公开(公告)号：WO2012027378A3

公开(公告)日：2012-03-01

申请号：PCT/US2011/048822

申请日：2011-08-23

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  BASF SE ,  FAN, Ben ,  KOLTZENBURG, Roland, S. ,  RIEGER, Jens, B. ,  WEITZ, David, A.

Inventor： FAN, Ben ,  KOLTZENBURG, Roland, S. ,  RIEGER, Jens, B. ,  WEITZ, David, A.

IPC: A61K9/14 ,  A61K9/16 ,  A61K31/565 ,  A61K31/58

Abstract: The present invention generally relates to particles for drug delivery and other applications. In one aspect, the present invention relates to a technique for reacting precursor compounds in the presence of a pharmaceutically- active agent to form product (e.g., in the form of particles) in which the agent is substantially contained within the product, and the product is soluble within typical gastric fluid of a mammal. In another aspect, the present invention is generally directed to particles comprising an inorganic pharmaceutically acceptable carrier, such as CaCO 3 , and an agent. In some cases, at least some of the agent contained within the particles is fluidically inaccessible from externally of the particle. For instance, the agent may be present in isolated domains within the particle. In another aspect, the present invention is generally directed to methods of creating particles. For instance, according to one set of embodiments, two fluids containing reactants are mixed where, upon reaction of the reactants, an insoluble product is formed, which precipitates to form particles. In one example, a first fluid containing dissolved carbonate ions and a second fluid containing dissolved calcium ions and a pharmaceutically- active agent are mixed together; upon mixing of the first and second fluids, the calcium ions and the carbonate ions form calcium carbonate, which precipitates to form a co-precipitate with the pharmaceutically- active agent. Yet other aspects of the present invention are directed to particles formed from such reactions, methods of using such reactions, methods of promoting such reactions, kits involving particles, or the like.

公开(公告)号：WO2012027378A2

公开(公告)日：2012-03-01

申请号：PCT/US2011048822

申请日：2011-08-23

Applicant: HARVARD COLLEGE ,  BASF SE ,  FAN BEN ,  KOLTZENBURG ROLAND S ,  RIEGER JENS B ,  WEITZ DAVID A

Inventor： FAN BEN ,  KOLTZENBURG ROLAND S ,  RIEGER JENS B ,  WEITZ DAVID A

IPC: A61K9/14 ,  A61K9/16 ,  A61K31/565 ,  A61K31/58

CPC classification number: A61K9/143 ,  A61K9/1694 ,  A61K31/565 ,  A61K31/58

Abstract: The present invention generally relates to particles for drug delivery and other applications. In one aspect, the present invention relates to a technique for reacting precursor compounds in the presence of a pharmaceutically- active agent to form product (e.g., in the form of particles) in which the agent is substantially contained within the product, and the product is soluble within typical gastric fluid of a mammal. In another aspect, the present invention is generally directed to particles comprising an inorganic pharmaceutically acceptable carrier, such as CaCO3, and an agent. In some cases, at least some of the agent contained within the particles is fluidically inaccessible from externally of the particle. For instance, the agent may be present in isolated domains within the particle. In another aspect, the present invention is generally directed to methods of creating particles. For instance, according to one set of embodiments, two fluids containing reactants are mixed where, upon reaction of the reactants, an insoluble product is formed, which precipitates to form particles. In one example, a first fluid containing dissolved carbonate ions and a second fluid containing dissolved calcium ions and a pharmaceutically- active agent are mixed together; upon mixing of the first and second fluids, the calcium ions and the carbonate ions form calcium carbonate, which precipitates to form a co-precipitate with the pharmaceutically- active agent. Yet other aspects of the present invention are directed to particles formed from such reactions, methods of using such reactions, methods of promoting such reactions, kits involving particles, or the like.

