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    CANDIDA AURIS DISINFECTANT
    1.
    发明申请
    CANDIDA AURIS DISINFECTANT 审中-公开

    公开(公告)号：WO2023278316A1

    公开(公告)日：2023-01-05

    申请号：PCT/US2022/035107

    申请日：2022-06-27

    申请人： JOHNSON, Lanny, Leo

    发明人： JOHNSON, Lanny, Leo

    IPC分类号： A01N37/10 ,  A61K31/235 ,  A61K31/10 ,  A01P1/00 ,  A01N31/02 ,  A01N37/40 ,  A01P3/00 ,  A61K31/045 ,  A61K31/192 ,  A61P31/10

    摘要： A method of disinfecting Candida auris is disclosed including treating a surface with a solution comprising 3,4-Dihydroxybenzoic acid ethyl ester. The solution may further include protocatechuic acid. The solution may include an alcohol. The alcohol may include methanol, ethanol, or isopropyl alcohol. The surface may include a solid surface, a porous or semi-porous surface, or a cloth-like surface. The surface may include a surface on skin, clothes, masks, a medical device, food processing equipment, hearing aid or a surgical implant. The surface may include a surface in a healthcare facility.

    COMPOSITIONS COMPRISING PROTOCATECHUIC ACID AND METHODS OF USE
    2.
    发明申请
    COMPOSITIONS COMPRISING PROTOCATECHUIC ACID AND METHODS OF USE 审中-公开

    公开(公告)号：WO2022019996A1

    公开(公告)日：2022-01-27

    申请号：PCT/US2021/033345

    申请日：2021-05-20

    申请人： JOHNSON, Lanny Leo

    发明人： JOHNSON, Lanny Leo

    IPC分类号： A01N25/02 ,  A01N37/40 ,  A61K9/00 ,  A61K31/192

    摘要： This disclosure is directed to methods of using compositions comprising protocatechu ic acid (RCA) to kill virus including a Covid-19 virus. The compositions generally comprise protocatechuic acid, a liquid vehicle, and a stabilizer. In embodiments, the liquid vehicle comprises an alcohol and/or water. In preferred embodiments, the oil is an essential oil. In embodiments, the compositions may comprise principally protocatechuic acid, liquid vehicle, and stabilizer as the main ingredients. The compositions may be sprayed onto various products and articles of manufacture, and mammalian and human skin, to kill virus including a Covid-19 virus and to further protect the product or human skin for a period of time up to 24 hours or more. In preferred embodiments, an alcohol component kills virus on contact, and after drying, the residual surface RCA coating provides a continuing anti-viral function.

    METHODS OF DIAGNOSING AND TREATING INFECTED IMPLANTS
    4.
    发明申请
    METHODS OF DIAGNOSING AND TREATING INFECTED IMPLANTS 审中-公开

    公开(公告)号：WO2020033677A1

    公开(公告)日：2020-02-13

    申请号：PCT/US2019/045693

    申请日：2019-08-08

    申请人： JOHNSON, Lanny, Leo

    发明人： JOHNSON, Lanny, Leo

    IPC分类号： A61K31/192 ,  A61K31/11 ,  A61P31/04 ,  A61B8/12

    摘要： The present invention relates to protocatechuic acid, 2,4,6- trihydroxybenzaldehyde, or a mixture or combination thereof, for use in a method of treating microbial infections on the surfaces of an implant or other surfaces near an implant in a patient. In particular, the methods are useful for treating biofilm infections. The methods include the use of minimally invasive techniques, including the use of ultrasound for facilitating the detection of biofilm infections on the implant or other surface of a patient and destroying the infection by administering an anthocyanin or an anthocyanidin or metabolite thereof. In particular, protocatechuic acid (RCA) or 2,4,6 trihydroxybenzaldehyde (2,4,6 THBA) for use in the treatment of an infected implant or other surface of a patient is described herein.

