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    ULTRASOUND SCANNING
    3.
    发明申请
    ULTRASOUND SCANNING 审中-公开
    超声波扫描

    公开(公告)号：WO1998023210A1

    公开(公告)日：1998-06-04

    申请号：PCT/GB1997003259

    申请日：1997-11-27

    Applicant: IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE ,  HEART, Gill ,  KITNEY, Richard, Ian Imperial College of Science Technology and Medicine

    Inventor： IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

    IPC: A61B08/06

    CPC classification number: A61B8/08 ,  G01S7/52026 ,  G01S7/52036 ,  G01S7/52071 ,  G01S15/8979

    Abstract: An ultrasound scanning technique for biological tissue examines the radio frequency signals derived from reflected ultrasonic energy to identify signal parameters indicative of particular tissue histology. Such identification is then used to produce a histological image of the biological tissue. The technique is particularly useful in the examination of blood vessels to identify different types of plaque within the vessel wall. Lipid plaques produce relatively low levels of reflection. Calcified plaques produce high levels of regular reflection. Fibrous plaques may be identified as a highly homogeneous thickened wall area that does not show the characteristics of a lipid plaque. A homogeneity value for the radio frequency signal is calculated for all areas not identified as lipid plaques or calcified plaques and then this homogeneity value is mapped to a colour that is displayed within the histological image.

    Abstract translation: 用于生物组织的超声扫描技术检查从反射的超声波能量得到的射频信号，以识别指示特定组织组织学的信号参数。 然后使用这种鉴定来产生生物组织的组织学图像。 该技术在血管检查中特别有用，以鉴别血管壁内不同类型的斑块。 脂质斑块产生相对较低的反射水平。 钙化斑块产生高水平的定期反射。 纤维斑可以被鉴定为不显示脂质斑块特征的高度均匀的增稠壁面积。 对于未识别为脂质斑块或钙化斑块的所有区域计算射频信号的均匀性值，然后将该均匀性值映射到在组织学图像内显示的颜色。

    VALVE
    5.
    发明申请
    VALVE 审中-公开

    公开(公告)号：WO2023017256A1

    公开(公告)日：2023-02-16

    申请号：PCT/GB2022/052074

    申请日：2022-08-09

    Applicant: IMPERIAL COLLEGE INNOVATIONS LTD

    Inventor： DHARMADASA, Asela Bandara ,  GÓMEZ, Carlos MH ,  PATEL, Manish Kumar ,  BISHOP, Oliver ,  SMART, Nicholas

    IPC: F16K11/083 ,  F16K31/56 ,  F16K31/524 ,  F16K31/60 ,  F16K35/04 ,  A61M16/20

    Abstract: The disclosure relates to a valve (20) for use with breathing assistance apparatus. The valve comprises: a valve body (25) defining first, second and third ports (21, 22, 23); a valve core (27) defining a ported chamber (40) rotatable about a valve axis (28) between: a first stable configuration in which the ported chamber provides fluid communication between the first port and the second port and isolates the third port from the first and second ports; and a second stable configuration in which the ported chamber provides fluid communication between the first port and the third port and isolates the second port from the first and third ports, wherein an outer surface (34) of the valve core is configured to engage with an inner surface (32) of the valve body to define a detent for resisting rotation of the valve core between the first stable configuration and the second stable configuration; and an actuator (30) configured to overcome the detent to rotate the valve core between the first and second stable configurations.

    VERIFYING NEURAL NETWORKS
    7.
    发明申请
    VERIFYING NEURAL NETWORKS 审中-公开

    公开(公告)号：WO2022243570A1

    公开(公告)日：2022-11-24

    申请号：PCT/EP2022/063919

    申请日：2022-05-23

    Applicant: IMPERIAL COLLEGE INNOVATIONS LIMITED

    Inventor： BATTEN, Ben ,  KOUVAROS, Panagiotis ,  LAN, Jianglin ,  LOMUSCIO, Alessio ,  ZHANG, Yang

    IPC: G06N3/04 ,  G06N3/08

    Abstract: There are provided processes for verifying the performance of neural networks across a range of inputs. The neural network comprises nodes arranged in a plurality of layers, and a disclosed process comprises the steps of: obtaining data representing a trained neural network, a set of algebraic constraints on the output of each layer the network, and a range of inputs to the neural network over which the algebraic constraints are to be verified, such that the data defines a verification problem; determining, for each layer of the network, a semidefinite constraint from the algebraic constraints for that layer; determining a set of interlayer constraints which constrain outputs of one or more of the layers to corresponding inputs of one or more adjacent layers; applying a semidefinite programming relaxation subject to the semidefinite constraints and the interlayer constraints across the range of inputs; and based on the outcome of the semidefinite programming relaxation, determining whether the neural network is robust across the range of inputs.

    RNA CONSTRUCT
    9.
    发明申请
    RNA CONSTRUCT 审中-公开

    公开(公告)号：WO2022129945A1

    公开(公告)日：2022-06-23

    申请号：PCT/GB2021/053362

    申请日：2021-12-17

    Applicant: IMPERIAL COLLEGE INNOVATIONS LIMITED ,  VAXEQUITY LTD

    Inventor： SHATTOCK, Robin ,  MCKAY, Paul ,  WATSON, Michael ,  HARPER, Elaine

    IPC: A61K39/00

    Abstract: The invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

    RNA VACCINE
    10.
    发明申请
    RNA VACCINE 审中-公开

    公开(公告)号：WO2022129918A1

    公开(公告)日：2022-06-23

    申请号：PCT/GB2021/053325

    申请日：2021-12-16

    Applicant: IMPERIAL COLLEGE INNOVATIONS LIMITED

    Inventor： SHATTOCK, Robin

    IPC: A61K39/12 ,  A61P31/14 ,  A61K39/00

    Abstract: The invention relates to RNA vaccines, and particularly, although not exclusively, to novel uses and methods for thermally stabilising RNA vaccine formulations, and especially the thermal stabilisation of self-amplifying RNA vaccine formulations. The invention extends to novel vaccine compositions and formulations of temperature stabilised RNA vaccines, and their use in therapy, for example in treating and preventing disease, such as a bacterial or viral infection, and/or in vaccine delivery. The invention also extends to vaccine vials and pre-loaded syringes comprising the novel, thermally stabilised RNA vaccine formulations.

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