Abstract translation: 本发明总体上涉及用于药物递送和其他应用的颗粒。 在一个方面，本发明涉及一种用于使前体化合物在药物活性剂存在下反应以形成其中药剂基本上包含在产品内的产品（例如，以颗粒形式）的技术，并且产品 可溶于哺乳动物的典型胃液中。 另一方面，本发明一般涉及包含无机药学上可接受的载体如CaCO 3和药剂的颗粒。 在一些情况下，包含在颗粒内的至少一些试剂从颗粒的外部流体不可接近。 例如，该药剂可能存在于颗粒内的分离域中。 另一方面，本发明总体上涉及产生颗粒的方法。 例如，根据一组实施方案，混合含有反应物的两种流体，其中在反应物反应时形成不溶产物，其沉淀形成颗粒。 在一个实例中，将含​​有溶解的碳酸根离子的第一流体和含有溶解的钙离子的第二流体与药物活性剂混合在一起; 在混合第一流体和第二流体时，钙离子和碳酸根离子形成碳酸钙，其沉淀与药物活性剂形成共沉淀物。 本发明的其他方面涉及由这些反应形成的颗粒，使用这些反应的方法，促进这种反应的方法，涉及颗粒的试剂盒等。

公开(公告)号：WO2010104593A3

公开(公告)日：2010-09-16

申请号：PCT/US2010/000748

申请日：2010-03-12

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  BASF SE ,  WEITZ, David, A. ,  KOLTZENBURG, Roland, S. ,  RIEGER, Jens, B. ,  STUDART, Andre, R. ,  WILKING, James, N.

Inventor： WEITZ, David, A. ,  KOLTZENBURG, Roland, S. ,  RIEGER, Jens, B. ,  STUDART, Andre, R. ,  WILKING, James, N.

IPC: B01J2/22 ,  B01J2/08

Abstract: The present invention generally relates to systems and methods for using particle templating, e.g., to produce composites, discrete particles, or the like. In some embodiments, the present invention generally relates to the production of particles using the interstitial spaces between templating elements in a template structure. For example, a plurality of templating elements, which can include colloidal particles, may be arranged to form a template structure. The interstices of the templating elements can provide regions in which a fluid may be introduced. The fluid may be hardened (e.g., solidified) in some cases, e.g., to form a composite comprising the templating elements and the interstitial segments. In certain embodiments, the template structure may then be broken down to release the hardened fluid, e.g., as a plurality of discrete particles.

公开(公告)号：WO2010104593A2

公开(公告)日：2010-09-16

申请号：PCT/US2010000748

申请日：2010-03-12

Applicant: HARVARD COLLEGE ,  BASF SE ,  WEITZ DAVID A ,  KOLTZENBURG ROLAND S ,  RIEGER JENS B ,  STUDART ANDRE R ,  WILKING JAMES N

Inventor： WEITZ DAVID A ,  KOLTZENBURG ROLAND S ,  RIEGER JENS B ,  STUDART ANDRE R ,  WILKING JAMES N

IPC: B01J2/22

CPC classification number: B01J2/22 ,  B01J2/08 ,  Y10T428/249954

Abstract: The present invention generally relates to systems and methods for using particle templating, e.g., to produce composites, discrete particles, or the like. In some embodiments, the present invention generally relates to the production of particles using the interstitial spaces between templating elements in a template structure. For example, a plurality of templating elements, which can include colloidal particles, may be arranged to form a template structure. The interstices of the templating elements can provide regions in which a fluid may be introduced. The fluid may be hardened (e.g., solidified) in some cases, e.g., to form a composite comprising the templating elements and the interstitial segments. In certain embodiments, the template structure may then be broken down to release the hardened fluid, e.g., as a plurality of discrete particles.

Abstract translation: 本发明一般涉及使用颗粒模板法，例如生产复合材料，离散颗粒等的系统和方法。 在一些实施方案中，本发明通常涉及使用模板结构中的模板元件之间的间隙空间来生产颗粒。 例如，可以布置多个可以包括胶体颗粒的模板元件以形成模板结构。 模板元件的间隙可以提供其中可以引入流体的区域。 在一些情况下，流体可以被硬化（例如，固化），例如形成包含模板元件和间隙段的复合材料。 在某些实施例中，然后可以将模板结构分解以释放硬化的流体，例如作为多个离散颗粒。