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公开(公告)号：WO2009044088A1
公开(公告)日：2009-04-09
申请号：PCT/GB2007/003738
申请日：2007-10-02
Applicant: INVERNESS MEDICAL SWITZERLAND GMBH , DILLEEN, John, William , LOWE, Phillip , POLWART, Ruth , HAY, Jennifer , MARQUORDT, Claus , KEATCH, Steven, Alexander , HOWELL, Steven , THOMPSON, Alan
Inventor： DILLEEN, John, William , LOWE, Phillip , POLWART, Ruth , HAY, Jennifer , MARQUORDT, Claus , KEATCH, Steven, Alexander , HOWELL, Steven , THOMPSON, Alan
IPC: B01L3/00 , G01N33/543
CPC classification number: B01L3/5027 , B01L3/502761 , B01L2200/0647 , B01L2200/14 , B01L2200/148 , B01L2300/0645 , B01L2300/0864 , B01L2300/0887 , B01L2400/043 , B01L2400/0688
Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid:liquid interface to the second liquid. The magnetically susceptible particles are configured to transport an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.
Abstract translation: 测定方法和装置可以在样品液体的单个等分试样上进行至少一个（例如，至少两个）测定。 该装置可以将样品液体与包含磁敏感颗粒的测定试剂混合。 该装置被配置为产生与样品液体的样品液 - 空界面。 当第二液体接触界面以形成液 - 液界面时，磁敏感颗粒可以在液 - 空界面处（通过施加的磁场）定位。 磁性颗粒穿过液体：与第二液体的液体界面。 磁敏感颗粒被配置成将分析物通过界面输送到第二液体中。 在第二液体中进行分析物的测定。 也可以在样品液体中进行另一分析物的测定。
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公开(公告)号：WO2012107717A1
公开(公告)日：2012-08-16
申请号：PCT/GB2012/000122
申请日：2012-02-07
Applicant: MULTI-SENSE TECHNOLOGIES LIMITED , LOWE, Philip , KEATCH, Steven, Alexander , MCGUIGAN, Brian
Inventor： LOWE, Philip , KEATCH, Steven, Alexander , MCGUIGAN, Brian
IPC: G01N33/543
CPC classification number: G01N33/5438 , B01L3/502715 , B01L3/502761 , B01L2200/04 , B01L2200/0647 , B01L2200/16 , B01L2300/0645 , B01L2300/0864 , B01L2300/161 , B01L2400/043 , B01L2400/0688 , C12Q1/001 , C12Q1/006 , C12Y101/03004 , G01N27/3277 , G01N33/54326 , G01N33/54366 , G01N2333/904
Abstract: A subtractive corrective assay device and methodology, whereby ail required binding and label detection reagents are initially located within the detection zone. Application of a magnetic field is used to selectively remove bound label from the detection zone by means of paramagnetic particles. The relationship between measured label concentration before and after the application of a magnetic field within the detection zone is used to accurately measure analyte concentration within the sample.
Abstract translation: 一种减法校正测定装置和方法，其中所需的结合和标记检测试剂最初位于检测区内。 使用磁场来选择性地通过顺磁性粒子从检测区域去除结合的标记物。 检测区内施加磁场之前和之后测量的标记浓度之间的关系用于准确测量样品中的分析物浓度。
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公开(公告)号：WO2007110779A2
公开(公告)日：2007-10-04
申请号：PCT/IB2007/001756
申请日：2007-03-29
Applicant: INVERNESS MEDICAL SWITZERLAND GMBH , LOWE, Phillip , KEATCH, Steven, Alexander , HOWELL, Steven , MARQUORDT, Claus , POLWART, Ruth , THOMSON, Alan, Kenneth
Inventor： LOWE, Phillip , KEATCH, Steven, Alexander , HOWELL, Steven , MARQUORDT, Claus , POLWART, Ruth , THOMSON, Alan, Kenneth
CPC classification number: G01N33/558 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L3/502769 , B01L9/527 , B01L2200/0621 , B01L2200/0668 , B01L2300/0636 , B01L2300/0645 , B01L2300/0672 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0406 , B01L2400/0683 , B01L2400/0688 , B01L2400/086 , G01N33/54326 , G01N33/54366 , G01N35/0098
Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid-liquid interface to the second liquid. The magnetically susceptible particles are configured to transport an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.
Abstract translation: 测定方法和装置可以在样品液体的单个等分试样上进行至少一个（例如，至少两个）测定。 该装置可以将样品液体与包含磁敏感颗粒的测定试剂混合。 该装置被配置为产生与样品液体的样品液 - 空界面。 当第二液体接触界面以形成液 - 液界面时，磁敏感颗粒可以在液 - 空界面处（通过施加的磁场）定位。 磁性颗粒穿过液体 - 液体界面移动到第二液体。 磁敏感颗粒被配置成将分析物通过界面输送到第二液体中。 在第二液体中进行分析物的测定。 也可以在样品液体中进行另一分析物的测定。
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公开(公告)号：WO2012032294A1
公开(公告)日：2012-03-15
申请号：PCT/GB2011/001315
申请日：2011-09-07
Applicant: MULTI-SENSE TECHNOLOGIES LIMITED , LOWE, Phillip , KEATCH, Steven Alexander , MCGUIGAN, Brian
Inventor： LOWE, Phillip , KEATCH, Steven Alexander , MCGUIGAN, Brian
CPC classification number: B01L3/502715 , B01L3/527 , B01L7/00 , B01L2200/027 , B01L2200/0668 , B01L2200/0684 , B01L2200/10 , B01L2300/0609 , B01L2300/0645 , B01L2300/0654 , B01L2300/0816 , B01L2400/043 , B01L2400/0487 , B01L2400/0688 , G01N33/54326 , G01N33/54386 , G01N35/0098
Abstract: The present invention relates to a microfluidic based assay system, comprising a disposable assay cartridge and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using the cartridge and device of the invention, as well as kits for conducting assays.
Abstract translation: 本发明涉及基于微流体的测定系统，其包括一次性测定盒和相关读取装置，以及各个组件本身。 本发明还涉及使用本发明的盒和装置进行测定的方法以及用于进行测定的试剂盒。
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公开(公告)号：WO2007110779A8
公开(公告)日：2008-01-31
申请号：PCT/IB2007001756
申请日：2007-03-29
Applicant: INVERNESS MEDICAL SWITZERLAND , LOWE PHILLIP , KEATCH STEVEN ALEXANDER , HOWELL STEVEN , MARQUORDT CLAUS , POLWART RUTH , THOMSON ALAN KENNETH
Inventor： LOWE PHILLIP , KEATCH STEVEN ALEXANDER , HOWELL STEVEN , MARQUORDT CLAUS , POLWART RUTH , THOMSON ALAN KENNETH
CPC classification number: G01N33/558 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L3/502769 , B01L9/527 , B01L2200/0621 , B01L2200/0668 , B01L2300/0636 , B01L2300/0645 , B01L2300/0672 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0406 , B01L2400/0683 , B01L2400/0688 , B01L2400/086 , G01N33/54326 , G01N33/54366 , G01N35/0098
Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid-liquid interface to the second liquid. The magnetically susceptible particles are configured to transport an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.
