（a）提供用于制备聚阴离子水凝胶的单体混合物; （b）将织物浸入单体混合溶液中; 和（c）在单体混合物溶液中聚合单体以获得复合材料的前体。

公开(公告)号：WO2014024782A3

公开(公告)日：2014-11-27

申请号：PCT/JP2013070946

申请日：2013-08-01

申请人： NIPPON KAYAKU KK ,  NAT UNIVERESITY CORP HOKKAIDO UNIVERSITY

发明人： UEDA WATARU ,  OMATA KAORI ,  KOBAYASHI YASUSHI ,  HIRAOKA RYOTA ,  OKUMURA KIMITO

IPC分类号： B01J23/30 ,  B01J37/04 ,  B01J37/08 ,  B01J37/10 ,  C07B61/00 ,  C07C51/235 ,  C07C57/05

CPC分类号： B01J23/30 ,  B01J23/002 ,  B01J37/10 ,  B01J2523/00 ,  C07C51/235 ,  C07C57/04 ,  B01J2523/55 ,  B01J2523/56 ,  B01J2523/69

摘要： [Problem] To provide a composite metal oxide catalyst which can produce high yields of acrylic acid from glycerin in a one-step reaction, the catalyst comprising at least tungsten, vanadium, niobium and oxygen, and a method for producing same. Also to provide a method for producing acrylic acid from glycerin using the catalyst. [Solution] A composite metal oxide catalyst which is used to produce acrylic acid from glycerin, and which comprises at least tungsten, vanadium, niobium and oxygen. Also provided are: a method for producing the composite metal oxide catalyst, wherein a mixed liquid obtained by mixing a compound comprising at least tungsten, niobium and vanadium with water is subjected to hydrothermal synthesis, thus forming a solid, and the solid is then fired; and a method for producing acrylic acid from glycerin using the catalyst.

摘要翻译： 为了提供在一步反应中可以从甘油产生高产率丙烯酸的复合金属氧化物催化剂，至少包含钨，钒，铌和氧的催化剂及其制备方法。 还提供使用该催化剂从甘油制备丙烯酸的方法。 [溶液]一种复合金属氧化物催化剂，其用于从甘油生产丙烯酸，并且至少包含钨，钒，铌和氧。 还提供了一种制备复合金属氧化物催化剂的方法，其中通过将至少含有钨，铌和钒的化合物与水混合而获得的混合液体进行水热合成，从而形成固体，然后将固体烧制 ; 以及使用该催化剂从甘油制造丙烯酸的方法。

公开(公告)号：WO2007021022A1

公开(公告)日：2007-02-22

申请号：PCT/JP2006/316286

申请日：2006-08-15

申请人： OHARA INC. ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY ,  HASHIMOTO, Tomohiro ,  MISAWA, Hiroaki

发明人： HASHIMOTO, Tomohiro ,  MISAWA, Hiroaki

IPC分类号： C03C23/00 ,  G02B1/00

CPC分类号： G02B1/12 ,  B82Y20/00 ,  C03C23/0025 ,  G02B1/005 ,  G02B5/1857 ,  G02B2207/101 ,  Y10T428/13 ,  Y10T428/131 ,  Y10T428/249953 ,  Y10T428/249967 ,  Y10T428/249969

摘要： An objective of the present invention is to provide a structure capable of obtaining a higher difference in refractive indices between that of a transparent material and that of a cavity, than in the past, and a manufacturing method thereof, and the present invention provides a structure having a transparent material and an internal cavity which is formed by irradiating said transparent material with a pulse laser beam having a pulse width of 10 x 10 -12 seconds or less, and wherein refractive index of said transparent material at d line is n d → 1.3.

摘要翻译： 本发明的目的是提供一种能够获得与过去相比透明材料和空腔的折射率之间的折射率差较大的结构及其制造方法，本发明提供一种结构 具有通过用脉冲宽度为10×10 -6秒以下的脉冲激光束照射所述透明材料形成的透明材料和内部空腔，并且其中所述透明材料的折射率 在d行是n ？ 1.3。