    COMPOSITIONS AND TREATMENTS FOR MICROBIAL PERSISTER CELLS
    5.
    发明申请
    COMPOSITIONS AND TREATMENTS FOR MICROBIAL PERSISTER CELLS 审中-公开

    公开(公告)号：WO2023038776A1

    公开(公告)日：2023-03-16

    申请号：PCT/US2022/040842

    申请日：2022-08-19

    申请人： JOHNSON, Lanny Leo

    发明人： JOHNSON, Lanny Leo

    IPC分类号： A61K31/192 ,  A61K9/00

    摘要： This disclosure is directed to methods and compositions including protocatechuic acid for destroying, inactivating, and/or inhibiting a persister cell including contacting a persister cell with a composition comprising protocatechuic acid crystals. The composition may include a liquid vehicle, and a stabilizer. The stabilizer may be an oil including an essential oil. The liquid vehicle may include an alcohol including isopropyl alcohol and/or ethanol.

    COMPOSITIONS INCLUDING A CANNABINOID AND PROTOCATECHUIC ACID
    6.
    发明申请
    COMPOSITIONS INCLUDING A CANNABINOID AND PROTOCATECHUIC ACID 审中-公开

    公开(公告)号：WO2022216687A1

    公开(公告)日：2022-10-13

    申请号：PCT/US2022/023451

    申请日：2022-04-05

    申请人： JOHNSON, Lanny Leo

    发明人： JOHNSON, Lanny Leo

    IPC分类号： A61K31/05 ,  A61K31/352 ,  A61K31/192

    摘要： A composition comprising a therapeutically effective amount of a cannabinoid and protocatechuic acid is provided. The disclosure further provides a method of treating inflammation comprising administering a composition comprising a therapeutically effective amount of a cannabinoid and protocatechuic acid to a patient in need thereof. The disclosure further provides a method of treating inflammation including administering a composition including protocatechuic acid and a composition including a cannabinoid to a patient in need thereof. In embodiments, the composition including protocatechuic acid and the composition including a cannabinoid may be administered simultaneously within about 60 minutes of each other. In embodiments, the cannabinoid includes Cannabidiol (CBD).

    WOUND CLOSURE DEVICES COMPRISING PROTOCATECHUIC ACID
    8.
    发明申请
    WOUND CLOSURE DEVICES COMPRISING PROTOCATECHUIC ACID 审中-公开

    公开(公告)号：WO2022087425A1

    公开(公告)日：2022-04-28

    申请号：PCT/US2021/056270

    申请日：2021-10-22

    申请人： JOHNSON, Lanny Leo

    发明人： JOHNSON, Lanny Leo

    IPC分类号： A01N37/40 ,  A01N31/02 ,  A01N35/04 ,  A01N43/16 ,  A23B7/154 ,  A23L3/3508 ,  A61K8/14 ,  A61K9/08 ,  A61K9/127

    摘要： A suture or a surgical or wound closure staple is disclosed that includes protocatechuic acid. The protocatechuic acid may be coated on, or impregnated in, the suture or wound closure staple. The suture or wound closure staple may include polypropylene, nylon, polyester, and/or braided polyester, catgut, 85/15 D,L lactide/glycolide, and/or 910 Vicryl. The protocatechuic acid may coat 25% or more of the surface of the suture or surgical staple. In embodiments, the protocatechuic acid may have a purity of 95% or greater. The protocatechuic acid may include crystalline protocatechuic acid.

    METHODS OF TREATING SARS COV-2 VIRUS WITH PROTOCATECHUIC ACID
    9.
    发明申请
    METHODS OF TREATING SARS COV-2 VIRUS WITH PROTOCATECHUIC ACID 审中-公开

    公开(公告)号：WO2022019997A1

    公开(公告)日：2022-01-27

    申请号：PCT/US2021/033357

    申请日：2021-05-20

    申请人： JOHNSON, Lanny Leo

    发明人： JOHNSON, Lanny Leo

    IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K31/192

    摘要： The present disclosure provides methods for killing the SARS CoV-2 virus in mammals and treating the Coronavirus Disease-19 (Covid-19) in mammals including humans using compositions including protocatechuic acid. The present disclosure provides methods and pharmaceutical and nutraceutical compositions that reduce or substantially eliminate the SARS CoV-2 virus in mammals. In one embodiment, a method of treating a mammal with Covid-19 is provided comprising administering protocatechuic acid to a mammal in need of such treatment a therapeutically effective amount of a protocatechuic acid composition.